Systematic review on respiratory syncytial virus epidemiology in adults and the elderly in Latin America

Ali, Abraham; Lopardo, Gustavo; Scarpellini, Bruno; Stein, Renato T.; Ribeiro, Diogo Farias

doi:10.1016/j.ijid.2019.10.025

Cited by 32 publications

(37 citation statements)

References 46 publications

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“…RSV-related morbidity seems to be underestimated in other age groups than the pediatric age group; however, awareness on the impact of RSV in adults is increasing, and estimates report at least 10% of pneumonia cases in adults to be RSV-related [ 6 , 7 ]. Efforts towards RSV prevention have resulted in passive immunoprophylaxis with monoclonal antibodies administered to high-risk patients, while clinical trials on possible vaccines are still being conducted with no product licensed to date [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Air Pollutants’ Concentrations Are Associated with Increased Number of RSV Hospitalizations in Polish Children

Wrotek

Badyda

Czechowski

et al. 2021

JCM

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Respiratory syncytial virus (RSV) contributes significantly to pediatric hospitalizations. An association between air pollution and an increased number of RSV cases has been suggested. We sought to evaluate the short-term impact of air pollutants on RSV hospitalizations in Polish children in the period 2010–2019. Daily concentrations of PM10 and PM2.5 (particulate matter with an aerodynamic diameter less than or equal to 10 μm and 2.5 μm, respectively) and nitrogen dioxide (NO2) were analyzed in general regression models (GRM) to establish their influence and full interaction scheme. Significant seasonal and annual periodicity among 53,221 hospitalizations was observed; finally, data from the 2012–2019 RSV high-risk seasons created models for seven agglomerations. The addition of PM2.5, PM10, and NO2 to the basic model for RSV seasonality explained 23% (4.9–31%, univariate model) to 31.4% (8.4–31%, multivariate model) of the variance in RSV hospitalizations. A 10 μg/m3 increase in PM2.5, PM10, and NO2 concentrations was associated with 0.134 (0.087–0.16), 0.097 (0.031–0.087), and 0.212 (0.04–0.29) average increases in hospitalizations, respectively. In the multivariate models, PM2.5, PM10, and NO2 alone, as well as PM2.5–NO2, PM2.5–PM10, and PM10–NO2 interactions, were associated with hospitalizations in some of the locations, while the metaregression showed statistically significant interactions between each of the pollutants, and between the pollutants and the year of the study. The inclusion of PM2.5, PM10, and NO2 in GRM explains a significant number of RSV hospitalizations. The pollutants act alone and interact together in a varied manner. Reducing air contamination might decrease the costs of hospital healthcare.

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Section: Introductionmentioning

confidence: 99%

Air Pollutants’ Concentrations Are Associated with Increased Number of RSV Hospitalizations in Polish Children

Wrotek

Badyda

Czechowski

et al. 2021

JCM

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“…RSV is commonly responsible for bronchiolitis in children, whereas in adults it is associated with influenza-like illness (ILI) or acute respiratory infections (ARIs) including pneumonia. RSV represents an underestimated clinical burden in adults, being the causative agent of 10.6%–13.5% of community pneumonia depending on whether patients are ambulatory or hospitalized [ 2 , 3 ]. Recent reports show that in hospitalized patients with RSV-ARI, intensive care unit (ICU) admission was necessary in 15%–16.8% of cases [ 4 , 5 ] and mortality ranged from 8% (in-hospital mortality) [ 5 ] to 11.9% at 60 days [ 6 ], which is comparable to that associated with influenza.…”

mentioning

confidence: 99%

Respiratory Syncytial Virus Infection: Its Propensity for Bacterial Coinfection and Related Mortality in Elderly Adults

Godefroy

Giraud-Gatineau

Jimeno

et al. 2020

Open Forum Infectious Diseases

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Respiratory syncytial virus (RSV) is an increasingly recognized cause of acute respiratory infection (ARI) in adults. We compared the crude in-hospital mortality of patients with RSV infection alone and with bacterial coinfection. Overall, 12,144 hospitalized patients with ARI were screened for RSV detection by PCR, between February 2014 and April 2019. In total, 701 (5.8%) had a positive RSV detection including 85 (12.1%) with bacterial coinfection. RSV-bacterial coinfection was associated with an increase in crude in-hospital mortality in patients over 65 years old (HR, 2.94 [95% CI, 1.30-6.60], P=.010). Optimized prevention and management strategies to reduce this burden are needed.

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“…At the same, as this new virus, is a concern for the world (at least it has already had a global economic impact), Latin America and even Colombia, among other regions and countries, Colombia faces an ongoing epidemic of dengue with over 130,000 cases, 1% of them severe, including more than 100 associated-deaths. When considering respiratory tract infections, multiple infectious agents are actively circulating, and will be increasing in the next few months in the region, including, those under surveillance, such as Influenza A (including AH1N1), Influenza B, human metapneumovirus, respiratory syncytial virus, adenovirus, parainfluenza 1, 2, 3 and 4, rhinovirus, bocavirus and enterovirus, among others [38][39][40] .…”

Section: Treatment and Preventionmentioning

confidence: 99%

A new emerging zoonotic virus of concern: the 2019 novel Coronavirus (COVID-19)

Millán-Oñate

Rodríguez‐Morales

Camacho-Moreno

et al. 2020

Infect

117

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We review here the origin, outbreak characteristics and main epidemiological features of the novel Coronavirus (2019nCoV) responsible of a new coronavirus disease . Rapid global health authorities' responses are now in course and international scientific collaboration is urgently need. Previous outbreaks experiences with similar viral agents have increased the capacity to containment and control of these recurrent health menaces. Un nuevo virus zoonótico emergente de preocupación: el Coronavirus novel 2019Resumen Revisamos aquí el origen, características del brote y la epidemiología del nuevo Coronavirus (2019nCoV) responsable de una nueva enfermedad por coronavirus . Una rápida respuesta de las autoridades de salud mundiales está en marcha y se ha hecho un llamado urgente para colaboración científica internacional. Las lecciones aprendidas de brotes previos con agentes virales similares han aumentado las capacidades para contener y controlar estas amenazas recurrentes a la salud global.

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Systematic review on respiratory syncytial virus epidemiology in adults and the elderly in Latin America

Cited by 32 publications

References 46 publications

Air Pollutants’ Concentrations Are Associated with Increased Number of RSV Hospitalizations in Polish Children

Air Pollutants’ Concentrations Are Associated with Increased Number of RSV Hospitalizations in Polish Children

Respiratory Syncytial Virus Infection: Its Propensity for Bacterial Coinfection and Related Mortality in Elderly Adults

A new emerging zoonotic virus of concern: the 2019 novel Coronavirus (COVID-19)

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