Systemic immune-inflammation index predicts mortality in infective endocarditis

Abstract

Objectives The aim of our study was to evaluate the usefulness of systemic immune-inflammation index (SII) at admission in predicting in-hospital mortality in patients with infective endocarditis. Methods 133 definite IE patients (≥18 years) according to modified Duke criteria, treated in our tertiary care hospital between December 2009 and May 2019, were retrospectively analysed. Symptoms, comorbidities, predisposing valvular diseases, prosthetic valve, device, history of injectable drug use, blood culture results, echocardiography findings, and complications were collected. We calculated the SII as follows: SII = platelet count × neutrophil count/lymphocyte count at admission. Results The median age of the patients was 56 (40–66) years. Prosthetic valve disease was the most frequent predisposing valve lesion. Staphylococcus species were the most common microorganisms. The most frequent complication was in-hospital mortality (22%) followed by renal failure. Older population, syncope, increased inflammatory markers, high systolic pulmonary artery pressure (PAPs), heart failure, renal failure, and septic shock were associated with high mortality. However age, syncope, hypocalcemia, not going to surgery, and SII were independent predictors of in-hospital mortality. According to receiver operating characteristic curve analysis, the optimal SII cut-off value for predicting mortality was 2314 (area under the curve 0.641; P = 0.019). Conclusion We demonstrated that high SII levels are independently associated with in-hospital mortality. The SII may be a promising prognostic predictor for patients with infective endocarditis.

Systemic Immune-Inflammation Index Predicted Short-Term Outcomes in Patients Undergoing Isolated Tricuspid Valve Surgery

“…Moreover, Seo et al reported that high SII predicted worse outcomes in chronic heart failure [ 8 ]. Recently, several studies have reported the prognostic value of SII in patients with coronary artery disease and infective endocarditis [ 6 , 16 , 27 ]. A retrospective study of patients undergoing off-pump coronary artery bypass grafting demonstrated that high preoperative SII scores are the only hematologic biomarker of postoperative complications [ 7 ].…”

Association of Systemic Immune-Inflammation Index With Short-Term Mortality of Congestive Heart Failure: A Retrospective Cohort Study

“…Compared with the absolute count of single immune cells, SII has a better representation in reflecting the inflammation status of the body, with better stability. Until now, SII has been confirmed to be closely correlated with the poor prognosis of a variety of cardiovascular diseases, including coronary artery disease ( 9 ), aortic stenosis ( 10 ), infective endocarditis ( 11 ), etc., showing good application prospects, but no studies have shown that SII is correlated with the prognosis of patients with CHF. In view of this, the present study attempted to elucidate the independent association between SII and the occurrence of adverse events such as short-term mortality in critically ill patients with CHF, so as to provide reference for the prevention and treatment of heart failure.…”

Association of Systemic Immune-inflammation Index With Short-Term Mortality of Congestive Heart Failure: A Retrospective Cohort Study

“…Compared with the absolute count of single immune cells, SII has a better representation in reflecting the inflammation status of the body, with better stability. Until now, SII has been confirmed to be closely correlated with the poor prognosis of a variety of cardiovascular diseases, including coronary artery disease (Yang et al, 2020), aortic stenosis (Tosu et al, 2021), infective endocarditis (Agus et al, 2020), etc., showing good application prospects, but no studies have shown that SII is correlated with the prognosis of patients with CHF. In view of this, the present study attempted to elucidate the independent association between SII and the occurrence of adverse events such as short-term mortality in critically ill patients with CHF, so as to provide reference for the prevention and treatment of heart failure.…”