Systemic and Local Management of Burn Wounds

Vigani, Alessio; Culler, Christine A.

doi:10.1016/j.cvsm.2017.06.003

Cited by 35 publications

(23 citation statements)

References 59 publications

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“…Regarding description of the wound depth, Yaman et al reported that their second-degree skin burns created a full-thickness wound. However, definition of second-degree burn is specific to a burn that caused a deep partial-thickness wound on the skin [61][62][63]. Moreover, four studies [14,41,42,44] did not specify any details about the depth of wound.…”

Section: Discussionmentioning

confidence: 99%

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Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing in an In Vivo Animal Model: A Comprehensive Review

Sallehuddin

Nordin

Idrus

2020

IJERPH

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Nigella sativa (NS) has been reported to have a therapeutic effect towards skin wound healing via its anti-inflammatory, tissue growth stimulation, and antioxidative properties. This review examines all the available studies on the association of Nigella sativa (NS) and skin wound healing. The search was performed in Medline via EBSCOhost and Scopus databases to retrieve the related papers released between 1970 and March 2020. The principal inclusion criteria were original article issued in English that stated wound healing criteria of in vivo skin model with topically applied NS. The search discovered 10 related articles that fulfilled the required inclusion criteria. Studies included comprise different types of wounds, namely excisional, burn, and diabetic wounds. Seven studies unravelled positive results associated with NS on skin wound healing. Thymoquinone has anti-inflammatory, antioxidant, and antibacterial properties, which mainly contributed to wound healing process.

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Section: Discussionmentioning

confidence: 99%

“…Burn injury has been associated with an increase in oxidative stress in the wound bed [60]. Consequently, the use of antioxidants significantly decreases burn mortality [61]. Using burn and excisional injury in a rat model, NS and TQ treatments lead to significantly high TAS and low TOS levels proving good antioxidant properties.…”

Section: Biochemical Analysismentioning

confidence: 99%

Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing in an In Vivo Animal Model: A Comprehensive Review

Sallehuddin

Nordin

Idrus

2020

IJERPH

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“…Managing a patient with severe burn injuries is a long-term process. The management addresses both local wound care and the immediate and progressive systemic response of injury [ 27 ]. Therefore, burns are among the most expensive traumatic injuries due to prolonged hospitalization, rehabilitation, physiotherapy costs and wound dressings.…”

Section: ⧉ Discussionmentioning

confidence: 99%

Nanoparticle-functionalized dressings for the treatment of third-degree skin burns – histopathological and immunohistochemical study

Liliac

Popescu²,

Văduva³

et al. 2021

Rom J Morphol Embryol

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Skin burns are one of the most common injuries associated with increased morbidity and mortality, especially in the children and the elderlies. Severe burns, especially, result in a systemic immune and inflammatory response, which may reflect in multiple organ insufficiency, and a fast and effective local restorative process is essential for functionality recovering, as well as for interrupting the generalized systemic response. We have aimed here to assess the effect of different wound dressings in what it regards the morphology and clinical restoration after a skin burn. On a rat animal model, we have evaluated the macroscopic and histopathological features of controlled third degree skin burns in control animals versus treatments with local dressings of silver sulfadiazine (SDA) cream, simple gel (G), gel + silver nanoparticles (AgNPs) (G+NPS), gel + exosomes (G+EXO) and gel + AgNPs + exosomes (Gel+NPS+EXO), at 14 days and, respectively, 21 days after the lesion. Tissue fragments were harvested and processed for histopathology and immunohistochemistry. Immunofluorescence was utilized to evaluate the maturity of underlaying granulation tissue based on double stainings for smooth muscle actin (SMA) and cluster of differentiation 31 (CD31). Our study showed variability in what it regards the vessel density and immunoexpression of SMA between the treatments, and image analysis revealed that most SMA reduction and blood vessel density reduction in the maturing granulation tissue occurred for the G+NPS and G+NPS+EXO treatments. A complete re-epithelization was also observed for the G+NPS+EXO treatment. Overall, our results show that improved topic treatments promote faster re-epithelization and reparation of the dermis after skin burn lesions, providing thus an avenue for new treatments that aim both local recuperation and systemic infection prevention.

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“…Oxidative stress is vital due to its association with burn wounds (Nielson et al, 2017). Moreover, Vigani et al (2017) mentioned that antioxidants could reduce the mortality caused by burn injury. Three studies which are done separately by Han et al (2017), Kumandas et al (2019), and Selçuk et al (2013 had observed low TOS level and high TAS level when black seeds and TQ were used for the rat model that a burn and excisional injuries had inflicted.…”

Section: Discussionmentioning

confidence: 99%

review of black seed extract as an agent in the wound healing process

Zaid

Hanafi

Haris

2021

JoP

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Introduction: Nigella Sativa or Black Cumin is an annual flowering plant that can be used for wound treatment. In the treatment for wound healing, this plant contains many beneficial components that can help with the treatment but this plant utilisation in the medical field is still limited. This review will provide an overview of the advantages when this plant is used in the wound healing treatment. Method: The review was based on the ROSES protocol, and the databases used were ScienceDirect, PubMed, and Google Scholar. After the search, only 11 papers had been chosen to be included in the results and they were divided into four main themes that were used for the analysis of the results. Results: The themes were gross analysis, microscopic analysis, biochemical analysis and antimicrobial analysis. Conclusion: In conclusion, the black seed extract contains several valuable properties, such as antimicrobial and antioxidant properties, which help improve the wound healing process. Further study needs to be done to discover more potential of Nigella Sativa in treating the wound.

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Systemic and Local Management of Burn Wounds

Cited by 35 publications

References 59 publications

Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing in an In Vivo Animal Model: A Comprehensive Review

Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing in an In Vivo Animal Model: A Comprehensive Review

Nanoparticle-functionalized dressings for the treatment of third-degree skin burns – histopathological and immunohistochemical study

review of black seed extract as an agent in the wound healing process

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