Systemic corticosteroids reduce the risk of cellophane membranes after retinal detachment surgery: a prospective randomized placebo-controlled double-blind clinical trial

Abstract

Early stages of PVR such as cellophane membranes after retinal detachment surgery can be reduced with corticosteroids in oral doses.

Profibrotic cytokines in aqueous humour correlate with aqueous flare in patients with rhegmatogenous retinal detachment

“…Another reason could be a biphasic effect of steroids, which are stimulatory on RPE cell proliferation at lower concentrations and inhibitory at higher concentrations 21. However, previous studies have shown that steroids reduce postoperative inflammation22 23 or reduce the risk of cellophane membranes after RD surgery 24…”

Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical consequences

“…Both strategies of retinopexy induce a pro-inflammatory environment that could explain the high risk as shown in experimental models Goldaracena et al, 1997;Pinon et al, 1992). Indeed, in a prospective, randomized, placebo-controlled, double-blind clinical trial performed to determine if prolonged administration of systemic corticosteroids would attenuate early stages of PVR, the application of transcleral cryocoagulation was associated with more cases developing epiretinal membranes in the placebo than the steroid group (Koerner et al, 2012). These findings reinforce the idea that the anti-inflammatory strategy could be one of the best options for preventing PVR.…”

Role of Caveolin-1 for Blocking the Epithelial-Mesenchymal Transition in Proliferative Vitreoretinopathy

“…10 Oral steroid intakes that supposedly suppress TGF-b activity did not robustly contribute to the prevention of PVR in surgical RD cases. 11,12 Therefore, a better understanding of the precise mechanism and the discovery of a novel therapeutic target for PVR is necessary.…”