Systematic review of the oncological and functional outcomes of pelvic organ‐preserving radical cystectomy (<scp>RC</scp>) compared with standard <scp>RC</scp> in women who undergo curative surgery and orthotopic neobladder substitution for bladder cancer

Veskimäe, Erik; Neuzillet, Y.; Rouanne, Mathieu; MacLennan, Steven; Lam, Thomas; Yuan, Yuhong; Compérat, Éva; Cowan, Nigel C.; Gakis, Georgios; Heijden, Antoine G. van der; Ribal, María J.; Witjes, J. Alfred; Lebrét, Thierry

doi:10.1111/bju.13819

Cited by 74 publications

(74 citation statements)

References 39 publications

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“…Attempted bilateral or unilateral NS compared with no attempted NS positively influenced daytime continence in patients who underwent SC, whereas nighttime continence rates did not differ significantly among the three groups because of the similar continence rates between the bilateral and unilateral group. Our day-and nighttime continence rate of 87.5% is in line with the results from other genital organ-sparing case series, with daytime and nighttime continence rates of 64-100% and 50-89%, respectively [2].…”

Section: Discussionsupporting

confidence: 91%

“…Incomplete emptying or 'hypercontinence' is another complication of OBS in women, with reported rates of ISC ranging from 0% to 31% [2]. In the present study, the rate of ISC was the same in both groups and the small number of patients did not allow further analysis of the cause of incomplete emptying.…”

Section: Discussioncontrasting

confidence: 64%

“…Prolapse of the anterior vaginal wall was not a predominant finding in these patients, in contrast to observations made by others. Oncological outcome, especially local recurrence, is a major concern when considering ROSC, and data are still limited, as noted in a recent systematic review [2]. The results of the present study confirm that in well-selected cases the local recurrence rate is not higher after ROSC than after SC.…”

Section: Discussionsupporting

confidence: 62%

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Reproductive organ‐sparing cystectomy significantly improves continence in women after orthotopic bladder substitution without affecting oncological outcome

et al. 2018

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 64%

Section: Discussionsupporting

confidence: 62%

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Reproductive organ‐sparing cystectomy significantly improves continence in women after orthotopic bladder substitution without affecting oncological outcome

et al. 2018

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“…In this setting, when an ON is performed, the procedure can be associated with a considerable rate of voiding symptoms [4,5]. In addition, sexual dysfunction derived from such a highly demolitive surgical procedure is a key concern, especially in younger patients due to a significant impact on health-related quality of life (HRQoL) [6].…”

Section: Introductionmentioning

confidence: 99%

Sex-Sparing Robot-Assisted Radical Cystectomy with Intracorporeal Padua Ileal Neobladder in Female: Surgical Technique, Perioperative, Oncologic and Functional Outcomes

Tuderti¹,

Mastroianni

Flammia

et al. 2020

JCM

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Our aim was to illustrate our technique of sex-sparing (SS)-robot-assisted radical cystectomy (RARC) in female patients receiving an intracorporeal neobladder (iN). From January 2013 to June 2018, 11 female patients underwent SS-RARC-iN at a single tertiary referral center. Inclusion criteria were a cT ≤ 2 N0 M0 bladder tumor at baseline imaging (CT or MRI) and an absence of tumors in the bladder neck, trigone and urethra at TURB. Baseline, perioperative, and outcomes at one year were reported. The median operative time was 255 min and the median hospital stay was seven days. Low-grade Clavien complications occurred in four patients (36.3%), while high-grade complications were not observed in any. Seven patients (63.7%) had an organ-confined disease at the pathologic specimen; nodal involvement and positive surgical margins were not detected in any of the cases. At a median follow-up of 28 months (IQR 14–51), no patients developed new onset of chronic kidney disease stage 3b. After one year, daytime and nighttime continence rates were 90.9% and 86.4% respectively. Quality of life as well as physical and emotional functioning improved significantly over time (all p ≤ 0.04), while urinary symptoms and sexual function worsened at three months with a significant recovery taking place at one year (all p ≤ 0.04). Overall, 8 out of 11 patients (72.7%) were sexually active at the 12-month evaluation. In select female patients, SS-RARC-iN is an oncologically sound procedure associated with favorable perioperative and functional outcomes.

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“…При отсутствии противопоказаний стандартом лечения мышечно-инвазивного РМП, а также мышечно-неинвазивного РМП высокого риска (низкая степень дифференцировки, множественность опухоли, карцинома in situ) и рецидивного мышечно-неинвазивного РМП после трансуретральной резекции и внутрипузырной терапии является радикальная цистэктомия [8][9][10][11].…”

Section: Introductionunclassified

Choice of urine derivation method after radical cystectomy in the high anesthesiological risk group

Шкодкин¹,

Идашкин²

2020

Onkourologiâ

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Background. Radical cystectomy is the standard treatment for muscle-invasive bladder cancer. Muscle invasion can occur in 48 % of patients. Epidemiologically, the peak incidence of bladder cancer is observed in men at the seventh decade of life. At the time of diagnosis, many of these patients have serious comorbidity. The trauma of radical cystectomy in combination with comorbidity creates an insurmountable barrier to radical treatment in a large part of patients. Refusal to use intestinal segments for urine diversion dramatically reduces the invasiveness of the intervention. However, the implementation of bilateral ureterocutaneostomy is associated with a greater frequency of pyelonephritis due to the use of external stents and scarring of the ureterocutaneostomy. A transureteroureterostomy with a unilateral ureterocutaneostomy can be a definite alternative.Objective: to evaluate the effectiveness of cross ureteroureterostomy for urine derivation after radical cystectomy in patients with muscle-invasive bladder cancer and a high risk of perioperative complications.Materials and methods. The article analyzes 28 cystectomies for muscle-invasive bladder cancer in patients with severe concomitant pathology who underwent transureteroureterostomy with unilateral ureterocutaneostomy for urine derivation. Results. It was shown that this intervention does not have high morbidity, does not increase the incidence of early postoperative complications, and relieves patients from bilateral urostoma. Among late complications, inflammatory ones predominate due to obstruction of the external stent. The authors highlight the tactics and technical aspects of managing such patients with obstructive pyelonephritis and the experience of drainage-free management.Conclusion. Transureteroureterostomy with unilateral ureterocutaneostomy after cystectomy for muscle-invasive bladder cancer can be considered as the operation of choice in patients with a burdened comorbidity.

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Systematic review of the oncological and functional outcomes of pelvic organ‐preserving radical cystectomy (RC) compared with standard RC in women who undergo curative surgery and orthotopic neobladder substitution for bladder cancer

Cited by 74 publications

References 39 publications

Reproductive organ‐sparing cystectomy significantly improves continence in women after orthotopic bladder substitution without affecting oncological outcome

Reproductive organ‐sparing cystectomy significantly improves continence in women after orthotopic bladder substitution without affecting oncological outcome

Sex-Sparing Robot-Assisted Radical Cystectomy with Intracorporeal Padua Ileal Neobladder in Female: Surgical Technique, Perioperative, Oncologic and Functional Outcomes

Choice of urine derivation method after radical cystectomy in the high anesthesiological risk group

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