Rising erythrocyte sedimentation rate during several years before diagnosis can be a predictive factor in 70% of renal cell carcinoma patients. The benefit of knowing subject‐based reference values

Abstract

Systematic ESR graphic recordings over time will enable a physician to determine each individual's baseline value, and hence note any continuously rising trend, which should lead to further investigations, e.g. an ultrasound kidney examination. This may provide an early clue to many otherwise non-symptomatic RCC cases. It is time for a reappraisal of the predictive value of the ESR to discover early RCC, and possibly other diseases as well.

Raised inflammatory markers

“…[21][22][23] However, has been shown to have no discriminatory value in diagnosing these conditions, even in secondary care, where there is a higher prevalence than in primary care. 24 In summary, there are a few clinical situations in which testing of inflammatory markers is the optimum test, as either a "rule in" or a "rule out" test.…”

Population‐based erythrocyte sedimentation rates in 3910 subjectively healthy Norwegian adults. A statistical study based on men and women from the Oslo area

“…The current material was primarily collected to serve as a sex-and age-specific control for another study of the ESR, dealing with the value of a progressive and significant ESR increment over several years as a predictive factor for the diagnosis of renal carcinoma in a series of 236 Norwegian patients [1]. Our results are also of general interest, however, since they can be used to estimate the 95 % upper population-based ESR reference boundaries for single recordings in lines) were significantly higher in women up to the age of 75 years, after which the estimated sexspecific 95 % confidence limits for mean values were found to overlap.…”

Changes in symptoms of renal cell carcinoma over four decades

“…Hypercalcaemia is caused mostly by parathyroid hormone‐related protein secreted from a primary tumour, more rarely by local osteolytic metastases or prostaglandin‐mediated factors [21]. Also, an elevated ESR was noted in 26% of the present patients, but if systematically recorded can be found in 70% of patients with RCC [23]. The ESR has been shown to increase significantly for up to ≥6 years before the diagnosis, and the increase is marked during the last year before the malignancy becomes apparent.…”

“…The ESR has been shown to increase significantly for up to ≥ 6 years before the diagnosis, and the increase is marked during the last year before the malignancy becomes apparent. The mean ESR is 47 mm/h in men and 52 mm/h in women, but 20% of the patients in the cited study had an ESR of > 100 mm/h [23]. Varicocele is often a late sign of RCC, carrying a very poor prognosis.…”