Systemic Antihypertensive Medication and Incident Open-angle Glaucoma

Antihypertensive Medication Postpones the Onset of Glaucoma

“…Previous studies have shown an association between antihypertensive medication and glaucoma (but the evidence is still scarce). [19][20][21]35 However, no previous study has investigated the causal effect of antihypertensive medication on glaucoma.…”

“…Previous studies have shown an association between antihypertensive medication and glaucoma (but the evidence is still scarce). [19][20][21]35 However, no previous study has investigated the causal effect of antihypertensive medication on glaucoma.Although the overall risk of treatment with antiglaucomatous drugs is increased in patients taking antihypertensive medication, we show that commenced treatment with antihypertensive drugs postpones the onset of glaucoma, or treatment with an antiglaucomatous drugs, and leads to a reduction in the trend of glaucoma by around 43%.We cannot know if the estimates could be affected by an increased avoidance of glaucomatous diagnostics after the onset of antihypertensive treatment. Furthermore, the present analysis assumes that there is no algorithm in the medical care system that leads to patients who start antihypertensive medication being more or less likely to be examined for glaucoma.…”

“…5,[17][18][19] Recognized high BP is treated with many different antihypertensive medications, and growing evidence acknowledges that such treatment is associated with glaucoma. [20][21][22] In this matter, antihypertensive medication may conflict with ocular perfusion and autoregulation. 20,23 Although studies have shown a correlation between antihypertensive treatment and glaucoma, these studies have mostly been trials in small numbers of patients with minimal follow-up periods.…”

“…[20][21][22] In this matter, antihypertensive medication may conflict with ocular perfusion and autoregulation. 20,23 Although studies have shown a correlation between antihypertensive treatment and glaucoma, these studies have mostly been trials in small numbers of patients with minimal follow-up periods. 1,14,24 Moreover, to the best of our knowledge, no previous study has benefited from a complete data sample from an entire population norimportantly-estimated the causal effect of antihypertensive treatment on the risk of developing glaucoma.…”

24-hour Intraocular Pressure and Ocular Perfusion Pressure in Glaucoma

“…For example, although systemic calcium channel blockers may enhance ocular blood flow, 59 there was an increased incidence of glaucoma in patients receiving these medications in the Rotterdam Eye Study. 86 Despite the recognition of circadian IOP and OPP as important factors in OAG, future research will need to address a number of issues. Because glaucoma represents a heterogeneous group of related optic neuropathies, there may be subgroups of patients in whom vascular factors are important.…”