Systemic Autoimmune, Rheumatic Diseases and Coinciding Psoriasis: Data from a Large Single‐Centre Registry and Review of the Literature

Abstract

Psoriasis is a systemic immune-inflammatory disease characterized by chronic or recurrent skin symptoms, psoriatic arthritis, enthesopathy, and uveitis. Psoriasis has recently been published to appear with various autoimmune disorders, but the coexistence has been systematically reviewed by only few studies until now. In the present study, charts and electronic database of 4344 patients with various systemic autoimmune disorders, under regular medical control at our department, were reviewed retrospectively searching for association with psoriasis. Hereby, we demonstrate 25 psoriatic patients coinciding with various systemic autoimmune diseases. The coexistence of psoriasis and autoimmune diseases resulted in the worsening of the clinical outcome of the autoimmune diseases as indicated by higher frequency and dosages of glucocorticoid use, need for biologicals, and other comorbidities. These results suggest common environmental and genetic background as well as therapeutic possibilities in the future.

Psoriasis Is Associated With an Increased Risk of Hospitalization for Systemic Lupus Erythematosus: Analysis of the National Inpatient Sample Database

“…Regarding the racial distribution, more than half of the patients with SLE and Ps were White, while most of the patients in the SLE without Ps cohort were Black. These are in keeping with the findings of studies that suggest that Ps and SLE are most prevalent amongst middle-aged patients, with SLE particularly more common in African-American females while Ps typically affects White patients [ 7 - 8 , 22 - 24 ].…”

“…However, the upregulation of the Th17 immune pathway is a mechanism shared by both diseases. IL-17, IL-22, and IL-23, produced by Th17 cells, have been shown to play a major role in maintaining chronic inflammation in both psoriasis and SLE, and an upregulated Th17 immunologic response may explain the association between both conditions, as well as provide a therapeutic target for management of concomitant Ps and SLE [8,12,[20][21][22].…”

Is psoriasis an autoimmune disease? Interpretations from an immunofluorescence‐based study

“…However, anti‐dsDNA, anti‐Smith and antinuclear ribonucleoprotein antibodies were not detected in any of their patients. It has been noted that there is an increased prevalence of some autoimmune diseases like rheumatoid arthritis, celiac disease and Crohn's disease with psoriasis . Although, this association indicates a possible relation of psoriasis with other autoimmune diseases but is not sufficient enough to establish a definite autoimmune etiology.…”

Efecto de la dexametasona sobre el mecanismo inflamatorio que subyace en el asma

“…Desde su descubrimiento, la terapia con corticoides es utilizada frecuentemente en enfermedades cutáneas, oculares, del tracto digestivo, en la insuficiencia suprarrenal, en enfermedades autoinmunes y del tejido conectivo o en procesos cancerosos (96)(97)(98)(99). Además, desde 1950, cuando se utilizó por primera vez la cortisona en aerosol en el tratamiento del asma bronquial (100), los corticoides constituyen la base del tratamiento en las enfermedades alérgicas y en el asma (101)(102)(103).…”