Systemic Immune Inflammation Index as a Reliable Disease Activity Marker in Psoriatic Arthritis

Dinçer, Ayşe Bahar Keleşoğlu; Sezer, Serdar

doi:10.29271/jcpsp.2022.06.773

Cited by 28 publications

(30 citation statements)

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“…Compared with previous studies, our conclusions are more convincing and provide sufficient evidence. The study by Kelesoglu et al [ 19 ] collected 106 psoriatic arthritis (PsA) patients and 103 age and gender-matched healthy individuals, showing that compared with patients in remission or with low disease activity, SII levels were significantly higher in PsA patients with moderate to severe disease ( p <0.001). Similarly, Yorulmaz et al [ 20 ] also demonstrated that SII might serve as an independent prognostic indicator for patients with psoriasis and psoriatic arthritis.…”

Section: Discussionmentioning

confidence: 99%

“…The systemic immune-inflammatory index (SII) may be useful in assessing the severity and progression of psoriasis and psoriatic arthritis (PA). In people with higher SII levels, the immune system is in a constant state of activation, leading to chronic inflammation in the joints and other tissues [ 19 , 20 ]. This inflammation can damage cartilage and bone, causing pain and difficulty moving.…”

Section: Introductionmentioning

confidence: 99%

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The association between systemic immune-inflammation index and rheumatoid arthritis: evidence from NHANES 1999–2018

Liu

Wang

et al. 2023

Arthritis Res Ther

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Purpose We aimed to explore the relationship between the systemic immune-inflammation index (SII) and rheumatoid arthritis (RA) using NHANES from 1999 to 2018. Methods We collected data from the NHANES database from 1999 to 2018. The SII is calculated from the counts of lymphocytes (LC), neutrophils (NC), and platelets (PC). The RA patients were derived from questionnaire data. We used weighted multivariate regression analysis and subgroup analysis to explore the relationship between SII and RA. Furthermore, the restricted cubic splines were used to explore the non-linear relationships. Result Our study included a total of 37,604 patients, of which 2642 (7.03%) had rheumatoid arthritis. After adjusting for all covariates, the multivariate logistic regression analysis showed that high SII (In-transform) levels were associated with an increased likelihood of rheumatoid arthritis (OR=1.167, 95% CI=1.025–1.328, P=0.020). The interaction test revealed no significant effect on this connection. In the restricted cubic spline regression model, the relationship between ln-SII and RA was non-linear. The cutoff value of SII for RA was 578.25. The risk of rheumatoid arthritis increases rapidly when SII exceeds the cutoff value. Conclusion In general, there is a positive correlation between SII and rheumatoid arthritis. Our study shows that SII is a novel, valuable, and convenient inflammatory marker that can be used to predict the risk of rheumatoid arthritis in US adults.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The association between systemic immune-inflammation index and rheumatoid arthritis: evidence from NHANES 1999–2018

Liu

Wang

et al. 2023

Arthritis Res Ther

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“…Blood cell biomarkers of inflammation included NLR, PLR, and SII, and these were calculated using the following equations, as performed previously [ 11 , 29 ]: NLR = neutrophils/lymphocytes, PLR = platelets/lymphocytes, and SII = (platelets × neutrophils)/lymphocytes. …”

Section: Methodsmentioning

confidence: 99%

Blood Cell Biomarkers of Inflammation and Cytokine Levels as Predictors of Response to Biologics in Patients with Psoriasis

Andersen

Kvist-Hansen

Siewertsen

et al. 2023

IJMS

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For people with psoriasis, biomarkers aiding in the personalization of treatment with biologics are needed. We examined the usefulness of several biomarkers of inflammation in this respect. The neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and the systemic immune–inflammation index (SII) were measured in patients with psoriasis initiating TNF-α inhibitors (n = 131), IL-17/IL-17R inhibitors (n = 65), or IL-23/IL-12/23 inhibitors (n = 50). The blood levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, interferon (IFN)-γ, IL-17A, IL-6, soluble IL-6 receptor (sIL-6R), and soluble IL-6 signal transducer (sIL-6ST) were measured in patients initiating adalimumab (n = 62) or IL-17/IL-17R inhibitors (n = 24). Treatment response was defined by a psoriasis area and severity index (PASI) ≤ 2 three months after treatment initiation. Responders to TNF-α inhibitors had a lower NLR at baseline than non-responders (median and interquartile range (IQR) 2.15 (1.67–2.86) vs. 2.54 (1.88–3.55); p = 0.04). Responders to treatment with adalimumab had lower IL-6 levels at baseline than non-responders (0.99 (0.42–1.4) vs. 1.62 (0.96–2.41) pg/mL; p = 0.02). For the majority of patients, the IL-17A, IL-1β, and IFN-γ levels were below quantification limits. NLR and IL-6 may serve as predictive biomarkers of treatment response to TNF-α inhibitor therapy in patients with psoriasis.

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“…As promising systemic inflammation markers, SII, NLR, and PLR have been studied in a variety of chronic diseases. SII is thought to be a predictive and prognostic marker for multiple cancers [ 30 , 38 , 44 , 45 ], autoimmune diseases [ 46 , 47 ], cardiovascular disorders [ 28 , 48 , 49 ], and metabolic diseases [ 50 ]. There is no consensus on the normal value of SII, and in related research, most researchers utilized receiver operating characteristic curve (ROC) analysis to find various cutoff points for specific diseases, most of which are around 600 × 10 9 /L.…”

Section: Discussionmentioning

confidence: 99%

OCT-Based Biomarkers are Associated with Systemic Inflammation in Patients with Treatment-Naïve Diabetic Macular Edema

et al. 2022

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This cross-sectional study aimed to comprehensively investigate the association between optical coherence tomography (OCT) biomarkers and systemic inflammation in patients with diabetic macular edema (DME), which is short of research and well worth attention.This study found that hyperreflective foci (HRF) are positively associated with systemic immune-inflammatory index (SII) in multivariable regression models, while other OCT biomarkers are not significantly related to systemic inflammation in the current study.Systemic inflammatory markers might be helpful for DME classification and treatment decision.

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Systemic Immune Inflammation Index as a Reliable Disease Activity Marker in Psoriatic Arthritis

Cited by 28 publications

References 0 publications

The association between systemic immune-inflammation index and rheumatoid arthritis: evidence from NHANES 1999–2018

The association between systemic immune-inflammation index and rheumatoid arthritis: evidence from NHANES 1999–2018

Blood Cell Biomarkers of Inflammation and Cytokine Levels as Predictors of Response to Biologics in Patients with Psoriasis

OCT-Based Biomarkers are Associated with Systemic Inflammation in Patients with Treatment-Naïve Diabetic Macular Edema

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