Systematic review of recent advances in pharmacokinetics of four classical Chinese medicines used for the treatment of cerebrovascular disease

Zeng, Mingfei; Pan, Linmei; Qi, Shunmei; Yuntai, Cao; Zhu, Hua; Li-wei, Guo; Zhou, Jing

doi:10.1016/j.fitote.2013.04.006

Cited by 51 publications

(25 citation statements)

References 113 publications

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“…TMP, which has also been synthesized, exerts vasodilative, anticoagulant, anti‐inflammatory and positive inotropic effects. TMP has been widely used for the treatment of cardiovascular diseases (Guo, Liu, & Shi, 2016), due to its long history of safe usage, high efficacy, low expense, few adverse effects, and easy oral administration (Bai et al, 2014; Chen & Chen, 1992; Fu et al, 2012; Shaw, Chen, & Tsai, 2013; Wang et al, 2013; Zeng et al, 2013; Zhu, Wang, & Qin, 2009). In the present context, the beneficial effects of TMP have been shown in hypoxia‐induced PH, as a pulmonary vasodilator and by normalizing the right ventricular hypertrophy and muscularization of pulmonary arterioles (Cai & Barer, 1989).…”

Section: Introductionmentioning

confidence: 82%

Tetramethylpyrazine: A promising drug for the treatment of pulmonary hypertension

Chen

Yang

et al. 2020

British J Pharmacology

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Background and Purpose: Tetramethylpyrazine (TMP) was originally isolated from the traditional Chinese herb ligusticum and the fermented Japanese food natto and has since been synthesized. TMP has a long history of beneficial effects in the treatment of many cardiovascular diseases. Here we have evaluated the therapeutic effects of TMP on pulmonary hypertension (PH) in animal models and in patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH).Experimental Approach: Three well-defined models of PH -chronic hypoxia (10% O 2 )-induced PH (HPH), monocrotaline-induced PH (MCT-PH) and Sugen 5416/hypoxia-induced PH (SuHx-PH) -were used in Sprague-Dawley rats, and assessed by echocardiography, along with haemodynamic and histological techniques. Primary cultures of rat distal pulmonary arterial smooth muscle cells (PASMCs) were used to study intracellular calcium levels. Western blots and RT-qPCR assays were also used.In the clinical cohort, patients with PAH or CTEPH were recruited. The effects of TMP were evaluated in all systems.Key Results: TMP (100 mgÁkg −1 Áday −1 ) prevented rats from developing experimental PH and ameliorated three models of established PH: HPH, MCT-PH and SuHx-PH.The therapeutic effects of TMP were accompanied by inhibition of intracellular calcium homeostasis in PASMCs. In a small cohort of patients with PAH or CTEPH, oral Abbreviations: 2D, 2-dimensional; 6MWD, 6-min walking distance; Ccr, creatinine clearance; CTEPH, chronic thromboembolic pulmonary hypertension; EIP, End-inspiratory plateau pressure; FAC, Fractional area change; H&E, haematoxylin and eosin; HPH, hypoxia-induced pulmonary hypertension; HRR1, heart rate recovery at 1 min of rest; IPAH, idiopathic pulmonary arterial hypertension; KRBS, Krebs Ringer bicarbonate solution; LV, left ventricle; LVEF, left ventricular ejection fraction; LVFS, left ventricular fractional shortening; MCT, monocrotaline; mPAP, mean pulmonary arterial pressure; PA, pulmonary artery; PAD, pulmonary arterial diameter; PAH, pulmonary arterial hypertension; PAP, pulmonary arterial pressure; PASMC, pulmonary arterial smooth muscle cells; PAT, pulmonary arterial acceleration time; PET, pulmonary arterial ejection time; PH, pulmonary hypertension; PVR, pulmonary vascular resistance; RAD, right atrium diameter; RHC, right heart catheterization; ROCC, receptor-operated Ca 2+ channels; ROCE, receptor-operated Ca 2+ entry; RV, right ventricle; RVEDD, Right ventricular end diastolic diameter; RVEDWT, right ventricular end-diastolic free-wall thickness; RVSP, right ventricular systolic pressure; S, septum; SOCC, store-operated Ca 2+ channels; SOCE, store-operated Ca 2+ entry; SuHx-PH, Sugen/hypoxia-induced pulmonary hypertension; TAPSE, tricuspid annular plane systolic excursion; TMP, tetramethylpyrazine; VDCC, voltage-dependent Ca 2+ channels. administration of TMP (100 mg, t.i.d. for 16 weeks) increased the 6-min walk distance and improved the 1-min heart rate recovery.Conclusion and Implications: Our results s...

