Systematic review of site distribution of bone metastases in differentiated thyroid cancer

Osorio, Marcela; Moubayed, Sami P.; Su, Henry; Urken, Mark L.

doi:10.1002/hed.24655

Cited by 58 publications

(57 citation statements)

References 37 publications

(127 reference statements)

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“…Consistent with a recently published systematic review, the patients presented predominantly multiple bone involvement with spine preference [14]. In our cohort, 36% of the patients had BM as the presentation feature of thyroid cancer.…”

Section: Discussionsupporting

confidence: 73%

Bone Metastases from Thyroid Carcinoma of Follicular Origin: A Single Institutional Experience

Matta-Coelho

Simões‐Pereira

Vilar³

et al. 2018

Eur Thyroid J

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Background/Aims: Overall, 2–13% of patients with thyroid cancer develop bone metastases (BM). In addition to decreased survival, patients with BM may present skeletal-related events (SRE) that impair the quality of life. Our objectives were to characterize clinical features, treatment approaches, and outcomes of patients with thyroid cancer and BM. Material and Methods: We identified patients diagnosed with thyroid carcinoma of follicular origin and BM followed at the Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Lisbon, Portugal, from 1991 to 2017. SRE were defined as the need for bone irradiation, bone surgery, spinal cord compression, or pathologic fractures. Results: The final cohort consisted of 86 patients, with a median follow-up time of 54 months (IQR 22.8–82.8), mainly women (67.4%), and a median age of 64 years (IQR 53.6–71.2). BM was the initial presentation of thyroid cancer in 36.0% of the patients. Bone involvement was multiple in 59.3% of the cases. Papillary carcinoma was the most frequent histological type, present in 47.7% of the patients, of which 56.1% presented the follicular variant. SRE were found in 76.7% of the patients. The most frequent SRE was radiotherapy (66.3%). Treatment with bisphosphonates was initiated in 19.8% of the patients. The 5-year specific survival was 60%, whereas the 10-year specific survival decreased to 50%. There were no differences in 5- or 10-year specific survival regarding gender, the occurrence of SRE, or histological type. However, patients with initial radioiodine non-avid lesions had a lower 5- and 10-year specific survival (p = 0.002). Discussion: The high frequency of patients with SRE was notable. The follicular variant of papillary thyroid cancer was the variant most commonly associated with BM, reflecting a more similar behavior to follicular carcinoma than the classic variant.

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Section: Discussionsupporting

confidence: 73%

Bone Metastases from Thyroid Carcinoma of Follicular Origin: A Single Institutional Experience

Matta-Coelho

Simões‐Pereira

Vilar³

et al. 2018

Eur Thyroid J

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“…Bone metastases are more common in FTC than in PTC (55.5% versus 31.5%, respectively). Spinal (34.6%) and pelvic (25.5%) bones are the most frequently involved, followed by those of the chest (18.3%), extremities (10.2%), shoulder girdle (5.4%) and the craniomaxillofacial bones (5.4%) [74]. Brain, liver and skin involvement is less common.…”

Section: Management Of Advanced/metastatic Diseasementioning

confidence: 99%

Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

et al. 2019

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“…[8]. As far as bone metastasis is concerned, they have a favorite seat, the vertebrate, pelvis, ribs [11].…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Persistent or Recurrent Differentiated Thyroid Cancer

Hodé¹,

Aziz²,

Dedjan³

et al. 2020

OJEMD

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Introduction: The differentiated thyroid cancer has generally an excellent prognosis after the treatment. The aim of this study is to describe the characteristics of persistent or recurrent differentiated thyroid cancers. Patients/ Methods: It is about a descriptive and retrospective study conducted from 392 patients followed for differentiated thyroid cancer. The data concerning the persistent or recurrent differentiated thyroid cancer have been collected from 1986 to 2015 in endocrinology service in Ibn Rochd CHU. Results: In total, twenty-four patients have shown the relapse or the persistency of their tumor, corresponding to the prevalence of 6.12 percent. The papillary carcinoma was dominant in 79 percent of cases and the follicular carcinoma in 21 percent of cases. The metastases were cerebral (two cases), lung (3 cases), bones (3 cases, Figure 1), and lymph nodes (9 cases). In our series, eighteen cases of persistent differentiated thyroid cancer have been found against six cases of recurrent differentiated thyroid cancer. Two cases of death at least three years of followed in our series and concerned the two cases of cerebral metastasis. Conclusion: The persistent or recurrent differentiated thyroid cancer rate is low in our series. The discovery of the relapse t is late.

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Systematic review of site distribution of bone metastases in differentiated thyroid cancer

Abstract: The axial skeleton is the primary target of bone metastases in DTC. The relative distribution of bone metastases and red marrow content follow a similar rank. © 2017 Wiley Periodicals, Inc. Head Neck 39: 812-818, 2017.

Cited by 58 publications

References 37 publications

Bone Metastases from Thyroid Carcinoma of Follicular Origin: A Single Institutional Experience

Bone Metastases from Thyroid Carcinoma of Follicular Origin: A Single Institutional Experience

Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Characteristics of Persistent or Recurrent Differentiated Thyroid Cancer

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