Systemic inflammatory dynamics during chemoradiotherapy predict response, relapse, metastasis, and survival in esophageal carcinoma

Sherry, Alexander D.; Newman, N.B.; Anderson, J.; Osmundson, Evan C.

doi:10.1002/jso.25793

Cited by 12 publications

(19 citation statements)

References 49 publications

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“…Meanwhile, emerging evidence indicates that host inflammation relates to cancer pathophysiology and progression 10‐13 . Systemic inflammatory markers (SIMs), which derive from the peripheral blood, such as neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), and lymphocyte‐to‐monocyte ratio (LMR), have been extensively investigated for diagnostic and prognostic value in a variety of solid tumors including thyroid carcinoma 14‐23 . Integrated indicators such as neutrophil‐platelet‐lymphocyte ratio (NPLR) and neutrophil‐monocyte‐lymphocyte ratio (NMLR) have been developed.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic and prognostic value of preoperative systemic inflammatory markers in anaplastic thyroid cancer

Zhang

Luo

Wang

et al. 2020

Journal of Surgical Oncology

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Background Easily accessible, generalized, and inexpensive methods are expected to differentiate anaplastic thyroid carcinoma (ATC) from advanced differentiated thyroid cancer (aDTC). We aimed to explore potential diagnostic and prognostic value of systematic inflammatory markers (SIMs) in ATC and aDTC. Methods About 22 ATC, 101 aDTC, and 100 matched early DTC patients were analyzed retrospectively. SIMs included the comprehensive index, neutrophil‐monocyte‐platelet‐to‐lymphocyte ratio (NMPLR) and the previously reported ones. Receiver operating characteristic, Kaplan‐Meier, and COX regression analyses were mainly conducted. Results NMPLR exhibited the highest area under the curve value 0.806 (P < .0001) to diagnose ATC from aDTC. NMPLR was identified as an independent risk factor for overall survival (OS) (hazard ratio [HR]: 47.821, 95% confidence interval [CI], 2.863‐798.765, P = .007) in ATC, as well as for OS (HR: 7.360, 95% CI, 1.620‐33.430, P = .010) and recurrence‐free survival (HR: 4.172, 95% CI, 1.139‐15.286, P = .031) in aDTC. Taken both refractory types (ATC and aDTC) together, NMPLR could independently predict OS (HR: 6.470; 95% CI, 2.134‐19.616; P = .001). Conclusion NMPLR is a generalized index. It showed excellent potential in differential diagnosis and survival prediction in refractory thyroid cancer. However, it needs to be validated in larger cohort and clinical practice.

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Section: Introductionmentioning

confidence: 99%

Diagnostic and prognostic value of preoperative systemic inflammatory markers in anaplastic thyroid cancer

Zhang

Luo

Wang

et al. 2020

Journal of Surgical Oncology

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“…Neutrophil-to-lymphocyte ratio (NLR) is a novel predictive biomarker that was investigated in three recent studies [ 88 , 89 , 90 ]. The studies were unanimous in demonstrating that NLR was correlated with pCR.…”

