Systemic inflammation and metabolic syndrome in stable COPD patients

Akpınar, Evrim Eylem; Akpinar, Serdar; Ertek, Sibel; Sayın, Esen; Gülhan, Meral

doi:10.5578/tt.4018

Cited by 49 publications

(66 citation statements)

References 38 publications

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“…The authors found that the frequency of metabolic syndrome was higher in the patient group than in the controls. Components of metabolic syndrome like abdominal obesity, hyperglycemia, and hypertension were significantly more prevalent in the patient group (8). In another study, metabolic syndrome and abdominal obesity were often found in patients with COPD (41).…”

Section: Total Oxidant Statusmentioning

confidence: 99%

“…Akpınar et al studied 91 stable patients with COPD and 42 control subjects (8). The authors found that the frequency of metabolic syndrome was higher in the patient group than in the controls.…”

Section: Total Oxidant Statusmentioning

confidence: 99%

“…Patients with COPD show high prevalences of cardiovascular diseases and metabolic syndrome (7,8). Obesity and COPD are common and disabling chronic health conditions.…”

Section: Introductionmentioning

confidence: 99%

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Association analyses of oxidative stress, aerobic capacity, daily physical activity, and body composition parameters in patients with mild to moderate COPD

Genç¹,

Üçok²,

Şener³

et al. 2014

Turk J Med Sci

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IntroductionChronic obstructive pulmonary disease (COPD), one of the most common chronic diseases, is a major cause of morbidity. Oxidative stress is a situation of imbalance between free radicals and antioxidants in favor of the oxidants (1). Today, habitual smoking is the most significant threat to the world's population (2). The development of COPD is mainly associated with tobacco or biomass smoke-induced oxidative stress. Smokers are exposed to thousands of reactive chemicals and trillions of radicals and particles with every cigarette; thus, the molecular reactive oxygen, activity of radicals, and nitrogen species can, over time, lead to a number of detrimental changes in the lungs (3). Oxidative stress is thought to play a central role in the pathogenesis of COPD.Maximal aerobic capacity (VO 2 max) is considered the gold standard for evaluating cardiorespiratory fitness (physical functional capacity) (4). Daily physical activity is the actual level of physical performance that one adopts in daily living. It is not synonymous with physical functional capacity, which can be defined as the maximal performance potential of an individual (5). Aerobic exercise limitation is a common and disturbing manifestation of COPD and is often caused by multiple interrelated physiologic and anatomic disturbances (6). Nevertheless, a hypothesis was proposed that individuals with higher current aerobic function will have greater antioxidant and metabolic capacities to deal with the stresses associated with life, including environmental stresses such as chronic cigarette smoke exposure (3).Patients with COPD show high prevalences of cardiovascular diseases and metabolic syndrome (7,8). Obesity and COPD are common and disabling chronic health conditions. A relationship between obesity and COPD is increasingly recognized, although the nature of this association remains unknown (9). Uygur et al. also found that body fat percentage and total body fat were negatively correlated at a strong level with aerobic capacity Background/aim: To investigate total oxidant and antioxidant status, maximal aerobic capacity, daily physical activity, pulmonary functions, and body composition changes, as well as the associations among these parameters, in patients with mild to moderate chronic obstructive pulmonary disease (COPD) versus healthy controls. Materials and methods:The study included 30 male patients newly diagnosed with COPD and 30 body mass index-matched, nonsmoker male controls. Maximal aerobic capacity, daily physical activity, total oxidant and antioxidant status, pulmonary function tests, body composition, and anthropometric parameters were measured.Results: Maximal aerobic capacity and total antioxidant values were lower in patients with COPD compared to the controls. The total oxidant value, body fat percentage, and waist/hip ratio were higher in patients with COPD than in the healthy controls. There was a moderately negative correlation between the total oxidant value and the maximal aerobic capacity, while there was a moderatel...

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Section: Total Oxidant Statusmentioning

confidence: 99%

Section: Total Oxidant Statusmentioning

confidence: 99%

See 1 more Smart Citation

Association analyses of oxidative stress, aerobic capacity, daily physical activity, and body composition parameters in patients with mild to moderate COPD

Genç¹,

Üçok²,

Şener³

et al. 2014

Turk J Med Sci

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“…KOAH'taki kardiyovasküler hastalık riskindeki artışının, hastalığın kendisiyle ilişkili sistemik enflamasyonun mu, yoksa ortak etiyolojik faktörlerin (yaş, sigara, cinsiyet, düşük sosyoekonomik düzey, vb.) bir sonucu mu olduğu halen aydınlatılmamış bir konudur (1,4).…”

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“…Ancak bu konuda yeterli veri yoktur. Metabolik sendrom prevalansının KOAH'lı olgularda daha yüksek olduğu bildirilmiştir (4,5). Çalışmamızda değerlendirdiğimiz risk faktörleri, metabolik sendrom komponentleri arasında da yer almaktadır (4).…”

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Cardiovascular Risk Factors in Chronic Obstructive Pulmonary Disease

Güngör¹,

Yalçınsoy²,

Bilgin³

et al. 2013

Solunum

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Metabolic Syndrome as a Factor Affecting Systemic Inflammation in Patients with Chronic Obstructive Pulmonary Disease

Rubinsztajn

Przybyłowski

Maskey-Warzęchowska

et al. 2017

Pulmonary Care and Clinical Medicine

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Chronic obstructive pulmonary disease (COPD) is a systemic disease which may be associated with other comorbidities. The aim of the study was to estimate the incidence of metabolic syndrome (MS) in COPD patients and to assess its impact on systemic inflammation and lung function. MS was diagnosed in accordance with the recommendations of the Polish Forum for the Prevention of Cardiovascular Diseases. The study group consisted of 267 patients with stable COPD in all stages of severity. All patients underwent spirometry with bronchial reversibility testing and 6 min walk test (6MWT). The following blood tests were evaluated: lipid profile, glucose and C-reactive protein as well as serum concentration of IL-6, leptin, adiponectin, and endothelin. MS was diagnosed in 93 patients (35.8%). No differences were observed in the incidence of MS in relation to airflow limitation severity (mild; moderate; severe and very severe: 38.9; 36.3; 35.2 and 25.0%, respectively). FEV (% predicted), FVC (% predicted), 6MWT distance (6MWD), age, and the number of pack-years were similar in patients with and without MS. MS was more frequent in males than females (38.7 vs. 28.4%, p > 0.05). Serum concentrations of IL-6, endothelin, leptin, and CRP were higher in the MS group, contrary to adiponectin concentration which was lower (p < 0.01). MS was more frequent in male COPD patients, but there were no differences in its frequency between patients with different severity of airflow limitation. We conclude that MS, as a comorbidity, occurs in all COPD stages and affects systemic inflammation. MS incidence does not depend on COPD severity.

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Systemic inflammation and metabolic syndrome in stable COPD patients

Cited by 49 publications

References 38 publications

Association analyses of oxidative stress, aerobic capacity, daily physical activity, and body composition parameters in patients with mild to moderate COPD

Association analyses of oxidative stress, aerobic capacity, daily physical activity, and body composition parameters in patients with mild to moderate COPD

Cardiovascular Risk Factors in Chronic Obstructive Pulmonary Disease

Metabolic Syndrome as a Factor Affecting Systemic Inflammation in Patients with Chronic Obstructive Pulmonary Disease

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