Systemic biochemical markers of joint metabolism and inflammation in relation to radiographic parameters and pain of the knee: data from CHECK, a cohort of early-osteoarthritis subjects

Spil, W.E. van; Nair, Sandhya; Kinds, M.B.; Emans, Pieter J.; Hilberdink, W.K.; Welsing, Paco M J; Lafeber, Floris P. J. G.

doi:10.1016/j.joca.2014.09.003

Cited by 33 publications

(26 citation statements)

References 44 publications

(21 reference statements)

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“…Earlier publications on these biomarkers in CHECK have demonstrated their associations with demographic variables 3,4 , their mutual associations 3,5 , and their associations with radiographic knee parameters and pain 6 . This time, we investigated to what extent these biomarkers reflected concurrent radiographic knee and hip OA and related to future incidence as well as progression of knee and hip OA during 5-year follow-up.…”

Section: Introductionmentioning

confidence: 97%

The ability of systemic biochemical markers to reflect presence, incidence, and progression of early-stage radiographic knee and hip osteoarthritis: data from CHECK

Spil

Welsing

Bierma-Zeinstra

et al. 2015

Osteoarthritis and Cartilage

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Section: Introductionmentioning

confidence: 97%

The ability of systemic biochemical markers to reflect presence, incidence, and progression of early-stage radiographic knee and hip osteoarthritis: data from CHECK

Spil

Welsing

Bierma-Zeinstra

et al. 2015

Osteoarthritis and Cartilage

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“…Serum cartilage oligomeric matric protein (sCOMP) is a non-collagenous protein resulting from cartilage breakdown, but is also present in other tissues such as tendon and synovial membrane. It has been found to be elevated in patients with knee osteoarthritis [ 5 ], and together with uCTXII, is considered one of the most consistent candidate biomarker associated with radiographic severity [ 7 ], radiographic incidence and progression of knee OA, and the incidence of painful radiographic knee OA [ 6 ]. YKL-40 (sYKL, also known as chitinase-3-like protein 1 or human cartilage glycoprotein-39) is produced in articular chondrocytes and synoviocytes and serum levels have been shown to correlate with the disease severity in OA [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Cartilage turnover and intra-articular corticosteroid injections in knee osteoarthritis

et al. 2018

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Intra-articular corticosteroid injections (IACI) are commonly used interventions for pain relief in patients with knee osteoarthritis (OA). Biomarkers may be helpful in further elucidating how IACI exert their effect. The aim of this study is to look at the response of biomarkers of cartilage and bone metabolism after IACI in knee OA. Eighty subjects with symptomatic knee OA [45% male, mean age (SD) 64 (11) years] underwent routine knee joint injection with 40 mg triamcinolone acetonide and 4 ml 1% lignocaine. Knee pain (as pain subscale of WOMAC VAS) and biomarkers [C-telopeptides of type-II collagen (uCTX-II), and N-telopeptides of type-I collagen in urine; cartilage oligomeric matrix protein (COMP), hyaluronic acid, N-terminal propeptide of type-IIA collagen, and human cartilage glycoprotein-39 (YKL-40) in serum] were measured at baseline and 3 weeks after IACI. Radiographic severity of disease was evaluated using knee radiographs. Median uCTX-II, a cartilage degradation marker, was lower at 3 weeks post IACI compared with baseline: 306.3 and 349.9 ng/mmol, respectively (p < 0.01), which remained significant after Bonferroni correction. Apart from a weak trend of lower sCOMP post IACI (p = 0.089), other biomarkers showed no change after IACI. Both baseline uCTX-II values and the change in uCTX-II from baseline to 3 weeks post injection correlated with radiographic severity of joint space narrowing, but not osteophyte grade. No association between uCTX-II and pain was observed. This observational study suggests that IACI in knee OA may reduce cartilage degradation in the short term.

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“…Indeed, the quest for improved imaging markers (including x-ray) is an active area of investigation. To date, most biochemical biomarker studies have focused on degradation or synthetic products of cartilage, bone or synovium and have yielded mixed results 3–7 . Conventional inflammatory markers such as C-reactive protein (CRP) have not consistently been associated with severity or progression of knee OA 2,8 .…”

Section: Introductionmentioning

confidence: 99%

Plasma levels of interleukin-1 receptor antagonist (IL1Ra) predict radiographic progression of symptomatic knee osteoarthritis

Attur

Statnikov

Samuels

et al. 2015

Osteoarthritis and Cartilage

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Objective Pro- and anti-inflammatory mediators, such as IL-1β and IL1Ra, are produced by joint tissues in osteoarthritis (OA), where they may contribute to pathogenesis. We examined whether inflammatory events occurring within joints are reflected in plasma of patients with symptomatic knee osteoarthritis (SKOA). Design 111 SKOA subjects with medial disease completed a 24-month prospective study of clinical and radiographic progression, with clinical assessment and specimen collection at 6-month intervals. The plasma biochemical marker IL1Ra was assessed at baseline and 18 months; other plasma biochemical markers were assessed only at 18 months, including IL-1β, TNFα, VEGF, IL-6, IL-6Rα, IL-17A, IL-17A/F, IL-17F, CRP, sTNF-RII, and MMP-2. Results In cross-sectional studies, WOMAC (total, pain, function) and plasma IL1Ra were modestly associated with radiographic severity after adjustment for age, gender and BMI. In addition, elevation of plasma IL1Ra predicted joint space narrowing (JSN) at 24 months. BMI did associate with progression in some but not all analyses. Causal graph analysis indicated a positive association of IL1Ra with JSN; an interaction between IL1Ra and BMI suggested either that BMI influences IL1Ra or that a hidden confounder influences both BMI and IL1Ra. Other protein biomarkers examined in this study did not associate with radiographic progression or severity. Conclusions Plasma levels of IL1Ra were modestly associated with the severity and progression of symptomatic knee osteoarthritis in a causal fashion, independent of other risk factors. The findings may be useful in the search for prognostic biomarkers and development of disease-modifying OA drugs.

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Systemic biochemical markers of joint metabolism and inflammation in relation to radiographic parameters and pain of the knee: data from CHECK, a cohort of early-osteoarthritis subjects

Cited by 33 publications

References 44 publications

The ability of systemic biochemical markers to reflect presence, incidence, and progression of early-stage radiographic knee and hip osteoarthritis: data from CHECK

The ability of systemic biochemical markers to reflect presence, incidence, and progression of early-stage radiographic knee and hip osteoarthritis: data from CHECK

Cartilage turnover and intra-articular corticosteroid injections in knee osteoarthritis

Plasma levels of interleukin-1 receptor antagonist (IL1Ra) predict radiographic progression of symptomatic knee osteoarthritis

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