The association between systemic immune-inflammation index and rheumatoid arthritis: evidence from NHANES 1999–2018

Abstract

Purpose We aimed to explore the relationship between the systemic immune-inflammation index (SII) and rheumatoid arthritis (RA) using NHANES from 1999 to 2018. Methods We collected data from the NHANES database from 1999 to 2018. The SII is calculated from the counts of lymphocytes (LC), neutrophils (NC), and platelets (PC). The RA patients were derived from questionnaire data. We used weighted multivariate regression analysis and subgroup analysis to explore the relationship between SII and RA. Furthermore, the restricted cubic splines were used to explore the non-linear relationships. Result Our study included a total of 37,604 patients, of which 2642 (7.03%) had rheumatoid arthritis. After adjusting for all covariates, the multivariate logistic regression analysis showed that high SII (In-transform) levels were associated with an increased likelihood of rheumatoid arthritis (OR=1.167, 95% CI=1.025–1.328, P=0.020). The interaction test revealed no significant effect on this connection. In the restricted cubic spline regression model, the relationship between ln-SII and RA was non-linear. The cutoff value of SII for RA was 578.25. The risk of rheumatoid arthritis increases rapidly when SII exceeds the cutoff value. Conclusion In general, there is a positive correlation between SII and rheumatoid arthritis. Our study shows that SII is a novel, valuable, and convenient inflammatory marker that can be used to predict the risk of rheumatoid arthritis in US adults.

Association of systemic inflammation index with psoriasis risk and psoriasis severity: A retrospective cohort study of NHANES 2009 to 2014

“…Besides, significant differences in race, monocyte, and WBC were observed in 2 psoriasis groups as well as 4 SII groups. Liu et al [22] revealed that SII was positively related to rheumatoid arthritis risk. Additionally, SII served as a reliable inflammatory marker for predicting the osteoporosis risk or low bone mineral density among postmenopausal women.…”

Association between preoperative systemic immune inflammation index and postoperative sepsis in patients with intestinal obstruction: A retrospective observational cohort study

“…34 Other studies also reported the potential role of SII in cardiocerebral vascular disease. [35][36][37] A higher SII has also been associated with an increased risk of POCD, 38 rheumatoid arthritis, 39 and postoperative pulmonary complications. 40 The PLT, neutrophil, and LYMPHs could all be examined routinely and easily in patients undergoing selective and emergency procedures, making the marker available to doctors in our daily practice.…”

Association between probiotic consumption and periodontitis: Evidence from NHANES 2009–2014

“…Participants were classified based on their BMI as underweight and normal weight (BMI < 25 kg/m 2 ), overweight (BMI = 25-30 kg/m 2 ) and obese (BMI > 30.0 kg/m 2 ) (Hastie et al, 2010). PIR was divided into three levels, PIR < 1.3 as low household income, PIR 1.3-3.5 as medium household income and PIR > 3.5 as high household income (Liu et al, 2023). Similarly, education levels were divided into three categories: less than high school level, high school level and more than high school level.…”