Systemic inflammation score is a prognostic marker after curative resection in gastric cancer

Ma, Mingzhe; Weng, Mingzhe; Chen, Fei; Hu, Yiren; Lai, Jianguo; Wang, Yanong; Zhou, Ye

doi:10.1111/ans.15103

Cited by 19 publications

(20 citation statements)

References 31 publications

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“…NPS indicates both inflammatory and nutritional states, along with SIS. Typically, SIS, which is based on the preoperative serum Alb concentration and LMR, is considered as a novel prognostic indicator for GC and ESCC (37,38). The results of our study suggested that SIS was related to the prognosis for AEJ patients; But when we use the SIS to predict RFS, the HR of SIS=1 is similar to the HR of SIS=2, and there is no dose responsibility.…”

Section: A B Figure 2 | (A)mentioning

confidence: 71%

Prognostic Importance of the Preoperative Naples Prognostic Score for Patients With Adenocarcinoma of the Esophagogastric Junction

et al. 2020

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BackgroundThe naples prognostic score (NPS) is established according to nutritional or inflammatory state, and it is identified as the new prognostic score for a variety of malignant tumors. However, its significance in cases suffering from adenocarcinoma of esophagogastric junction (AEJ) who receive surgery remains unclear so far.MethodsIn this study, patients receiving surgery without preoperative therapy were examined between June 2007 and August 2017 in a retrospective way. Typically, the serum albumin level, total cholesterol level, neutrophil-to-lymphocyte ratio, together with the lymphocyte-to-monocyte ratio, was determined to calculate the NPS. The prognostic impact of NPS was evaluated using survival analyses. Time-dependent receiver operating characteristic curve (t-ROC) analysis was also carried out for comparing prognostic impacts of those scoring systems.ResultsAltogether 231 cases were enrolled in this study. A higher NPS showed positive correlation with perineural invasion. Upon multivariate analysis, NPS was identified to be the independent prognostic factor to predict overall survival (OS) along with relapse-free survival (RFS) (both P< 0.05), and an especially strong correlation was observed at advanced pTNM stages based on NPS system. As for subgroup analyses on adjuvant chemotherapy or surgery only, NPS still independently predicted the OS as well as RFS (both P< 0.05) in both groups. Furthermore, t-ROC analysis showed that NPS was more accurate than the systemic inflammation score in predicting OS and RFS.ConclusionsThe NPS represents the simple and useful rating system, which can independently predict the survival for AEJ cases undergoing surgery.

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Section: A B Figure 2 | (A)mentioning

confidence: 71%

Prognostic Importance of the Preoperative Naples Prognostic Score for Patients With Adenocarcinoma of the Esophagogastric Junction

et al. 2020

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“…The serum albumin level and white blood cell count were obtained before surgery in the previous studies of SIS 7–9. In the present study, the serum albumin level and white blood cell count obtained before adjuvant chemoradiotherapy were used to evaluate the role of SIS for AEs and survival in locally advanced rectal cancer patients treated with TME followed by adjuvant chemoradiotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…In the study including 441 clear-cell renal cell carcinoma patients undergoing nephrectomy, SIS was firstly reported to be associated with tumor behaviors and OS after adjusting for traditional clinicopathological features and other markers of systemic inflammation responses 7. The higher SIS score was also associated with poorer OS and DFS in gastric cancer patients after curative gastrectomy 9. In the study of evaluating the prognostic impact of the SIS in colorectal cancer patients after curative resection, 161 (22.1%) patients with rectal cancer who did not receive neoadjuvant chemoradiotherapy or radiation therapy were included.…”

Section: Discussionmentioning

confidence: 99%

“…As the seventh hallmark of cancer, the role of inflammation in radiotherapy toxicity needs further study 6. The systemic inflammation score (SIS), which is based on lymphocyte-to-monocyte ratio (LMR) and serum albumin level, has been reported to be associated with the prognosis of gastric cancer, renal cell carcinoma and colorectal cancer 7–9. Since colon cancer and rectal cancer differ in their biological behaviors, they should be analyzed separately 10,11.…”

Section: Introductionmentioning

confidence: 99%

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<p>Systemic inflammation score in locally advanced rectal cancer patients following total mesorectal excision</p>

