Is psoriasis an autoimmune disease? Interpretations from an immunofluorescence‐based study

Abstract

No significant association between psoriasis and immunoreactant deposition as well as autoantibody seroprevalence was observed, thereby refuting a definite autoimmune basis for psoriasis.

Methotrexate restores the function of peripheral blood regulatory T cells in psoriasis vulgaris via the CD73/AMPK/mTOR pathway

“…Although aberrant activation of immune responses has been observed in patients with psoriasis, the exact mechanism of action remains unclear . We first used CSFE assay to analyse the proliferation of Teff cells.…”

Interleukin-22 and Its Correlation with Disease Activity in Plaque Psoriasis

“…Although psoriasis is considered to be a prototypical T-cell-dependent disease with aberrant response of activated T-lymphocytes against some hitherto undefined cutaneous antigen, the exact events leading to such activation and nature of the putative autoantigen are still a matter of controversy (Anand et al 2017; Sticherling 2016). …”

Neutrophil-rich, noncollagenous 16A domain-negative bullous pemphigoid associated with psoriasis

“…7 Patients with psoriasis alone may have a positive DIF result, but this is limited to granular deposition of C5b-9. 4 Thus, the second DIF in this case, which revealed the linear deposition of IgG and C3, reflected a true-positive result for BP because this pattern is not seen in patients with psoriasis alone. 4 In this case, the repeat DIF yielded a positive result, whereas ELISA yielded persistently negative results for BP180 and BP230 IgG reactivity.…”

“…1 The association between BP and psoriasis has been frequently reported. 2 The most common histopathologic and serologic findings in patients with BP include a subepidermal blister with eosinophils 3,4 and BP180-noncollagenous 16A (NC16A) reactivity, demonstrated using enzyme-linked immunosorbent assay (ELISA). 1 Uncommonly, the histopathology of BP may be rich in neutrophils.…”