Systemic hormonal and physiological abnormalities in anxiety disorders

Cameron, Oliver G.; Nesse, Randolph M.

doi:10.1016/0306-4530(88)90054-6

Cited by 76 publications

(35 citation statements)

References 197 publications

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“…Low levels of melatonin have also been reported in premenstrual dysphoric disorder [10] and panic disorder [11]. Conflicting results of melatonin levels were reported in eating disorders [12][13][14] as well as in schizophrenia [15,16].…”

Section: Melatonin and Psychiatric Disordersmentioning

confidence: 83%

Melatonin in Psychiatric Disorders – Subtyping Affective Disorder

Wahlund

1999

Neurosignals

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Altered diurnal secretory patterns, i.e. altered phase and/or amplitude of melatonin have been reported in sleep and affective disorders. The alteration may depend on environmental factors which in vulnerable individuals may cause sleep and/or affective disorders. Early stress in conjunction with development of resistance to corticotropin-releasing hormone may be linked to the low melatonin syndrome in subgroups of depressed patients. Also the seasonal variation in melatonin as well as serotonin may be linked to the seasonal pattern seen in subgroups of affective disorders. Melatonin may be used as a combined marker for proneness to develop affective disorders especially in latent carriers of bipolar disorders.

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Section: Melatonin and Psychiatric Disordersmentioning

confidence: 83%

Melatonin in Psychiatric Disorders – Subtyping Affective Disorder

Wahlund

1999

Neurosignals

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“…Recently, we have reported significant elevations of saliva cortisol levels during spontaneously occurring panic attacks (Bandelow et al 2000a). Other authors, however, found normal baseline plasma levels in panic patients (Brambilla et al 1992;Cameron et al 1987;Cameron and Nesse 1988;Liebowitz et al 1985;Villacres et al 1987;Woods et al 1988). One possible explanation for these discrepant findings could be related to the observation from the present study showing that temporary withdrawal from smoking leads to a reduction of baseline cortisol levels, thus masking an overactive HPA axis in PD patients.…”

Section: The Hypothalamic-pituitary-adrenal System In Pdmentioning

confidence: 95%

Smoking Modulates Neuroendocrine Responses to Ipsapirone in Patients with Panic Disorder

Broocks

Bandelow

Koch

et al. 2002

Neuropsychopharmacology

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Reduced 5-HT1A-receptor responsiveness has been reported in patients with panic disorder(PD) and/or agoraphobia (PDA). Although many of these patients are regular smokers, it has not been examined whether psychological or neurobiological effects induced by the selective 5-HT1A-receptor agonist, ipsapirone, are affected by the smoking status of the patients.In order to clarify this question neuroendocrine challenges with oral doses of ipsapirone (0.3 mg/kg) Neuropharmacological challenges with the selective 5-hydroxytryptamine-1A (5-HT1A) receptor agonist, ipsapirone, have been used in several studies to assess 5-HT1A-receptor related functions in patients suffering from various neuropsychiatric disorders (Broocks et al. 2000;Lesch et al. 1990a;Lesch et al. 1991;Lesch et al. 1990b;Lesch et al. 1992) and in healthy controls (Broocks et al. 1999;Kahn et al. 1994;Lesch et al. 1990c;Lesch et al. 1990d).Indices of abnormal serotonergic function have been reported in patients with panic disorder (PD) and/or agoraphobia (PDA). In particular, there is evidence for an increased sensitivity of the 5-HT 2C subsystem (Charney et al. 1987a;Charney et al. 1987b;Kahn et al. 1988a Kahn and Wetzler 1991;Kahn et al. 1988b). In contrast, stimulation of 5-HT 1A receptors by ipsapirone was followed by an attenuated hypothermic and ACTH/cortisol response in patients with PDA (Broocks et al. 2000;Lesch et al. 1992). In healthy controls, ipsapirone produces dose-dependent increases in plasma cortisol and ACTH as well as dose-dependent reductions in body temperature (Cowen 2001;Kahn et al. 1994;Lesch et al. 1989). Ipsapirone acts on specific serotonergic mechanisms in the brain through its high-affinity binding to the 5-HT 1A receptor subtype. The binding sites are predominantly located on serotonergic neurons in the raphe nuclei (presynaptic autoreceptors) and in limbic structures (postsynaptic receptors). Agonistic properties at presynaptic somatodendritic sites have been observed, resulting in decreased serotonergic neurotransmission (Peroutka 1985). Concerning the high selectivity of ipsapirone, it has to be considered that the metabolite 1-(2-pyrimidinyl)-piperazine (1-PP) has been found to exert antagonistic effects at pre-and postsynaptic ␣ 2-adrenoceptors (Blier et al. 1991;Miller et al. 1992).Several lines of evidence suggest that serotonergic neurotransmission, including the regulation of 5-HT1A receptors, is affected by nicotine (Benwell et al. 1990;Kenny et al. 2001). Recent studies show that some of nicotine's psychotropic and endocrine effects are exerted by stimulation of 5-HT1A receptors on dorsal raphe neurons (Cheeta et al. 2001;Mihailescu et al. 2001).There is a high incidence of smoking in patients with anxiety and other psychiatric disorders (Breslau et al. 1993;Glassman 1993;Kendler et al. 1993;Marks et al. 1997;Miller and Gold 1998;Sellman et al. 1999). To our knowledge, no clinical studies have examined the question of whether psychological or neurobiological effects induced by serotonergic agents such as ipsapi...

