Systemic Antivirals in Dermatology

Peranteau, Andrew J.; Vangipuram, Ramya; Sharghi, Kevin G.; Tyring, Stephen K.

doi:10.1007/978-3-319-66884-0_41

Cited by 2 publications

(4 citation statements)

References 62 publications

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“…The pharmacokinetic profile of acyclovir is similar for both administrations. It is observed that in the Wistar rats treated with pseudoboehmite and acyclovir, the acyclovir content increases after 1 h of administration reaching a peak after ~ 2 h. The result is similar to the data reported in the literature 23 . However, in the first 3 h, the content of acyclovir was higher in the blood of the Wistar rats in which the drug was not administered with the pseudoboehmite.…”

Section: Analysis Of Acyclovir Insupporting

confidence: 90%

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Pseudoboehmite as a drug delivery system for acyclovir

Peres

Sousa

Oliveira

et al. 2021

Sci Rep

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Herpes simplex virus is among the most prevalent sexually transmitted infections. Acyclovir is a potent, selective inhibitor of herpes viruses and it is indicated for the treatment and management of recurrent cold sores on the lips and face, genital herpes, among other diseases. The problem of the oral bioavailability of acyclovir is limited because of the low permeability across the gastrointestinal membrane. The use of nanoparticles of pseudoboehmite as a drug delivery system in vitro assays is a promising approach to further the permeability of acyclovir release. Here we report the synthesis of high purity pseudoboehmite from aluminium nitrate and ammonium hydroxide containing nanoparticles, using the sol–gel method, as a drug delivery system to improve the systemic bioavailability of acyclovir. The presence of pseudoboehmite nanoparticles were verified by infrared spectroscopy, transmission electron microscopy, and X-ray diffraction techniques. In vivo tests were performed with Wistar rats to compare the release of acyclovir, with and without the addition of pseudoboehmite. The administration of acyclovir with the addition of pseudoboehmite increased the drug content by 4.6 times in the plasma of Wistar rats after 4 h administration. We determined that the toxicity of pseudoboehmite is low up to 10 mg/mL, in gel and the dried pseudoboehmite nanoparticles.

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Section: Analysis Of Acyclovir Insupporting

confidence: 90%

“…In a recent study using magnetite for acyclovir release 22 , when acyclovir is administered orally, it is partially absorbed from the gastrointestinal tract and approximately only 15-30 wt% of the dose is absorbed. The maximum plasma concentrations are reached in 1-2 h, and administration is usually required twice daily 23 .…”

mentioning

confidence: 99%

Pseudoboehmite as a drug delivery system for acyclovir

Peres

Sousa

Oliveira

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The pharmacokinetic pro le of acyclovir is similar to both administrations. It is observed that in the Wistar rats treated with pseudoboehmite and acyclovir, the acyclovir content increases after 1 h of administration with a peak at around 2 h. The result is similar to the data of literature [23]. Although in the rst 3 hours the content of acyclovir was higher in the blood of the Wistar rats in which the drug was not administered with the pseudoboehmite.…”

Section: Analysis Of Acyclovir In Wistar Rat Bloodsupporting

confidence: 88%

“…In a recent study using magnetite for acyclovir release [22], when acyclovir is administered orally, it is partially absorbed from the gastrointestinal tract and approximately only 15 ~ 30 wt% of the dose is absorbed. The maximum plasma concentrations are reached in 1-2 hours, and administration is usually required twice daily [23].…”

Section: Hui Et Alii Observed That the Combination Of Acyclovir And Dmentioning

confidence: 99%

Pseudoboehmite as a drug delivery system for acyclovir

Peres

Sousa

Oliveira

et al. 2021

Preprint

View full text Add to dashboard Cite

Herpes simplex virus is among the most prevalent sexually transmitted infections. Acyclovir is a potent, selective inhibitor of herpes viruses and is indicated for the treatment and management of recurrent cold sores on the lips and face, genital herpes, among other diseases. The problem of the oral bioavailability of acyclovir is limited because of low permeability across the gastrointestinal membrane. Based on experiments using nanoparticles of pseudoboehmite as a drug delivery system in vitro assays it was concluded that pseudoboehmite could be used for acyclovir release. We report the synthesis of high purity pseudoboehmite from aluminium nitrate and ammonium hydroxide containing nanoparticles. Pseudoboehmite was characterized by several techniques. In vivo tests were performed with Wistar rats to compare the release of acyclovir, with and without the addition of pseudoboehmite. The administration of acyclovir with the addition of pseudoboehmite increased the drug content in the plasma of Wistar rats after 4 h administration. The toxicity of pseudoboehmite was also evaluated using the Caco-2 cell line (ATCC).

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Systemic Antivirals in Dermatology

Cited by 2 publications

References 62 publications

Pseudoboehmite as a drug delivery system for acyclovir

Pseudoboehmite as a drug delivery system for acyclovir

Pseudoboehmite as a drug delivery system for acyclovir

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