Systematic review of finasteride effect in women with hirsutism

Júnior, José Maria Soares; Guimarães, Daniela de Oliveira; Simões, Ricardo; Veiga, Eduardo Carvalho de Arruda; Roa, Cristiane Lima; Sorpreso, Isabel Cristina Espósito; Baracat, Maria Cândida Pinheiro; Baracat, Edmund Chada

doi:10.1590/1806-9282.20210248

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…The excess hair growth is often course, like sexual or secondary hair such as those seen in male growth patterns (80,81). While often presenting as primary idiopathic Hirsutism, numerous aetiologies can lead to excess androgen production and therefore the development of hirsutism, including polycystic ovarian syndrome, acromegaly, prolactinemia or thyroid disfunction (82).…”

Section: Other Non-urological Indications For 5-arismentioning

confidence: 99%

5-alpha reductase inhibitors use in prostatic disease and beyond

Chislett¹,

Chen²,

Perera³

et al. 2023

Transl Androl Urol

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in use today (1,2). Their effect relies on the inhibition of the 5-alpha reductase (5α-reductase) enzyme which aids in the conversion of testosterone to dihydrotestosterone (DHT) (3).Since its introduction, the clinical indication for 5-ARIs has grown from BPH to include androgenetic alopecia (AGA) and hirsutism (1). As more pathological processes are identified as being mediated by DHT, the clinical

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Section: Other Non-urological Indications For 5-arismentioning

confidence: 99%

5-alpha reductase inhibitors use in prostatic disease and beyond

Chislett¹,

Chen²,

Perera³

et al. 2023

Transl Androl Urol

View full text Add to dashboard Cite

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β-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

Xu,

Dai,

et al. 2024

Molecules

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β-Nicotinamide mononucleotide (NMN) has shown promising effects on intestinal health, and it is extensively applied as an anti-aging and Alzheimer’s disease therapeutic, due to its medicinal properties. The effects of NMN on the growth of mouse hair were observed after hair removal. The results indicated that NMN can reverse the state of hair follicle atrophy, hair thinning, and hair sparsity induced by dihydrotestosterone (DHT), compared to that of minoxidil. In addition, the action mechanisms of NMN promoting hair growth in cultured human dermal papilla cells (HDPCs) treated with DHT were investigated in detail. The incubation of HDPCs with DHT led to a decrease in cell viability and the release of inflammatory mediators, including interleukin-6 (IL-6), interleukin-1Beta (IL-1β) and tumor necrosis factor Alpha (TNF-α). It was found that NMN can significantly lower the release of inflammatory factors induced by DHT in HDPCs. HDPCs cells are protected from oxidative stress damage by NMN, which inhibits the NF-κB p65 inflammatory signaling pathway. Moreover, the levels of androgen receptor (AR), dickkopf-1 (DKK-1), and β-catenin in the HDPCs were assessed using PCR, indicating that NMN can significantly enhance the expression of VEGF, reduced IL-6 levels and suppress the expression of AR and DKK-1, and notably increase β-catenin expression in DHT-induced HDPCs.

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A Narrative Review of Herbal Remedies for Managing Hirsutism

Ghanbarian,

Ranjbai,

Babaeian

et al. 2024

International Journal of Preventive Medicine

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Hirsutism is a condition that can have medical, social, and psychological implications, affecting 5% to 10% of women worldwide. Management options include cosmetic procedures and pharmacological interventions. However, medications used to treat hirsutism can have side effects, ranging from mild symptoms like nausea and headaches to more serious complications such as vascular clots, heart attacks, hepatotoxicity, osteoporosis, and effeminization of a male fetus. Therefore, this study aims to investigate the potential benefits of medicinal plants on hirsutism as a complementary approach, specifically whether they can be used as adjuvants to cosmetic procedures. Databases including Google Scholar, PubMed, Scopus, Embase, ISI, SID, and Mag Iran have been checked with related keywords from 2000 to 2023. Moreover, related articles were isolated. In total, ten trials were identified in the search. The results suggested that various herbs, including fennel, licorice, spearmint, saw palmetto, green tea, combination of Zingiber and neem, curcumin, and teupolioside have the potential as herbal remedies for hirsutism. However, further extensive well-designed studies involving a large sample size on the most promising herbs are necessary to determine their efficacy.

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Systematic review of finasteride effect in women with hirsutism

Cited by 3 publications

References 24 publications

5-alpha reductase inhibitors use in prostatic disease and beyond

5-alpha reductase inhibitors use in prostatic disease and beyond

β-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

A Narrative Review of Herbal Remedies for Managing Hirsutism

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