Systematic Review of the Influence of Antipsychotics on the Blood Oxygenation Level-Dependent Signal of Functional Magnetic Resonance Imaging

Röder, Christian; Dieleman, Sieds; Veen, Frederik M. van der; Linden, David

doi:10.2174/092986713804870891

Cited by 6 publications

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“…However, the potential effects of antipsychotics on the neural correlates of emotion processing are highly inconsistent. 42 , 67 – 70 Moreover, no group differences were detected in chlorpromazine-equivalent dose, and chlorpromazine equivalents did not correlate with brain activity. Further, the proportions of participants with SCZ receiving clozapine did not differ between groups, and clozapine had no significant influence on results.…”

Section: Discussionmentioning

confidence: 88%

Anterior cingulate hyperactivations during negative emotion processing among men with schizophrenia and a history of violent behavior

Tikàsz

Potvin

Lungu

et al. 2016

NDT

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BackgroundEvidence suggests a 2.1–4.6 times increase in the risk of violent behavior in schizophrenia compared to the general population. Current theories propose that the processing of negative emotions is defective in violent individuals and that dysfunctions within the neural circuits involved in emotion processing are implicated in violence. Although schizophrenia patients show enhanced sensitivity to negative stimuli, there are only few functional neuroimaging studies that have examined emotion processing among men with schizophrenia and a history of violence.ObjectiveThe present study aimed to identify the brain regions with greater neurofunctional alterations, as detected by functional magnetic resonance imaging during an emotion processing task, of men with schizophrenia who had engaged in violent behavior compared with those who had not.MethodsSixty men were studied; 20 with schizophrenia and a history of violence, 19 with schizophrenia and no violence, and 21 healthy men were scanned while viewing positive, negative, and neutral images.ResultsNegative images elicited hyperactivations in the anterior cingulate cortex (ACC), left and right lingual gyrus, and the left precentral gyrus in violent men with schizophrenia, compared to nonviolent men with schizophrenia and healthy men. Neutral images elicited hyperactivations in the right and left middle occipital gyrus, left lingual gyrus, and the left fusiform gyrus in violent men with schizophrenia, compared to the other two groups.DiscussionViolent men with schizophrenia displayed specific increases in ACC in response to negative images. Given the role of the ACC in information integration, these results indicate a specific dysfunction in the processing of negative emotions that may trigger violent behavior in men with schizophrenia.

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Section: Discussionmentioning

confidence: 88%

Anterior cingulate hyperactivations during negative emotion processing among men with schizophrenia and a history of violent behavior

Tikàsz

Potvin

Lungu

et al. 2016

NDT

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“…Second, antipsychotic medication may have influenced brain activation. However, several studies have shown that there is no common effect of antipsychotics on BOLD-signal ( Roder et al, 2013 ). Also, a high percentage of patients with schizophrenia used antipsychotic medication in this study, which makes this group of participants a good representation of the whole patient population.…”

Section: Discussionmentioning

confidence: 99%

Insight and emotion regulation in schizophrenia: A brain activation and functional connectivity study

