Systemic exposure and urinary excretion of vanadium following perinatal subchronic exposure to vanadyl sulfate and sodium metavanadate via drinking water

Waidyanatha, Suramya; Weber, Frank; Fallacara, Dawn M.; Harrington, James M.; Levine, Keith; Robinson, Victor A.; Sparrow, Barney; Stout, Matthew D.; Fernando, Reshan; Hooth, Michelle J.; Xie, Guanhua; Roberts, Georgia

doi:10.1016/j.toxlet.2022.03.004

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…Since food and water are the most likely routes of exposure for humans, NaVO 3 was administered to the mice in drinking water ad libitum for 28 days (days 0 to 27). The drinking water concentrations were 0, 31.3, 62.5, 125, 250, and 500 ppm NaVO 3 , based on previously published work (Roberts et al, 2016;Waidyanatha et al, 2022), and confirmed by HPLC with ultraviolet detection at 282 nm. Palatability issues were observed in a previous DTT 14-day study in B6C3F1/N mice at 500, 1,000, and 2,000 ppm NaVO 3 , with overt toxicity at 1,000 and 2,000 ppm (Roberts et al, 2016).…”

Section: Chemicalssupporting

confidence: 69%

Evaluation of immunotoxicity of sodium metavanadate following drinking water exposure in female B6C3F1/N mice in a 28‐day study

Frawley

Johnson²,

Burleson³

et al. 2023

J of Applied Toxicology

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Sodium metavanadate (NaVO3) is a pentavalent vanadium compound used in the metal industry and dietary supplements; human exposure occurs through inhalation of fumes and dust and ingestion of NaVO3‐containing products. The objective of this study was to assess the potential immunotoxicity of NaVO3. Female B6C3F1/N mice were exposed to 0–500 ppm NaVO3 in drinking water for 28 days and evaluated for effects on immune cell populations and innate, cellular‐mediated, and humoral‐mediated immunity. There was a decreasing trend in body weight (BW) and BW gain in NaVO3 exposed mice, with a decrease (p ≤ 0.05) in BW gain at ≥250 ppm, relative to control. Conversely, increasing trends in spleen weights and an increase (p ≤ 0.05) in the spleen:BW ratio at ≥250 ppm NaVO3 were observed. NaVO3 exposure altered antibody production against sheep red blood cells (SRBC). Antibody forming cells (AFC)/106 spleen cells exhibited a decreasing trend, with a decrease (p ≤ 0.05) at 500 ppm NaVO3, concurrent with an increase in percent B cells. NaVO3 had no effect on the serum anti‐SRBC IgM antibody titers or anti‐keyhole limpet hemocyanin antibody production. Exposure to NaVO3 decreased the percentage of natural killer cells at all dose levels (p ≤ 0.05), with no effect on the lytic activity. NaVO3 altered T‐cell populations at 500 ppm but had no effect on T‐cell proliferative responses or the lytic activity of cytotoxic T cells. Collectively, these data indicate that NaVO3 exposure can adversely affect the immune system by inducing alterations in humoral‐mediated immunity, specifically the AFC response, with no effect on cell‐mediated or innate immunity.

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Section: Chemicalssupporting

confidence: 69%

Evaluation of immunotoxicity of sodium metavanadate following drinking water exposure in female B6C3F1/N mice in a 28‐day study

Frawley

Johnson²,

Burleson³

et al. 2023

J of Applied Toxicology

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“…This may be in part due to absorption, distribution, metabolism, and excretion differences between V 4+ and V 5+ compounds, wherein, at the end of these 3-month studies, up to threefold higher concentrations of vanadium in plasma and urine (measured in rats only) were observed in rats exposed to sodium metavanadate compared to rats exposed to vanadyl sulfate, when normalizing for vanadium intake per day (i.e., mg vanadium/day). 40 This pattern of higher concentrations of vanadium in plasma and urine from V 5+ exposure compared to V 4+ was also seen in shorter-term studies conducted as part of a National Toxicology Program (NTP) research program. 73 In mice, total vanadium intake did not seem to dictate the level at which an effect occurred.…”

Section: Discussionmentioning

confidence: 73%

NTP Technical Report on the Toxicity Studies of Sodium Metavanadate (CASRN 13718-26-8) and Vanadyl Sulfate (CASRN 27774-13-6) Administered in Drinking Water to Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats and B6C3F1/N Mice

2023

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Oral human exposure to vanadium may occur due to its presence in food and drinking water and its use in dietary supplements. The most prevalent oxidation states of vanadium in food and drinking water have been characterized as tetravalent and pentavalent. Vanadyl sulfate and sodium metavanadate were selected as representative tetravalent (V 4+ ) and pentavalent (V 5+ ) test articles for these studies, respectively. To assess the potential for oral toxicity of vanadium compounds with differing oxidation states under similar test conditions, the 3-month National Toxicology Program (NTP) toxicity studies of sodium metavanadate and vanadyl sulfate in male and female Sprague Dawley (Hsd:Sprague Dawley ® SD ® ) rats (including perinatal exposure) and in B6C3F1/N mice. Drinking water concentrations for sodium metavanadate (0, 31.3, 62.5, 125, 250, and 500 mg/L) and vanadyl sulfate (0, 21.0, 41.9, 83.8, 168, and 335 mg/L) were selected on the basis of previously published 14-day drinking water studies conducted as part of the NTP vanadium research program.

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A study on the preparation of V2O5 from NH4V3O8 based on thermal decomposition including the thermal decomposition temperature effect, mechanism and kinetics

Ying,

Zhao,

et al. 2023

Chemical Engineering Research and Design

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Systemic exposure and urinary excretion of vanadium following perinatal subchronic exposure to vanadyl sulfate and sodium metavanadate via drinking water

Cited by 4 publications

References 23 publications

Evaluation of immunotoxicity of sodium metavanadate following drinking water exposure in female B6C3F1/N mice in a 28‐day study

Evaluation of immunotoxicity of sodium metavanadate following drinking water exposure in female B6C3F1/N mice in a 28‐day study

NTP Technical Report on the Toxicity Studies of Sodium Metavanadate (CASRN 13718-26-8) and Vanadyl Sulfate (CASRN 27774-13-6) Administered in Drinking Water to Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats and B6C3F1/N Mice

A study on the preparation of V2O5 from NH4V3O8 based on thermal decomposition including the thermal decomposition temperature effect, mechanism and kinetics

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