Diagnostic and prognostic value of preoperative systemic inflammatory markers in anaplastic thyroid cancer

Zhang, Lingyun; Luo, Han; Wang, Liying; Liu, Yang; Shu, Rui; Wu, Zhujuan; Wei, Tao; Gong, Renmin; Li, Zhihui; Zhu, Junfei

doi:10.1002/jso.26089

Cited by 9 publications

(7 citation statements)

References 42 publications

(55 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In thyroid cancer, NLR and PLR have diagnostic and predictive significance for advanced differentiated thyroid cancer and ATC, while the diagnostic and predictive significance of NMPLR is far superior to that of NLR or PLR. 32 Similarly, in our study, NLR and PLR were significant for the diagnosis and prediction of PTC cases and healthy individuals, and the combination of NLR+PLR was also meaningful, which achieved far superior diagnostic effect than the individual one. Moreover, IL-27 rs17855750 and rs153109 have been proved to be associated with PTC occurrence, which is partially consistent with our results.…”

Section: Discussionsupporting

confidence: 78%

Relationship Between Serum Inflammatory Factor Levels and Differentiated Thyroid Carcinoma

Zhang

Wang

et al. 2021

Technol Cancer Res Treat

View full text Add to dashboard Cite

Background: Some evidence supports that the significance of inflammation is linked to a variety of tumors, including thyroid carcinoma. This work measured the preoperative serum inflammatory factors in thyroid tumors to explore their diagnostic values. Material and Methods: Altogether 487 thyroid tumor patients were recruited, their neutrophil (NE), white blood cell (WBC), monocyte (MO), lymphocyte (LY), platelet (PLT) counts, together with monocyte/lymphocyte ratio (MLR), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), C-reactive protein (CRP), interleukin (IL)-1β, IL-2, IL-27, and tumor necrosis factor-α (TNF-α) levels were compared with controls. Afterward, the receiver operating characteristics (ROC) curve was plotted to further evaluate the values of these inflammatory markers in diagnosis. In addition, multivariable regression analysis was conducted to analyze all these inflammatory factors. Results: Serum PLR, NLR, CRP, and IL-27 levels in thyroid adenoma (TA) and differentiated thyroid carcinoma (DTC) patients were higher than those in controls. Only the areas under the curve (AUC) for CRP and IL-27 were significant in the context of DTC. Besides, the AUC for IL-27 was significant between papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) groups, while that for NLR+PLR was also significant between PTC and healthy control groups. According to multivariable logistic regression analysis, IL-27 and CRP were associated with DTC. Conclusions: Inflammation plays an important role in TA and DTC progression. Preoperative IL-27 and CRP levels help to differentially diagnose DTC. Moreover, IL-27 assists in distinguishing FTC from PTC, and NLR+PLR is important for the differential diagnosis of PTC.

show abstract

Section: Discussionsupporting

confidence: 78%

Relationship Between Serum Inflammatory Factor Levels and Differentiated Thyroid Carcinoma

Zhang

Wang

et al. 2021

Technol Cancer Res Treat

View full text Add to dashboard Cite

show abstract

“…Twenty-year recurrence rate was only 6% in PTMC [26]. Although the prognostic value of systemic inflammatory markers for advanced thyroid cancer has been reported in some studies [6,27], it is difficult to conduct large-scale studies with relevant In fact, studies on the role of systemic inflammatory markers in thyroid cancer inevitably focus on their predictive values for the diagnosis of thyroid cancers. There is still controversy as to whether systemic inflammatory markers can differentiate between thyroid cancer and benign thyroid nodules.…”

Section: Discussionmentioning

confidence: 99%

“…Twenty-year recurrence rate was only 6% in PTMC [ 26 ]. Although the prognostic value of systemic inflammatory markers for advanced thyroid cancer has been reported in some studies [ 6 , 27 ], it is difficult to conduct large-scale studies with relevant clinical implications due to the low incidence of advanced thyroid cancers. It might be more practical to study the association between systemic inflammatory markers and clinicopathological prognosticators of thyroid cancer, rather than the disease-specific events themselves such as death or recurrence.…”

