Systemic antiviral drugs used in ophthalmology

Teich, Steven; Cheung, Tony; Friedman, Alan H.

doi:10.1016/0039-6257(92)90003-c

Cited by 37 publications

(11 citation statements)

References 408 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since intraocular inflammation caused by viruses can be progressive and devastating,5-7 the timely and precise diagnosis and specific antimicrobial therapy may be sight saving 8. The aqueous humour analysis contributes to this goal.…”

mentioning

confidence: 99%

Diagnostic anterior chamber paracentesis in uveitis: a safe procedure?

Lelij¹,

Rothová²

1997

British Journal of Ophthalmology

122

View full text Add to dashboard Cite

Background-DiVerentiation between infectious and non-infectious uveitis is of crucial value for accurate management of patients with uveitis. Tests performed on aqueous humour yield more relevant information than those done in serum. The objective of this study was to evaluate whether the aqueous humour tap for diagnostic purposes is a safe procedure to perform in uveitis patients. Methods-In this retrospective study 361 patients with uveitis, who underwent a diagnostic anterior chamber paracentesis in an outpatient clinic, were investigated. 72 of the 361 patients were examined 30 minutes after the puncture. The site of the paracentesis, the depth of the anterior chamber, and cells in the anterior chamber were examined. All 361 patients were evaluated within 2 weeks after the paracentesis was performed. The final follow up period varied from 6 months to more than 3 years. The clinical data were analysed with the emphasis on the occurrence of cataract and a history of corneal infections or endophthalmitis. Results-In this series no serious side eVects such as cataract, keratitis, or endophthalmitis were observed. The depth of the anterior chamber of all evaluated patients was restored after 30 minutes. In five out of 72 cases (three AIDS patients with cytomegalovirus retinitis and two patients with anterior uveitis due to herpes simplex virus) a small hyphaema was observed 30 minutes after the paracentesis took place. Conclusion-Anterior chamber paracentesis appears to be a safe procedure in the hands of an experienced ophthalmologist. (Br J Ophthalmol 1997;81:976-979)

show abstract

mentioning

confidence: 99%

Diagnostic anterior chamber paracentesis in uveitis: a safe procedure?

Lelij¹,

Rothová²

1997

British Journal of Ophthalmology

122

View full text Add to dashboard Cite

show abstract

“…36 Unlike ARN syndrome, the clinical course is chronic and indolent with minimal or absent vitreous inflammation. CMV retinitis manifests initially with 1 or 2 patches of white granular retinal lesions.…”

Section: Differential Diagnosismentioning

confidence: 95%

“…Acyclovir is a guanine analog with activity against VZV, HSV-1, HSV-2, and Epstein-Barr virus. 36 Acyclovir selectively inhibits DNA polymerase, requiring a virus-specific thymidine kinase for activation. Thus, it targets only HSV-1, HSV-2, and VZV infected cells and limits toxicity to human cells.…”

Section: Diagnostic Toolsmentioning

confidence: 99%

Acute Retinal Necrosis: An Overview

Chang

Young

2007

International Ophthalmology Clinics

View full text Add to dashboard Cite

“…First, systemic therapy with acyclovir is selected because of its efficacy and safety. Acyclovir is a guanine analog with activity against HSV-1, HSV-2 and VZV (Teich et al, 1992). It selectively inhibits DNA polymerase and requires a virus-specific thymidine kinase for activation.…”

Section: Antiviral Therapymentioning

confidence: 99%

Herpetic Viral Retinitis

Noma¹

2013

American Journal of Virology

View full text Add to dashboard Cite

Human Herpes Virus (HHV) is a DNA virus and is the most important viral pathogen causing intraocular inflammation. HHV is classified into types 1-8. Among these types, HHV-1, HHV-2, HHV-3 Varicella Zoster Virus (VZV) and HHV-5 Cytomegalovirus (CMV) are known to cause herpetic viral retinitis, including acute retinal necrosis and CMV retinitis. Herpes viral retinitis can be diagnosed from characteristic ocular findings and viral identification by PCR of the aqueous humor. Recently, therapy has become more effective than in the past. Herpes viral retinitis gradually progresses if appropriate treatment is not provided with regard to the patient's immune status. Further advances in diagnostic methods and treatment are required in the future.

show abstract

Systemic antiviral drugs used in ophthalmology

Cited by 37 publications

References 408 publications

Diagnostic anterior chamber paracentesis in uveitis: a safe procedure?

Diagnostic anterior chamber paracentesis in uveitis: a safe procedure?

Acute Retinal Necrosis: An Overview

Herpetic Viral Retinitis

Contact Info

Product

Resources

About