Systemic effects of hypernephroma

Cherukuri, Sundar V.; Johenning, Paul W.; Ram, M D

doi:10.1016/0090-4295(77)90001-2

Cited by 18 publications

(10 citation statements)

References 27 publications

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“…A diagnosis of RCC early enough for potentially curative surgery remains a great challenge to the clinician because small, still localized, tumours are often symptom-free and more advanced tumours may have a multifaceted presentation [3,4,[10][11][12][13][14]. RCC can be classed among the great mimics in clinical medicine [11].…”

Section: Discussionmentioning

confidence: 99%

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Rising erythrocyte sedimentation rate during several years before diagnosis can be a predictive factor in 70% of renal cell carcinoma patients. The benefit of knowing subject‐based reference values

Iversen¹,

Roger²,

Solberg³

et al. 1996

Journal of Internal Medicine

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Systematic ESR graphic recordings over time will enable a physician to determine each individual's baseline value, and hence note any continuously rising trend, which should lead to further investigations, e.g. an ultrasound kidney examination. This may provide an early clue to many otherwise non-symptomatic RCC cases. It is time for a reappraisal of the predictive value of the ESR to discover early RCC, and possibly other diseases as well.

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Section: Discussionmentioning

confidence: 99%

“…Early latent RCC is generally symptom-free and the first indications may be diffuse and non-urologic [2][3][4]. The classical presenting symptoms and signs, including a palpable abdominal mass, are found only in advanced cases.…”

Section: Introductionmentioning

confidence: 99%

Rising erythrocyte sedimentation rate during several years before diagnosis can be a predictive factor in 70% of renal cell carcinoma patients. The benefit of knowing subject‐based reference values

Iversen¹,

Roger²,

Solberg³

et al. 1996

Journal of Internal Medicine

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“…This is due to altered production of various hormones produced by the kidney, including erythropoietin 24. Normocytic and microcytic anaemia have been reported in up to 88% of patients with advanced disease 24 25. Weight loss and fever are also common symptoms.…”

Section: Discussionmentioning

confidence: 99%

Transient ischaemic attack secondary to paraneoplastic erythrocytosis

Sandoval¹,

Robles

Andrus³

et al. 2014

BMJ Case Reports

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A 67-year-old woman with a history of hypertension and type 2 diabetes mellitus was admitted to the hospital due to aphasia and left-sided hemiparesis during the past 5 h with resolution of symptoms within 24 h. On admission laboratory analysis showed haemoglobin 19.2 g/dL and haematocrit 55.1%. Cerebral CT scan was also performed on admission revealing periventricular leucoaraiosis. Studies to investigate the cause of erythrocytosis were started and elevated erythropoietin levels were found. In order to investigate a secondary cause of erythrocytosis an abdominal ultrasound was conducted revealing a left renal mass. CT scans of thorax, abdomen and pelvis confirmed renal mass 8 × 8 cm of diameter, suggestive of neoplasm without associated lymphadenopathy or metastases. Radical nephrectomy was performed and a pathological diagnosis demonstrated clear cell renal cell carcinoma and was staged as T2aN0M0.

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“…One patient had a co-incidental sigmoid colon polyp with a weakly positive faecal occult blood test, but no other patient had a documented source of genito-urinary or gastro-intestinal blood loss. The reported incidence of anaemia in renal cell carcinoma ranges from 24 to 64% [10][11][12], but generally is associated with a normochromic, normocytic blood film [4,13]. In up to one-third of cases the anaemia may be hypochromic and microcytic and not explained by haematuria or other causes of blood loss [11,14].…”

Section: Discussionmentioning

confidence: 99%

The presentation, treatment and outcome of renal cell carcinoma in old age

Doherty

Rüfer²,

Bartholomew³

et al. 1999

Age and Ageing

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Objective: to review clinical presentation and outcome of patients with a diagnosis of renal cell carcinoma at a district general hospital and assess whether older patients were more likely to present in a non-specific manner or receive more conservative management and whether their survival was less favourable. Subjects and methods: 39 patients presenting with a diagnosis of renal cell carcinoma between 1987 and 1995 were identified from hospital activity analysis data and histopathology records. We divided the subjects into young patients (< 69 years: n = 27) and elderly patients (>70 years: n = 10), and made a retrospective analysis of clinical features, laboratory results, pathology, staging, treatment and survival from hospital records. Results: anaemia, hypertension and weight loss were common clinical features in both young and elderly groups. The prevalence of non-urological symptoms did not differ between study groups. Anaemia was frequently microcytic and hypochromic. Hypertension was present in 46% of patients and one-third of these were newly diagnosed. In 19% of patients with renal cell carcinoma, the diagnosis was made incidentally while imaging for other indications. Elderly patients were as likely to receive surgical treatment as younger patients. Survival differed with stage but not age. Conclusions: neither clinical presentation, management nor survival differed between the young and elderly subjects. Renal cell carcinoma should be considered in elderly patients with systemic features such as malaise or weight loss associated with anaemia, hypertension and raised erythrocyte sedimentation rate.

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Systemic effects of hypernephroma

Cited by 18 publications

References 27 publications

Rising erythrocyte sedimentation rate during several years before diagnosis can be a predictive factor in 70% of renal cell carcinoma patients. The benefit of knowing subject‐based reference values

Rising erythrocyte sedimentation rate during several years before diagnosis can be a predictive factor in 70% of renal cell carcinoma patients. The benefit of knowing subject‐based reference values

Transient ischaemic attack secondary to paraneoplastic erythrocytosis

The presentation, treatment and outcome of renal cell carcinoma in old age

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