Systematic Review of the Comparative Effectiveness of Antiepileptic Drugs for Fibromyalgia

Long-term Safety of Gastroretentive Gabapentin in Postherpetic Neuralgia Patients

“…Although no other long-term safety data for gabapentin in patients with PHN were found, gabapentin has been administered for Z6 months to patients with epilepsy, fibromyalgia, and pain after spinal cord injury. 10,11,[22][23][24] Dizziness (25%), somnolence (19%), edema (16%), and headache (27%) were common AEs when gabapentin was administered for 6 months to patients with fibromyalgia. 11 In a 2-year interim report on the safety and efficacy of gabapentin in patients with refractory partial seizures, central nervous system AEs reported by >10% of patients included dizziness, somnolence, nystagmus, diplopia, tremor, and ataxia.…”

“…4,5 However, the immediate-release formulation of gabapentin is administered 3 times daily (tid) for PHN and its use in short-term trials (r8 wk) was associated with a high incidence of dizziness and somnolence. [6][7][8] Longer-term treatment (3.5 to Z12 mo) with gabapentin tid for chronic epilepsy, 9,10 with gabapentin tid and pregabalin for fibromyalgia, 11 and gabapentin enacarbil for restless legs syndrome, 12,13 cite dizziness, somnolence, edema, headache, and weight gain as common adverse events (AEs).…”

Pharmacological and Interventional Management of Pain After Whiplash Injury

“…16 Systematic reviews found them to be effective in fibromyalgia, but the effect size is likely modest. 20,28,34 The evidence supporting their use in low back pain is sparse. 8 Anticonvulsants act mainly at modulating sodium channels, calcium channels, and central glutamate mechanisms; the principal result is attenuation of excitability of nociceptive transmission.…”

Animal Models of Fibromyalgia

“…A recent systematic review of the effectiveness of antiepileptic drugs for fibromyalgia suggests that pregabalin is modestly effective, although long-term safety and efficacy results are unavailable (Siler et al, 2011). In intramuscular acidic saline injection model, pregabalin significantly recovers the lowered mechanical thresholds at a dose range of 10-100 mg/kg i.p.…”