Feng¹,

Liu²,

Zhu³

2019

OTT

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ObjectiveThe objective of the study was to evaluate whether any association exists between systemic inflammation score (SIS) and adverse events (AEs) and survival of locally advanced rectal cancer patients treated with total mesorectal excision (TME) followed by adjuvant chemoradiotherapy.Patients and methodsAll of the 109 rectal cancer patients recruited between May 2008 and June 2015 were treated with TME followed by adjuvant chemoradiotherapy. The prognostic ability of SIS for overall survival (OS) was calculated by the receiver operating characteristic (ROC) curves.ResultsAccording to the classification of the SIS, 22 (20.2%), 59 (54.1%) and 28 (25.7%) patients were classified as a score of 2, 1 and 0, respectively. With an area under the curve (AUC) of 0.616, the SIS score of 1 was defined as the optimal cut-off value. Therefore, we divided the patients into the SIS-low group (SIS score of 1 or 0, n=87) and SIS-high group (SIS score of 2, n=22). Multivariate analysis indicated that SIS was associated with OS (HR 0.390, 95% CI 0.186–0.817, P=0.012). The 5-year OS rate in patients without adjuvant chemotherapy was lower than the patients with adjuvant chemotherapy (53.3% vs 75.8%, P=0.010). Multivariate analysis showed that adjuvant chemotherapy was associated with OS (HR 0.217, 95% CI 0.089–0.529, P=0.001). A marginal statistically significant difference was observed in terms of leukopenia during adjuvant chemoradiotherapy between the SIS-low group and the SIS-high group (P=0.05).ConclusionThese results suggest that SIS might serve as an independent biomarker for predicting AEs and prognosis in locally advanced rectal cancer treated with TME followed by adjuvant chemoradiotherapy. Strengthening treatment may be administered to locally advanced rectal cancer with high SIS score obtained before adjuvant chemoradiotherapy.

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“…In theory, SIS, combining LMR and albumin, could better reflect disease change and predict survival outcome. And this assumption has been reported to predict prognosis in several cancer types, including clear cell renal cell carcinoma, gastric cancer and colorectal cancer (23)(24)(25). There are no previous reports regarding the use of SIS in breast cancer.…”

Section: Introductionmentioning

confidence: 96%

The Prognostic Prediction Value of Systemic Inflammation Score and the Development of a Nomogram for Patients With Surgically Treated Breast Cancer

et al. 2020

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Background: Systemic inflammation score (SIS) has been verified as a novel prognostic indicator in several cancer types. However, its prognostic value in breast cancer remains unknown. Furthermore, a nomogram based on SIS is yet to be constructed for breast cancer. We conducted this study to explore the association between SIS and prognosis of breast cancer, and to construct a good prognostic nomogram model. Methods: A total of 1,180 breast cancer patients who underwent curative surgery between December 2010 and January 2013 were recruited. They were randomly assigned to the training set (n = 944) or the validation set (n = 236). All patient blood samples were collected within 1 week prior to operation. According to previous reports, SIS was calculated for all patients, who were then classified into two groups: high-SIS and low-SIS. The Kaplan-Meier method was employed for survival analyses, and univariate and multivariate analyses (Cox proportional hazards regression model) were used for prognostic assessment. A nomogram was constructed based on the results of multivariate analysis. Calibration curves and concordance index (C-index) were compiled to determine predictive and discriminatory capacity.Results: In the training set, the median follow-up time was 6.07 years. Patients in the high-SIS group had an average OS time of 68.05 months, which is shorter than that of the low-SIS group (72.87 months; P = 0.033). Patients in the high-SIS group had average RFS and DMFS times of 56.04 and 54.46 months, respectively, which are shorter than those of the low-SIS group (60.85 and 59.47 months, respectively; P = 0.247 and P = 0.032). Univariate and multivariate analyses revealed SIS to be an independent prognostic factor for OS and DMFS time. The nomogram for the training set indicated OS and DMFS C-indexes of 0.794 (95% CI, 0.772-0.816) and 0.712 (95% CI, 0.684-0.740), respectively.In the validation set, the OS and DMFS C-indexes were 0.889 (95% CI, 0.845-0.933) and 0.696 (95%. CI, 0.611-0.781), respectively.Conclusions: SIS was confirmed as an independent prognostic predictor among patients with breast cancer who had undergone surgery with curative intent. Higher preoperative SIS may indicate higher risk of metastasis and shorter overall survival time. The prognostic nomogram based on SIS was dependable for breast cancer patients who underwent curative surgery.

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Systemic inflammation score is a prognostic marker after curative resection in gastric cancer

Cited by 19 publications

References 31 publications

Prognostic Importance of the Preoperative Naples Prognostic Score for Patients With Adenocarcinoma of the Esophagogastric Junction

Prognostic Importance of the Preoperative Naples Prognostic Score for Patients With Adenocarcinoma of the Esophagogastric Junction

<p>Systemic inflammation score in locally advanced rectal cancer patients following total mesorectal excision</p>

The Prognostic Prediction Value of Systemic Inflammation Score and the Development of a Nomogram for Patients With Surgically Treated Breast Cancer

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