Management of ligneous conjunctivitis in a child with plasminogen deficiency

Abstract

Since surgical excision of the conjunctival pseudomembranes alone in patients with LC does not protect from recurrences, the perioperative administration of FFP, both systemically and topically improves the outcome. Furthermore, the long-term application of topical FFP preparations seems to prevent recurrences and has a protective effect on the vision of these patients.

Successful treatment of ligneous conjunctivitis with topical fresh frozen plasma in an infant

“…Pergantou et al and Gürlü et al have declared that the simultaneous application of systemic and topical FFP was effective in treating ligneous conjunctivitis and preventing recurrences (2,3) . The risks of FFP include hemolysis, infections, transfusion-related acute lung injury, allergic reactions, and anaphylaxis.…”

“…Systemic treatment also requires hospitalization and intravenous application. Another drawback of FFP is its short half-life (2,3,7,8) . To minimize these unwanted effects and difficulties, we decided to use only topical FFP as eye drops in this patient.…”

“…Plasminogen deficiency is a common cause of ligneous conjunctivitis (1)(2)(3)(4) ; this deficiency can affect not only the conjunctiva but also the other mucous membranes of the body. such as those of the oral mucosa, nasopharynx, trachea, female genital tract, and duodenum.…”

“…Several therapeutic modalities have been reported for the treatment of ligneous conjunctivitis and prevention of recurrences. However, no consensus has been gained on the treatment regimen (1,3) . The efficacy of topically applied fresh frozen plasma (FFP) together with subconjunctival FFP has been previously demonstrated in a patient with ligneous conjunctivitis (6) .…”

Ligneous conjunctivitis in a patient of juvenile colloid milia: A rare association

“…Management includes topical plasminogen concentrate,[3] topical fresh frozen plasma,[5] with systemic fresh frozen plasma,[67] topical heparin,[58910] with topical corticosteroids or alpha chymotrypsin,[1] topical cyclosporine A with amniotic membrane,[10] systemic low-dose lys-plasminogen,[13] surgical excision of pseudomembrane, which has high recurrence rates.…”