Systematic review of high-intensity focused ultrasound ablation in the treatment of breast cancer

Peek, Mirjam; Ahmed, Muneer; Napoli, Alessandro; Haken, Bennie ten; McWilliams, S.; Usiskin, Sasha I; Pinder, Sarah; Hemelrijck, Mieke Van; Douek, Michael

doi:10.1002/bjs.9793

Cited by 77 publications

(44 citation statements)

References 21 publications

(258 reference statements)

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“…In the previous studies, coagulation necrosis [26], skin burns [27–31] as well as pectoralis major injury [31] are common complications detected after IRE simulation. No obvious skin burns were found in group A or group B after the operation in our study.…”

Section: Discussionmentioning

confidence: 99%

Breast tissue ablation with irreversible electroporation in rabbits: A safety and feasibility study

et al. 2017

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Background and aimIrreversible electroporation (IRE) was confirmed to control several solid tumors effectively in vivo. Our preclinical study aimed to assess the feasibility and safety of IRE in the breast of rabbit.MethodsThirty New Zealand white rabbits were randomly divided into 3 groups of 10 rabbits (control group, IRE group A, and B). Two mono-electrode needles were inserted into the breast tissue by percutaneous puncture. Electrocardiogram and vital signs were monitored before, during, and after ablation. Histopathology, immunohistochemistry, and transmission electron microscopy were examined at 0 hours, 12 hours, 24 hours, 4 days, 7 days, 14 days, and 28 days after ablation.ResultsAll the rabbits survived the procedure with no significant adverse effects. Intra-operative ventricular arrhythmias occurred in 1 rabbit from IRE group B and was immediately relieved after ablation. Reversible subcutaneous hemorrhage was observed in 8 rabbits from IRE group A and 7 rabbits from IRE group B. No skin was burnt, however, pectoralis major muscle injuries were found in all rabbits. Histopathological and ultrastructural examination revealed the coexistence of cell necrosis and apoptosis. HE, TUNEL, and Masson staining revealed breast tissue injury and the recovery of damage by fibrous tissue and granulation tissue. Notably, the structures of mammary gland lobules and interstitial components of the breasts were well preserved.ConclusionsOur study suggests that IRE destroys breast cancer while effectively preserving the skin, the structure of mammary gland lobules, and interstitial components. IRE may be a promising technique to locally control breast cancer and to maintain the esthetic of the breast.

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Section: Discussionmentioning

confidence: 99%

Breast tissue ablation with irreversible electroporation in rabbits: A safety and feasibility study

et al. 2017

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“…148 During HIFU treatment, an ultrasound beam generated by a piezoelectric ultrasound transducer propagates through tissue as a high-frequency pressure wave. 147 The energy-absorption characteristics of the tissue enable it to absorb a portion of the acoustic energy transported by the ultrasonic field, and this acoustic energy is converted into heat.…”

Section: High-intensity Focused Ultrasoundmentioning

confidence: 99%

Surgical treatment of nonpalpable primary invasive and in situ breast cancer

et al. 2015

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Breast cancer is the most-common cancer among women worldwide, and over one-third of all cases diagnosed annually are nonpalpable at diagnosis. The increasingly widespread implementation of breast-screening programmes, combined with the use of advanced imaging modalities, such as magnetic resonance imaging (MRI), will further increase the numbers of patients diagnosed with this disease. The current standard management for nonpalpable breast cancer is localized surgical excision combined with axillary staging, using sentinel-lymph-node biopsy in the clinically and radiologically normal axilla. Wire-guided localization (WGL) during mammography is a method that was developed over 40 years ago to enable lesion localization preoperatively; this technique became the standard of care in the absence of a better alternative. Over the past 20 years, however, other technologies have been developed as alternatives to WGL in order to overcome the technical and outcome-related limitations of this technique. This Review discusses the techniques available for the surgical management of nonpalpable breast cancer; we describe their advantages and disadvantages, and highlight future directions for the development of new technologies.

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“…We specifically explore the implementation of magnetic resonance-guided focused ultrasound (MRgFUS) ablation combined with TLR agonists and checkpoint inhibitors. The clinical indications for MRgFUS have exploded in recent years due to the opportunity to precisely deliver treatment to select regions of interest (17)(18)(19); thermal ablation of large regions is clinically targeted by scanning the ultrasound focus in a circular pattern or creating a grid pattern of overlapping ablation points (20,21). Treatment is monitored by MRI and thermometry, which are used to direct the ultrasound beam and generate maps of the temperature and thermal dose in real-time (22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

Priming is key to effective incorporation of image-guided thermal ablation into immunotherapy protocols

Silvestrini¹,

Ingham²,

Mahakian³

et al. 2017

JCI Insight

111

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Systematic review of high-intensity focused ultrasound ablation in the treatment of breast cancer

Cited by 77 publications

References 21 publications

Breast tissue ablation with irreversible electroporation in rabbits: A safety and feasibility study

Breast tissue ablation with irreversible electroporation in rabbits: A safety and feasibility study

Surgical treatment of nonpalpable primary invasive and in situ breast cancer

Priming is key to effective incorporation of image-guided thermal ablation into immunotherapy protocols

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