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“…Cameron ve arkadaşlarının panik bozukluğu ile ilgili yaptıkları bir çalışmada, panik bozukluğunda azalmış gece melatonin düzeyi saptanmış-tır. [124] Tüm bu veriler, melatonin hormonunun psikiyatri ile ilgili birçok hastalıkla ilişkili olduğunu ortaya koymaktadır. Günümüze kadar yapılan bu çalış-malar, melatoninin gelecekte de psikiyatri ile ilişkili hastalıkların incelenmesinde önemli bir yer tutacağını göstermektedir.…”

Section: Melatonin Ve Psikiyatrik Hastalıklarunclassified

An Overview On Melatonin Hormone

Özçeli̇k¹,

Erdem²,

Bolu³

et al. 2013

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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ÖZETMelatonin hormonu, son yıllarda tüm dünyada gittikçe artan bir ilgiyle araştı-rılmaktadır. Ana görevi vücudun biyolojik saatini koruyup ritmini ayarlamak olan melatonin, vücudun birçok biyolojik ve fizyolojik süreçlerinde yer alır. Hücrelerin yenilenmesi, bağışıklık siteminin güçlenmesi, uyku ritminin ve vücut ısısının düzenlenmesi diğer önemli görevleri arasındadır. Lipofilik özel-liği nedeniyle bilinen en güçlü antioksidandır. Bu özelliği sayesinde tüm vücut alanlarına ulaşabilmekte ve kan-beyin bariyerini geçebilmektedir. Uyku problemi olan kişilerde melatoninin düşük düzeyde bulunması, ilaç olarak kullanımını akla getirmektedir. Yapılan uygulamaların ardından melatoninin uyku total süresini değiştirmeden uyku kalitesini artırdığı belirlenmiştir. Ancak yaygın araştırılmasına rağmen melatoninin işlevleri halen tamamıyla bilinmemektedir. Bu nedenle melatonin ile ilgili mevcut bilgilerin gözden geçirilmesi, bu alanda araştırma yapanlara rehberlik edecektir. Anahtar Sözcükler: Melatonin, uyku, biyolojik saat, antioksidan. ABSTRACTIn recent years, there is a growing interest in melatonin all over the world. The main task of protecting the body's biological clock, which set the rhythm of melatonin, involves many biological and physiological processes of the body. Cell renewal, strengthening of the immune system and body temperature regulation are other tasks of melatonin. Melatonin, with its lipophilic property, is the most powerful antioxidant as it can reach all body areas and can easily pass the blood-brain barrier. The fact that individuals with low levels of melatonin have sleep problems lead to the consideration of melatonin as a therapeutic medicine in this field. The detailed researches have shown that melatonin can improve sleep quality without changing the total duration of sleep. Nevertheless, despite high number of researches done, the functions ©2013, Psikiyatride Güncel Yaklaşımlar eISSN:1309-0674 pISSN:1309-0658

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Systemic hormonal and physiological abnormalities in anxiety disorders

Cited by 76 publications

References 197 publications

Melatonin in Psychiatric Disorders – Subtyping Affective Disorder

Melatonin in Psychiatric Disorders – Subtyping Affective Disorder

Smoking Modulates Neuroendocrine Responses to Ipsapirone in Patients with Panic Disorder

An Overview On Melatonin Hormone

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