Systematic review on the first line treatment of amphotericin B in critically ill adults with candidemia or invasive candidiasis

Keane, Seán; Geoghegan, Pierce; Póvoa, Pedro; Nseir, Saad; Rodríguez, Alejandro; Martín‐Loeches, Ignacio

doi:10.1080/14787210.2018.1528872

Cited by 21 publications

(23 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, the nephrotoxic effect of existing antifungal agents, particularly of AmB, has been extensively studied using in vitro and in vivo models (Van Etten et al, 1993). Combination therapy with caspofungin and voriconazole or liposomal amphotericin B (L-AmB) are considered as another first-line choice of antifungals in critically ill patients with invasive candidiasis (Keane et al, 2018). Although the newer antifungals L-AmB and caspofungin have considerably lower nephrotoxicity; infusion-related adverse reactions and renal dysfunction are still common (Olson et al, 2008;Felton et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Predictive Nephrotoxicity Profiling of a Novel Antifungal Small Molecule in Comparison to Amphotericin B and Voriconazole

et al. 2020

View full text Add to dashboard Cite

Background and Purpose: Candida albicans is the major fungal species associated with superficial mucosal infections such as oral candidiasis as well as systemic mycoses with high morbidity and mortality. On top of the rising drug resistance, currently available antifungal agents have significant adverse effects. Nephrotoxicity is the major treatment complication associated with antifungal agents.Recently, we discovered a novel antifungal small molecule SM21 with promising antifungal activity. The present study aimed to comparatively evaluate the in vivo and in vitro nephrotoxicity of SM21 comparing with Amphotericin B and voriconazole. Experimental Approach: Nephrotoxicity of SM21 and its analogue were comparatively evaluated with Amphotericin B (AmB) and voriconazole. Immortalized human kidney proximal tubule epithelial cells (HK-2) were used for in vitro analysis of nephrotoxicity using cytotoxicity assays and qPCR gene expression analysis (Kim-1/HAVcr-1, CASP3). Sprague Dawley (SD) rat model was used to evaluate the nephrotoxicity in vivo using classical (SCr and BUN) and next-generation kidney injury urinary biomarkers (Kim-1, CLU, ALB, NGAL, b 2M, and Cys C) alongside histopathological and immunohistochemical standards. Key Results: AmB treatment showed a stronger cytotoxic impact on HK-2 viability and gene expression of cell death markers (Kim-1/HAVcr-1, CASP3) compared with SM21 and SM21 analogue in vitro (P < 0.01). In vivo data further demonstrated that SM21 did not significantly increase classical as well as novel nephrotoxic biomarkers, and minimal renal tubular necrosis and abnormalities were observed (15 mg kg −1 BW/day). Conclusions and Implications: SM21 had a significantly better safety profile in terms of nephrotoxicity with no major tubular epithelial abnormalities observed in kidney cells and no augmentation of kidney injury biomarkers compared to AmB. Kim-1 and CLU were the most sensitive biomarkers for detection of AmB-induced kidney damage. Future clinical

show abstract

Section: Introductionmentioning

confidence: 99%

Predictive Nephrotoxicity Profiling of a Novel Antifungal Small Molecule in Comparison to Amphotericin B and Voriconazole

et al. 2020

View full text Add to dashboard Cite

show abstract

“…MIC > 2) or to the small number of samples tested. Since AmB and echinocandins are the first line of treatment for Candida fungaemia (Keane et al 2018;Demir et al 2019), resistance to these drugs should be not underestimated and needs to be further investigated using molecular approaches. The co-habitation of humans and laying hens and/or eggs may expose humans to multidrug-resistant and virulent yeasts.…”

Section: Discussionmentioning

confidence: 99%

Virulence and in vitro antifungal susceptibility of Candida albicans and Candida catenulata from laying hens

et al. 2020

View full text Add to dashboard Cite

In spite of evidence that domestic and wild birds may act as carriers of human pathogenic fungi, data on the role of laying hens as reservoirs of drug resistant and virulent yeasts is lacking. Here, we assess several virulence factors (phospholipase and haemolysin activity) and the antifungal susceptibility profiles of 84 Candida albicans and 17 Candida catenulata strains isolated from cloacae (group A), faeces (group B) and eggs (group C) of laying hens. Of these strains, 95% C. albicans and 23% C. catenulata strains displayed phospholipase and haemolytic activities. For C. albicans, the highest values of phospholipase (Pz = 0.62) and haemolytic activities (Hz = 0.49) were recorded among the strains from group C whilst for C. catenulata (Pz = 0.54; Hz = 0.49) among those from group A. High minimum inhibitory concentration (MIC) values for azoles and amphotericin B (AmB) were recorded irrespective of their sources in all C. albicans strains. A total of 22 C. albicans strains were multidrug resistant, displaying resistance to fluconazole, itraconazole (ITZ), voriconazole (VOR) and posaconazole (POS). All C. catenulata strains from group C were resistant to ITZ, POS, micafungin and anidulafungin and susceptible to AmB. In this study, C. albicans and C. catenulata isolated from the cloacae, faeces and eggs of laying hens produced phospholipase and haemolysin and might be multidrug resistant. In the environment (faeces) or in eggs, C. albicans and C. catenulata strains might acquire pathogenic virulence traits and/or show multidrug resistance profiles. Based on these results, breeding and handling of laying hens and/or eggs may have implications for human and animal health.

show abstract

“…-Амфотерицин B обладает более широким спектром противогрибковой активности по сравнению со многими другими антимикотическими средствами [31]. Однако его использование связано с многочисленными побочными эффектами, в том числе с почечной недостаточностью, что может привести к увеличению летальности пациентов.…”

Section: таблица 2 -этиотропная терапия кандидозной инфекцииunclassified

Invasive Mycoses in Intensive Care Units

Yakubtsevich¹

2020

Journal GSMU

View full text Add to dashboard Cite

Введение. Количество пациентов в отделениях реанимации, имеющих инвазивные микозы, в последние годы увеличилось. Это связано с внедрением инвазивных методов лечения, c иммуносупрессивной терапией, трансплантацией органов, а также c успехами в диагностике инфекций. Цель. Проведен анализ литературы с целью изучения современных подходов к этиотропной и патогенетической терапии инвазивных микозов среди пациентов реанимационных отделений. Материал и методы. Проанализирован 31 литературный источник. Результаты. Получены современные сведения о методах клинической и лабораторной диагностики и фармакологических агентах для лечения инвазивных микозов. Выводы. Один из приоритетов в борьбе с инвазивными микозами среди пациентов отделений интенсивной терапии-своевременная диагностика грибковой инфекции с профилактической терапией или таргетным воздействием на установленный источник инвазивного микоза.

show abstract

Systematic review on the first line treatment of amphotericin B in critically ill adults with candidemia or invasive candidiasis

Cited by 21 publications

References 46 publications

Predictive Nephrotoxicity Profiling of a Novel Antifungal Small Molecule in Comparison to Amphotericin B and Voriconazole

Predictive Nephrotoxicity Profiling of a Novel Antifungal Small Molecule in Comparison to Amphotericin B and Voriconazole

Virulence and in vitro antifungal susceptibility of Candida albicans and Candida catenulata from laying hens

Invasive Mycoses in Intensive Care Units

Contact Info

Product

Resources

About