Systemic acute-phase reactants, C-reactive protein and haptoglobin, in adult periodontitis

Abstract

SUMMARYCapture ELISAs with biotinylated monospecific antibodies were developed to detect both C-reactive protein (CRP) and haptoglobin (Hp) in serum of adult periodontitis (AP) patients and normal subjects. Each acute-phase reactant was significantly increased in serum from AP patients with CRP at 9 : 12 Ϯ 1 : 61 mg/l versus 2 : 17 Ϯ 0 : 41 mg/l (P < 0 : 001) and Hp at 3 : 68 Ϯ 0 : 37 g/l versus 1 : 12 Ϯ 0 : 78 g/l (P < 0 : 001). Assessment of clinical characteristics of the patients' periodontal disease indicated that CRP and Hp levels were significantly increased in patients with the most frequent disease active episodes (P < 0 : 02 and P < 0 : 001, respectively). Longitudinal examination of the Hp levels showed a significant decrease following scaling and root planing (3 . 68 versus 2 . 38 g/l; P < 0 : 01). After a 2-year administration of 50 mg/b.i.d. Flurbiprofen (a non-steroidal anti-inflammatory drug), significantly decreased Hp levels were noted (P < 0 : 005). CRP levels declined by 35-40% after 1-2 years of treatment with the drug (P < 0 : 05). The findings indicated that localized infections resulting in increased inflammation and tissue loss in the periodontium elicit systemic host changes manifest by increases in two acute-phase reactants. The conclusions are that either these molecules are formed locally and distributed to the serum, or these presumably localized infections impact upon the systemic components of the host protective responses.

A Clinical Study on Dental Air Force Home Dental Cleaning System on Adult Chronic Periodontitis Patients and its Assessment to C-Reactive Protein Levels

“…This study found a similar correlation with the previous studies where they found as positive correlation between CRP and periodontitis patients. [6][7][8] In this study, we observed a significant improvement in gingival score and plaque score following scaling and root planing (SRP), as documented in previous study 9 and also this study correlates with the previous study conducted and found a significant decrease in serum CRP, but only after a period of 6 months. 10 Observational nonexperimental studies have found similar …”

Human serum haptoglobin is toxic to Plasmodium falciparum in vitro

“…Our results show that haptoglobin has a deleterious effect on the growth of P. falciparum in vitro at concentrations observed physiologically during the acute phase response [17], [18]. Evidence to support a role for an anti-parasitic effect of haptoglobin in vivo comes from experiments demonstrating that peak parasitaemia and peak parasite burden were greater in haptoglobin knock-out mice infected with P. berghei and P. chabaudi compared to wild type mice [11].…”

Effect of Smoking on Levels of Calcium, Magnesium and Blood Parameters in Patients With Chronic Periodontitis.

“…(31)(32)(33). It is well established that cigarette smoking is the major preventable risk factor for periodontal disease (34).With a comparable amount of plaque, smokers show deeper probing depths (35), greater attachment loss (36), and more bone loss. Erdemir et al (31)concluded that cigarette smoking may lead to anemia of chronic disease in subjects with chronic periodontitis.…”