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Section: Introductionmentioning

confidence: 82%

Tetramethylpyrazine: A promising drug for the treatment of pulmonary hypertension

Chen

Yang

et al. 2020

British J Pharmacology

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“…Salvia miltiorrhiza Bge., called ‘Danshen’ in China, is a well‐known TCM, which was first documented in Shen Nong Ben Cao Jing (Liang et al, ; Shu et al, ). It has been widely used in the clinic for the treatment of various diseases, such as cardiovascular disease (Chen, Li, & Tian, ), cerebrovascular disease (Zeng et al, ), liver fibrosis (Parajuli et al, ) and cancer (Shen, Lou, Zhang, Xu, & Zhang, ). The active components contained in S. miltiorrhiza Bge.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the chromatographic fingerprint, multicomponent quantitation and antioxidant activity of Salvia miltiorrhiza Bge. between sweating and nonsweating

Fan

Wang

et al. 2018

Biomedical Chromatography

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Salvia miltiorrhiza Bge. is a traditional Chinese medicine applied in the treatment of various diseases in clinical practice. In the course of its processing, S. miltiorrhiza Bge. is usually processed by sweating. This study employed 10-component contents determination coupled with high-performance liquid chromatography (HPLC) fingerprint and antioxidant activity to investigate the effect of sweating on S. miltiorrhiza Bge. so as to evaluate the quality of S. miltiorrhiza Bge. The HPLC method was performed using C and 0.05% phosphoric acid aqueous solution-acetonitrile with a gradient elution system. It was validated for linearity, precision, repeatability, stability and recovery. Similarity analysis, principal components analysis and antioxidant activity assays were used to compare sweated S. miltiorrhiza Bge. (SSM) and nonsweated S. miltiorrhiza Bge. (NSSM). SSM and NSSM showed good similarities in HPLC fingerprint (>0.9), but principal components analysis could classify the HPLC fingerprint and 10-component quantitation analysis. Meanwhile, the antioxidant activity of SSM was significantly higher than that of NSSM (p < 0.01). The results of this study indicated that sweating could alter the content of chemical constituents in S. miltiorrhiza Bge., and could also improve its antioxidant activity. In addition, the method not only affords a viable strategy for comparing SSM and NSSM and assessing the quality of S. miltiorrhiza Bge., but also provides a reference for other herbal medicine that suffers from sweating.

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“…Over the past few years, various pharmacological properties found in S. miltiorrhiza are effective with cardio-cerebrovascular conditions (Cheng, 2007;Zeng et al, 2013), as well as anti-oxidative (Bai and Li, 2016), neuroprotective (Hügel and Jackson, 2014), anti-inflammatory (Stumpf et al, 2013;Chen et al, 2016), antineoplastic Gao et al, 2015) and renoprotective effects (Guan et al, 2015;Jiang et al, 2016). Recent evidence demonstrates that the aqueous extracts of S. miltiorrhiza ameliorate renal dysfunction and attenuate the structural manifestations of renal glomerulus and tubule in DN rats (Lee et al, 2011;Yin et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Salvia miltiorrhizaLipophilic Fraction Attenuates Oxidative Stress in Diabetic Nephropathy through Activation of Nuclear Factor Erythroid 2-Related Factor 2

Marikar

et al. 2017

Am. J. Chin. Med.

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Diabetic nephropathy (DN) is a common cause of chronic kidney disease and end-stage renal disease, which can be triggered by oxidative stress. In this study, we investigated the renoprotective effect of the ethyl acetate extract of Salvia miltiorrhiza (EASM) on DN and examined the underlying molecular mechanism. We observed that EASM treatment attenuated metabolic abnormalities associated with hyperglycemic conditions in the experimental DN model. In streptozotocin (STZ)-induced mice, EASM treatment reduced albuminuria, improved renal function and alleviated the pathological alterations within the glomerulus. To mimic the hyperglycemic conditions in DN patients, we used high glucose (25 mmol/L) media to stimulate mouse mesangial cells (MMCs), and EASM inhibited high glucose-induced reactive oxygen species. We also observed that EASM enhanced the expression of nuclear factor erythroid-2-related factor 2 (Nrf2), which mediated the antioxidant response, and its downstream gene heme oxygenase-1 (HO-1) and NAD(P)H quinone dehydrogenase 1 (NQO1) with concomitant decrease of expression of kelch-like ECH-associated protein 1 (keap1) both in vitro and in vivo. Taken together, these results suggest that EASM alleviates the progression of DN and this might be associated with activation of Nrf2.

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Systematic review of recent advances in pharmacokinetics of four classical Chinese medicines used for the treatment of cerebrovascular disease

Cited by 51 publications

References 113 publications

Tetramethylpyrazine: A promising drug for the treatment of pulmonary hypertension

Tetramethylpyrazine: A promising drug for the treatment of pulmonary hypertension

Comparison of the chromatographic fingerprint, multicomponent quantitation and antioxidant activity of Salvia miltiorrhiza Bge. between sweating and nonsweating

Salvia miltiorrhizaLipophilic Fraction Attenuates Oxidative Stress in Diabetic Nephropathy through Activation of Nuclear Factor Erythroid 2-Related Factor 2

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