Section: Discussionmentioning

confidence: 99%

Predicting Response to Neoadjuvant Therapy in Oesophageal Adenocarcinoma

Jiang

Jong

Hillegersberg

et al. 2022

Cancers

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(1) Background: Oesophageal cancers are often late-presenting and have a poor 5-year survival rate. The standard treatment of oesophageal adenocarcinomas involves neoadjuvant chemotherapy with or without radiotherapy followed by surgery. However, less than one third of patients respond to neoadjuvant therapy, thereby unnecessarily exposing patients to toxicity and deconditioning. Hence, there is an urgent need for biomarkers to predict response to neoadjuvant therapy. This review explores the current biomarker landscape. (2) Methods: MEDLINE, EMBASE and ClinicalTrial databases were searched with key words relating to “predictive biomarker”, “neoadjuvant therapy” and “oesophageal adenocarcinoma” and screened as per the inclusion and exclusion criteria. All peer-reviewed full-text articles and conference abstracts were included. (3) Results: The search yielded 548 results of which 71 full-texts, conference abstracts and clinical trials were eligible for review. A total of 242 duplicates were removed, 191 articles were screened out, and 44 articles were excluded. (4) Discussion: Biomarkers were discussed in seven categories including imaging, epigenetic, genetic, protein, immunologic, blood and serum-based with remaining studies grouped in a miscellaneous category. (5) Conclusion: Although promising markers and novel methods have emerged, current biomarkers lack sufficient evidence to support clinical application. Novel approaches have been recommended to assess predictive potential more efficiently.

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“…and lymphopenia. While high counts of activated neutrophils are known to inhibit cytolytic activity of T-cells and natural killer cells (27), systemic lymphopenia may reflect a decreased presence of lymphocytes in the tumor microenvironment representing a reduced specific host immune response to the tumor (28). Tumor infiltrating lymphocytes are part of the specific host immune response contributing to therapy-mediated tumor control in solid tumors, possibly triggered by the recognition of tumor neoantigens unmasked by the effects of radiochemotherapy (29-31).…”

Section: Discussionmentioning

confidence: 99%

Overall Neutrophil-to-Lymphocyte Ratio and SUVmax of Nodal Metastases Predict Outcome in Head and Neck Cancer Before Chemoradiation

et al. 2021

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IntroductionThis study investigates the pretherapeutic neutrophil-to-lymphocyte ratio (NLR) with markers of tumor metabolism in 18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and their potential prognostic value in head and neck cancer patients prior to primary chemoradiation.Materials and MethodsNLR and metabolic markers of primary tumor and nodal metastases including maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were retrospectively assessed in a consecutive cohort of head and neck squamous cell cancer patients undergoing primary chemoradiation. The main outcome measure was survival.ResultsThe study included 90 patients of which 74 had lymph node metastases at diagnosis. Median follow-up time of nodal positive patients (n=74) was 26.5 months (IQR 18–44). The NLR correlated significantly with metabolic markers of the primary tumor (TLG: rs=0.47, P<0.001; MTV: rs=0.40, P<0.001; SUVmax: rs=0.34, P=0.003), but much less with FDG-PET/CT surrogate markers of metabolic activity in nodal metastases (TLG: rs=0.15, P=0.19; MTV: rs=0.25, P=0.034; SUVmax: rs=0.06, P=0.63). For nodal positive cancer patients, multivariate analysis showed that an increased NLR (HR=1.19, 95% CI=1.04-1.37, P=0.012) and SUVmax of lymph node metastasis (HR=1.09; 95% CI=0.99-1.19; P=0.081) are independently predictive of disease-specific survival. High NLR had a negative prognostic value for overall survival (HR=1.16, 95% CI=1.02-1.33, P=0.021).ConclusionNLR correlates positively with metabolic markers of the primary tumor, suggestive of an unspecific inflammatory response in the host as a possible reflection of increased metabolism of the primary tumor. SUVmax of lymph node metastases and the NLR, however, show no correlation and are independently predictive of disease-specific survival. Therefore, their addition could be used to improve survival prediction in nodal positive head and neck cancer patients undergoing primary chemoradiation.

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Systemic inflammatory dynamics during chemoradiotherapy predict response, relapse, metastasis, and survival in esophageal carcinoma

Cited by 12 publications

References 49 publications

Diagnostic and prognostic value of preoperative systemic inflammatory markers in anaplastic thyroid cancer

Diagnostic and prognostic value of preoperative systemic inflammatory markers in anaplastic thyroid cancer

Predicting Response to Neoadjuvant Therapy in Oesophageal Adenocarcinoma

Overall Neutrophil-to-Lymphocyte Ratio and SUVmax of Nodal Metastases Predict Outcome in Head and Neck Cancer Before Chemoradiation

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