Systemic Diseases Caused by Oral Infection

Li, Xiaojing; Kolltveit, Kristin M.; Tronstad, Leif; Olsen, Ingar

doi:10.1128/cmr.13.4.547-558.2000

Cited by 649 publications

(430 citation statements)

References 130 publications

(117 reference statements)

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“…Studies have suggested that periodontal infections and oral bacteria may be risk factors for a number of prevalent systemic diseases (20,31). Likewise, pathogens that cause these medically important diseases may harbor the oral cavity.…”

Section: Resultsmentioning

confidence: 99%

“…Epidemiological studies have suggested that oral infection, specially periodontitis, may be a risk factor for systemic diseases, including respiratory diseases, cardiovascular diseases, and stroke (1,20,31,32). Periodontal diseases are bacterial infections associated with a complex microbiota of the dental biofilm, composed predominantly by strictly anaerobic Gram -negative species.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of "non-oral" pathogenic bacteria in subgingival biofilm of subjects with chronic periodontitis

Souto¹,

Andrade²,

Uzeda³

et al. 2006

Braz. J. Microbiol.

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The oral cavity may act as a reservoir for several pathogens related to systemic infections. Therefore, the purpose of this study was to determine the prevalence and levels of pathogenic bacteria in the subgingival biofilm of chronic periodontitis lesions and healthy periodontal sites using the checkerboard DNA-DNA hybridization technique. 200 samples of subgingival biofilm from sites with periodontitis (probing pocket depth ≥ 4 mm and /or clinical attachment level ≥ 4 mm) and 200 samples from healthy sites of 14 patients with chronic periodontitis, as well as 200 samples from 3 periodontally healthy patients were obtained. The presence and levels of 11 pathogenic bacteria were determined using whole genomic DNA probes and the checkerboard method, computed for each site and then across sites within each subject group. Significance of differences in clinical and microbiological parameters among groups were examinated using the MannWhitney and Wilcoxon sign tests. The predominant species in all 600 samples included Corynebacterium diphtheriae, Enterococcus faecalis, Staphylococcus aureus, Acinetobacter baumannii and Escherichia coli. In general, most of the species were detected in greater prevalence and levels in sites with and without disease from patients with periodontitis in comparison to the periodontally healthy group. In particular, C. diphtheriae, E. coli, E. faecalis, Pseudomonas aeruginosa and S. aureus were significantly more prevalent and detected in higher counts in diseased sites of patients with periodontal disease compared to healthy subjects (p < 0.05). Clinical signs of disease presented a positive correlation with the species A. baumannii, Streptococcus pyogenes, E. coli, S. aureus and P. aeruginosa. In conclusion, "non-oral" pathogenic bacteria are detected in high prevalence and levels in periodontal sites of chronic periodontitis patients.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence of "non-oral" pathogenic bacteria in subgingival biofilm of subjects with chronic periodontitis

Souto¹,

Andrade²,

Uzeda³

et al. 2006

Braz. J. Microbiol.

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“…In addition to bacteraemia and metastatic inflammation [17], another possible pathway associating periodontal diseases to systemic inflammatory diseases may be through alterations in the gut microbiome. In individuals with periodontal diseases, the long-term swallowing of high doses of periodontal pathogenic microorganisms could induce a dysbiosis of the intestinal microbiota, favouring the establishment of an ‘inflamed’ microbiome in terms of composition and/or function.…”

Section: Discussionmentioning

confidence: 99%

“…The direct or indirect effects of circulating bacteria, inflammatory mediators and/or immune complexes from infected/inflamed periodontal tissues on other body sites are some of the main mechanisms that contribute to systemic inflammation [17]. Oral bacteria can enter the circulation and cause bacteraemia by actively crossing the periodontal epithelium [18–20], or by being inoculated through mechanical procedures, including periodontal debridement, flossing and brushing [21,22].…”

Section: Introductionmentioning

confidence: 99%

Defining the gut microbiota in individuals with periodontal diseases: an exploratory study

Lourenςo

Spencer

Alm

et al. 2018

Journal of Oral Microbiology

116

109

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Background: This exploratory study aimed to characterize the gut microbiome of individuals with different periodontal conditions, and correlate it with periodontal inflammation and tissue destruction.Methods: Stool samples were obtained from individuals presenting periodontal health (PH = 7), gingivitis (G = 14) and chronic periodontitis (CP = 23). The intestinal microbiome composition was determined by Illumina MiSeq sequencing.Results: A lower alpha-diversity in the gut microbiome of individuals with CP was observed, although no significant difference among groups was found (p > 0.01). Firmicutes, Proteobacteria, Verrucomicrobia and Euryarchaeota were increased, whereas Bacteroidetes were decreased in abundance in patients with periodontitis compared to PH. Prevotella (genus), Comamonadaceae (family) and Lactobacillales (order) were detected in higher numbers in G, while Bacteroidales (order) was predominant in PH (p < 0.01). Significant correlations (rho = 0.337–0.468, p < 0.01) were found between OTUs representative of periodontal pathogens and attachment loss. Mogibacteriaceae, Ruminococcaceae and Prevotella were able to discriminate individuals with periodontal diseases from PH (overall accuracy = 84%). Oral taxa were detected in high numbers in all stool samples.Conclusions: Individuals with periodontal diseases present a less diverse gut microbiome consistent with other systemic inflammatory diseases. High numbers of oral taxa related to periodontal destruction and inflammation were detected in the gut microbiome of individuals regardless of periodontal status.

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“…Moreover, daily bacteremias can ocur by even after toothbrushing, flossing and after dental procedures 10,11 . It is suspected that patients with periodontal disease may experience transient bacteremia multiple times per day 10,11,12 .…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Periodontal Disease and Alzheimer’s Disease

Orbak¹,

Öztürk²

2016

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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Alzheimer's disease(AD) is a neurodegenerative disease that effects elder people. As the age increases, the prevalance of Alzheimer's disease also raises. As AD, periodontitis is seen more often in elder people. Periodontal disease has been associated with some systemical diseases such as cardiovascular diasease(CVS), diabetes mellitus, rheumatoid arthritis and preterm birth. Latterly, it has been investigated if there is a connection between Alzheimer's diasease. This review's aim is, inspecting if the periodontal disease contributes to Alzheimer's disease at literacy.

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Systemic Diseases Caused by Oral Infection

Cited by 649 publications

References 130 publications

Prevalence of "non-oral" pathogenic bacteria in subgingival biofilm of subjects with chronic periodontitis

Prevalence of "non-oral" pathogenic bacteria in subgingival biofilm of subjects with chronic periodontitis

Defining the gut microbiota in individuals with periodontal diseases: an exploratory study

The Relationship Between Periodontal Disease and Alzheimer’s Disease

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