Larabi

Meer

Pijnenborg

et al. 2018

NeuroImage: Clinical

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BackgroundInsight is impaired in the majority of schizophrenia patients. The exact neural correlates of impaired insight remain unclear. We assume that the ability to regulate emotions contributes to having good clinical insight, as patients should be able to regulate their emotional state in such a way that they can adapt adequately in order to cope with impaired functioning and negative stigma associated with a diagnosis of schizophrenia. Numerous studies have shown emotional dysregulation in schizophrenia. We investigated the association between insight and brain activation and connectivity during emotion regulation.MethodsBrain activation during emotion regulation was measured with functional MRI in 30 individuals with schizophrenia. Two emotion regulation strategies were examined: cognitive reappraisal and expressive suppression. Clinical insight was measured with the Schedule for the Assessment of Insight – Expanded, and cognitive insight was measured with the Beck Cognitive Insight Scale. Whole brain random effects multiple regression analyses were conducted to assess the relation between brain activation during emotion regulation and insight. Generalized psychophysiological interaction (gPPI) was used to investigate the relation between task-related connectivity and insight.ResultsNo significant associations were found between insight and neural correlates of cognitive reappraisal. For clinical insight and suppression, significant positive associations were found between symptom relabeling and activation in the left striatum, thalamus and insula, right insula and caudate, right pre- and postcentral gyrus, left superior occipital gyrus and cuneus and right middle and superior occipital gyrus and cuneus. Furthermore, reduced clinical insight was associated with more connectivity between midline medial frontal gyrus and right middle occipital gyrus. For cognitive insight and suppression, significant positive associations were found between self-reflectiveness and activation in pre- and postcentral gyrus and left middle cingulate gyrus.ConclusionsOur results suggest an association between the capacity to relabel symptoms and activation of brain systems involved in cognitive-emotional control and visual processing of negative stimuli. Furthermore, poorer self-reflectiveness may be associated with brain systems subserving control and execution.

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“…However, despite the known distribution of the receptors in the brain, the main places of action of dopaminergic drugs are not well characterized. A recent meta-analysis on pharmacological functional magnetic resonance imaging (phMRI) studies summarized the evidence for acute and chronic effects of antipsychotics (including QT) on the fMRI signal in cortical and also striatal and nigrostriatal regions (Roeder et al, 2013). For example, treatment with QT in healthy participants for 3 days increased functional connectivity of anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex with the amygdala during a virtual aggressive behavior task (Klasen et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Baseline Perfusion Alterations Due to Acute Application of Quetiapine and Pramipexole in Healthy Adults

Michels

Scherpiet

Staempfli³

et al. 2016

IJNPPY

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Background:The dopaminergic system is implicated in many mental processes and neuropsychiatric disorders. Pharmacologically, drugs with dopamine receptor antagonistic and agonistic effects are used, but their effects on functional brain metabolism are not well known.Methods:In this randomized crossover, placebo-controlled, and rater-blinded study, 25 healthy adults received an acute dose placebo substance (starch), quetiapine (dopamine receptor antagonist), or pramipexole (dopamine agonist of the nonergoline class) 1 hour before the experiment. Background-suppressed 2D pseudo-continuous arterial spin labeling was used to examine whole-brain baseline cerebral blood flow differences induced by the 3 substances.Results:We found that quetiapine reduced perfusion in the occipital (early visual areas) and bilateral cerebellar cortex relative to placebo. In contrast, quetiapine enhanced cerebral blood flow (relative to placebo) in the striatal system (putamen and caudate nucleus) but also in the supplementary motor area, insular-, prefrontal- as well as in the pre- and postcentral cortex. Pramipexole increased cerebral blood flow compared with placebo in the caudate nucleus, putamen, middle frontal, supplementary motor area, and brainstem (substantia nigra), but reduced cerebral blood flow in the posterior thalamus, cerebellum, and visual areas. Pramipexole administration resulted in stronger cerebral blood flow relative to quetiapine in the hypothalamus, cerebellum, and substantia nigra.Conclusions:Our results indicate that quetiapine and pramipexole differentially modulate regional baseline cerebral blood flow. Both substances act on the dopaminergic system, although they affect distinct regions. Quetiapine altered dopaminergic function in frontal, striatal, and motor regions. In contrast, pramipexole affected cerebral blood flow of the nigrostriatal (striatum and substantia nigra) dopaminergic, but less the fronto-insular system.

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Systematic Review of the Influence of Antipsychotics on the Blood Oxygenation Level-Dependent Signal of Functional Magnetic Resonance Imaging

Cited by 6 publications

References 0 publications

Anterior cingulate hyperactivations during negative emotion processing among men with schizophrenia and a history of violent behavior

Anterior cingulate hyperactivations during negative emotion processing among men with schizophrenia and a history of violent behavior

Insight and emotion regulation in schizophrenia: A brain activation and functional connectivity study

Baseline Perfusion Alterations Due to Acute Application of Quetiapine and Pramipexole in Healthy Adults

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