Systemic and Topical Fresh-Frozen Plasma Treatment in a Newborn With Ligneous Conjunctivitis

Gürlü, Vuslat; Demir, Muzaffer; Alimgil, Murat Levent; Erda, Sait

doi:10.1097/ico.0b013e318162a8e0

Cited by 24 publications

(14 citation statements)

References 10 publications

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“…This treatment facilitates elimination of the membranes by softening them, but its cost is rather high. Treatment with topical fresh frozen plasma prepared from fresh frozen plasma resulted in hopeful outcomes (17). In our case, marked reduction was obtained with this treatment and no new membrane formation was observed.…”

Section: Discussionmentioning

confidence: 68%

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2012

Tpa

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Sum maryLigneous conjunctivitis is a rare form of idiopathic membranous conjunctivitis. It occurs with type 1 plasminogen deficiency and is characterized by development of firm, fibrin-rich, woody-like, recurrent pseudomembranous lesions mainly on the tarsal conjunctiva. It may occur in other mucous membranes including oral cavity, tracheobronchial tree and upper gastrointestinal tract in addition to the conjunctiva. Due to plasminogen deficiency there is a defect in destruction of fibrin plaque which develops on the damaged mucosa as a result of minor trauma. Although autosomal recessive inheritence is described, most of the cases are sporadic. Generally, it develops during infancy and childhood, but can occur at any age. A 4 year-old male infant presented to the Opthalmology department with pink-red membranous lesion on his left eye extending from the conjunctiva to the iris. Histopathologic evaluation of the excised material was compatible with ligneous conjunctivitis and the diagnosis was confirmed with significantly decreased level of plasminogen in the patient. Despite topical prednisolone and cyclosporin treatment the lesion recurred. The patient was consulted with a hematologist and systemic and topical fresh frozen plasma (FFP) were administered. The case was discussed in terms of its histopathologic features and good response to FFP treatment in company with the literature. (Turk Arch Ped 2012; 47: 131-3)

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Section: Discussionmentioning

confidence: 68%

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2012

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“…Pergantou et al and Gürlü et al have declared that the simultaneous application of systemic and topical FFP was effective in treating ligneous conjunctivitis and preventing recurrences (2,3) . The risks of FFP include hemolysis, infections, transfusion-related acute lung injury, allergic reactions, and anaphylaxis.…”

Section: Discussionmentioning

confidence: 99%

“…Systemic treatment also requires hospitalization and intravenous application. Another drawback of FFP is its short half-life (2,3,7,8) . To minimize these unwanted effects and difficulties, we decided to use only topical FFP as eye drops in this patient.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Successful treatment of ligneous conjunctivitis with topical fresh frozen plasma in an infant

Tunay¹,

Özdemir²,

Acar³

et al. 2015

Arquivos Brasileiros De Oftalmologia

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“…Topical use of heparin, corticosteroids, cyclosporine, azathioprine, hyaluronidase and α-chymothrypsin has been used with limited success [3,8,9]. Although the topical and systemic administration of plasminogen concentrates in clinical trials has been proved effective in treating these lesions [3,8], they are not available on the international market while the use of fresh frozen plasma (FFP) systemically and topically was chosen in some cases with different results [4,11].…”

Section: Introductionmentioning

confidence: 99%