Systemic immune-inflammation index in germ-cell tumours

Chovanec, Michal; Čierna, Zuzana; Miskovska, Viera; Macháleková, Katarína; Kalavska, Katarína; Rejleková, Katarína; Světlovská, Daniela; Macak, Dusan; Špánik, S.; Kajo, Karol; Babál, Pavel; Giorgi, Ugo De; Mego, Michal; Mardiak, Jozef

doi:10.1038/bjc.2017.460

Cited by 72 publications

(74 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Neutrophils might not only help promoting inflammatory biomarkers including vascular endothelial growth factor which accelerate cancer progression and metastasis, but also protect tumor from immune surveillance (Mantovani, Cassatella, Costantini, & Jaillon, 2011 Rodriguez, & Ruiz, 2012;Liao et al, 2015). Previous research has suggested the prognostic value of SII in patients undergoing immunotherapy (Chovanec et al, 2018). Accordingly, the SII might act as a prognostic biomarker during immunotherapy.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of prognostic nutritional index and systemic immune‐inflammation index in patients with osteosarcoma

Huang

Zhang

et al. 2019

Journal Cellular Physiology

View full text Add to dashboard Cite

The aim of this study was to evaluate the relationship between prognostic nutritional index (PNI) and systemic immune‐inflammation index (SII) and clinical features and prognosis of osteosarcoma patients. We retrospectively investigated 126 patients with surgery for osteosarcoma between 2012 and 2018 at our hospital. The preoperative PNI was calculated as albumin level (g/L) + 5 × total lymphocyte count (10 9/L). The SII was defined as platelet × neutrophil/lymphocyte counts. The optimal cut‐off values for PNI and SII were evaluated with receiver operating curve analysis. Clinical features and PNI and SII were tested with the χ 2 test. The effects of PNI and SII on overall survival (OS) was investigated by Kaplan–Meier method and Cox proportional hazards model. A low preoperative PNI was remarkably correlated with tumor size, Enneking stage, pathological fracture, local recurrence, metastasis, and neoadjuvant chemotherapy ( p < 0.05). Whereas, a high SII was significantly associated with tumor size, histological type, Enneking stage, and neoadjuvant chemotherapy ( p < 0.05). There was a significant negative relationship between the PNI and SII ( r = 0.384; p < 0.001). For univariate analyses, the results revealed that tumor size, local recurrence, metastasis, PNI, and SII were predictors of OS ( p < 0.05). In multivariate analyses, local recurrence ( p = 0.010), metastasis ( p < 0.001), PNI ( p < 0.001), and SII ( p = 0.029) as independent prognostic factors were significantly correlated with OS. This study suggested that PNI and SII could be important prognostic parameters for patients with osteosarcoma.

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic value of prognostic nutritional index and systemic immune‐inflammation index in patients with osteosarcoma

Huang

Zhang

et al. 2019

Journal Cellular Physiology

View full text Add to dashboard Cite

show abstract

“…Systemic immune‐inflammation index has been well‐known as an independent predictor of recurrence or metastasis of cancers . It was reported that neutrophils could enhance the invasion, proliferation and metastasis of cancer cells and furthermore, platelets could interact with cancer cells and facilitate cancer cell survival and metastasis .…”

Section: Discussionmentioning

confidence: 99%

“…Systemic immune-inflammation index has been wellknown as an independent predictor of recurrence or metastasis of cancers. [5][6][7][8] It was reported that neutrophils could enhance the invasion, proliferation and metastasis of cancer cells and furthermore, platelets could interact with cancer cells and facilitate cancer cell survival and metastasis. 5 Thus, at the time of diagnosis or just prior to operation, SII may predict the aggressive entity of cancer cells, such as recurrence or metastasis in the future.…”

Section: Discussionmentioning

confidence: 99%

“…1,2,4 Systemic immune-inflammation index (SII), which is positively correlated with neutrophil and platelet counts and inversely correlated with lymphocyte count, was first developed by Hu et al 5 So far, many studies have reported the clinical significance of SII in predicting the outcomes of various malignancies, such as cancer recurrence or metastasis. [6][7][8] Besides malignancies, inflammatory burden was also reported to have capability to increase the number of neutrophil and platelet, and decrease that of lymphocyte. [9][10][11] In addition, high activity of AAV at diagnosis was elucidated to be associated with the poor outcomes.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Systemic immune‐inflammation index could estimate the cross‐sectional high activity and the poor outcomes in immunosuppressive drug‐naïve patients with antineutrophil cytoplasmic antibody‐associated vasculitis

et al. 2019

View full text Add to dashboard Cite

show abstract

“…NLR and SII were both independent predictors in a multivariable model of overall survival (OS) when tested separately against the IGCCCG risk classification. Chovanec et al (2018) performed an interesting analysis, whereby they combined SII and the prognostic significance of PD-L1 expression on tumour infiltrating lymphocytes (TILs). These two measurements reflect different aspects of the immune environment; PD-L1's expression on TILs provides an insight into the tumour microenvironment, and SII indicates a global inflammatory status.…”

mentioning

confidence: 99%