Section: Discussionmentioning

confidence: 99%

The diagnostic predictive value of neutrophil-to-lymphocyte ratio in thyroid cancer adjusted for tumor size

et al. 2021

View full text Add to dashboard Cite

The role of systemic inflammation has not been clearly defined in thyroid cancers. There have been conflicting reports on whether systemic inflammatory markers have predictive value for thyroid cancers. We aimed to evaluate the association between systemic inflammatory markers and clinicopathological factors in thyroid cancers and to assess their predictive value for thyroid cancers in detail. Five hundred thirty-one patients who underwent surgery for thyroid nodules were included. The patient population consisted of 99 individuals (18.6%) with benign thyroid nodules and 432 individuals (81.4%) with thyroid cancers. In 432 patients with thyroid cancers, neutrophil-to-lymphocyte ratio (NLR) was significantly higher in the cases with tumors greater than 2 cm than in those with tumors less than 2 cm. (p = 0.027). NLR and platelet-to-lymphocyte ratio (PLR) were significantly higher in cases with lateral lymph node metastasis (LNM) than in those without LNM (p = 0.007 and 0.090, respectively). The nodule size was significantly higher in benign thyroid nodules than in thyroid cancers (p < 0.001). When the cases were stratified by tumor size, NLR was a significant predictor of thyroid cancers in cases with nodules greater than 2 cm (Exp(B) = 1.85, 95% CI = 1.15–2.97, p = 0.011), but not in those with nodules less than 2 cm. In thyroid cancers, preoperative NLR was associated with pathological prognosticators such as tumor size and lateral lymph node metastasis. When the size difference between thyroid cancers and benign thyroid nodules was adjusted, NLR could be a significant predictor of thyroid cancers.

show abstract

“…Despite significant advances in clinical treatment of THCA in recent years, it remains lacking of the effective treatment options available to THCA patients (15)(16)(17). The difficulties in the treatment of patients with THCA stem from our limited understanding of molecular mechanism of tumor occurrence, and this provides a new research direction recently (18)(19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

The Novel Tumor Suppressor Gene ZNF24 Induces THCA Cells Senescence by Regulating Wnt Signaling Pathway, Resulting in Inhibition of THCA Tumorigenesis and Invasion

et al. 2021

View full text Add to dashboard Cite

ObjectClinically, the effective treatment options available to thyroid cancer (THCA) patients are very limited. Elucidating the features of tumor suppressor genes (TSGs) and the corresponding signal transduction cascade may provide clues for the development of new strategies for targeted therapy of THCA. Therefore, this paper aims to explore the mechanism of ZNF24 underlying promoting THCA cell senescence at molecular level.MethodsWe performed RT-PCR and Western Blotting for evaluating associated RNA and protein expression. CCK8, colony forming, wound healing and Transwell chamber assays were conducted to examine THCA cell proliferation, invasion and migration. β-galactosidase staining assay was performed to detect THCA cells senescence. The size and volume of xenotransplanted tumors in nude mice are calculated to asses ZNF24 effect in vivo.ResultsEctopic expression of ZNF24 significantly inhibited the cell viability, colony forming, migration and invasion abilities of THCA cell lines (K1/GLAG-66i and BCPAPi) (P < 0.05). ZNF24 induced BCPAPi cells senescence through regulating Wnt signaling pathway. ZNF24 inhibited Wnt signaling pathway activition by competitively binding β-catenin from LEF1/TCF1-β-catenin complex. In nude mice, both Ectopic expression of ZNF24 and 2,4-Da (the strong β-catenin/Tcf-4 inhibitor) treatment significantly decreased both the size and weight of xenotransplanted tumors when compared with control mice (P < 0.05).ConclusionResults obtained in vivo and in vitro reveal the role of ZNF24 in significantly suppressing THCA tumorigenesis and invasion by regulating Wnt signaling pathway.

show abstract

Diagnostic and prognostic value of preoperative systemic inflammatory markers in anaplastic thyroid cancer

Cited by 9 publications

References 42 publications

Relationship Between Serum Inflammatory Factor Levels and Differentiated Thyroid Carcinoma

Relationship Between Serum Inflammatory Factor Levels and Differentiated Thyroid Carcinoma

The diagnostic predictive value of neutrophil-to-lymphocyte ratio in thyroid cancer adjusted for tumor size

The Novel Tumor Suppressor Gene ZNF24 Induces THCA Cells Senescence by Regulating Wnt Signaling Pathway, Resulting in Inhibition of THCA Tumorigenesis and Invasion

Contact Info

Product

Resources

About