Systemic blastomycosis in children

Steele, Russell W.; Abernathy, Rosalind S.

doi:10.1097/00006454-198307000-00011

Cited by 41 publications

(15 citation statements)

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“…Children make up 2%–11% of cases in previous studies ( 15 , 16 ). Published case reports and case series of pediatric blastomycosis highlight the potential for pulmonary, bone, and CNS disease, as well as neonatal disease and intrauterine transmission ( 6 , 15 – 20 ).…”

Section: Discussionmentioning

confidence: 92%

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Blastomycosis in Ontario, 1994–2003

Morris

Brophy

Richardson

et al. 2006

Emerg. Infect. Dis.

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Section: Discussionmentioning

confidence: 92%

“…Published case reports and case series of pediatric blastomycosis highlight the potential for pulmonary, bone, and CNS disease, as well as neonatal disease and intrauterine transmission ( 6 , 15 – 20 ). In our review, 13% of patients were <19 years of age.…”

Section: Discussionmentioning

confidence: 99%

Blastomycosis in Ontario, 1994–2003

Morris

Brophy

Richardson

et al. 2006

Emerg. Infect. Dis.

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“…14,15 A retrospective review of 70 pediatric patients with systemic blastomycosis from Arkansas showed that only 16% of patients exhibited secondary cutaneous findings. 16 Two subsequent series from the same region examined a total of 20 pediatric patients with blastomycosis infections, 5 of whom presented with secondary cutaneous findings; all patients identified with cutaneous findings also presented with pulmonary disease. 13,16 A separate 30-year retrospective review from Manitoba, Canada, identified 34 pediatric patients with blastomycosis, of whom 18% presented with cutaneous findings.…”

Section: Discussionmentioning

confidence: 99%

“…16 Two subsequent series from the same region examined a total of 20 pediatric patients with blastomycosis infections, 5 of whom presented with secondary cutaneous findings; all patients identified with cutaneous findings also presented with pulmonary disease. 13,16 A separate 30-year retrospective review from Manitoba, Canada, identified 34 pediatric patients with blastomycosis, of whom 18% presented with cutaneous findings. 17 Finally, a more recent 10-year review from Wisconsin identified 17 pediatric cases of blastomycosis; of these, 6 presented with cutaneous findings, 5 of whom had concurrent pulmonary disease.…”

Section: Discussionmentioning

confidence: 99%

Atypical Cutaneous Blastomycosis in a Child With Juvenile Idiopathic Arthritis on Infliximab

et al. 2015

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Blastomyces dermatitidis is a dimorphic fungus endemic to much of North America, particularly the soils of the midwestern and southeastern United States. Human infection typically occurs through inhalation of airborne conidia, which can be followed occasionally by dissemination to the skin, bone, genitourinary system, and central nervous system. A hallmark of the pathogen is that it can cause disease in both immunocompetent and immunosuppressed populations. Blastomycosis is rare in pediatric patients, with cutaneous manifestations occurring even less frequently. Here, we report the case of a 9-year-old boy on iatrogenic immunosuppression with infliximab and methotrexate for juvenile idiopathic arthritis who presented with a nonhealing, indurated plaque of his right ear with significant superficial yellow crusting in the absence of constitutional symptoms. After failing a prolonged course of topical and oral antibiotic therapy, biopsy and tissue culture revealed Blastomyces dermatitidis infection. The area cleared after treatment with oral fluconazole and withdrawal of infliximab. To our knowledge, this is the first report of a pediatric patient developing an infection with B dermatitidis after initiation of therapy with a tumor necrosis factor-a inhibitor. This case also highlights an unusual morphology of cutaneous blastomycosis in an iatrogenically immunosuppressed child.

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“…5 Although two of our above cases include children, pediatric cases in the literature are limited; one review reported only 70 pediatric cases in the literature between 1939 and 1983. 6 In the great majority of cases, infection occurs via inhalation of spores. Cellular immunity primarily controls the organisms once inhaled, but they may disseminate in their more resistant yeast form.…”

Section: Discussionmentioning

confidence: 99%