Systematic Review of Anti-inflammatory Agents from Aspergillus Species

Ferreira, Miller Santos; Katchborian-Neto, Albert; Cruz, Jonas Carneiro; Nicácio, Karen de Jesus; Dias, Danielle Ferreira; Chagas‐Paula, Daniela Aparecida; Soares, Marisi G.

doi:10.1007/s43450-021-00166-1

Cited by 2 publications

(1 citation statement)

References 55 publications

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“…The polyketides isolated from A. rugulosa exhibited anti-inflammatory effects better than the positive control [57]. Similarly, a review of Aspergillus genus metabolites revealed that a rich source of anti-inflammatory metabolites are synthesized by Aspergillus genus species such as, polyketides, terpenoids, butenolides, and alkaloids [58]. This study will help expand the database of Aspergillus anti-inflammatory metabolites and increase knowledge of the mechanism of action of these fungal metabolites.…”

Section: Table 5 Anti-inflammatory Activity Of Ethyl Acetate Extract ...mentioning

confidence: 71%

Insights into metabolic and pharmacological profiling of Aspergillus ficuum through bioinformatics and experimental techniques

et al. 2022

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Background Recently, numerous novel bioactive fungal metabolites have been identified that possess broad therapeutic activities including anti-inflammatory, antibiotic, antioxidant, and antitumor. The fungal mycochemicals as well as extracts have increased the interest of the scientific community in drug discovery research through a combination approach such as, molecular metabolic, pharmacological and computational techniques. Therefore, the natural fungus Aspergillus ficuum (A. ficuum) (FCBP-DNA-1266) was selected for metabolic and pharmacological profiling in this study. Results The metabolic profile of A. ficuum was explored for the first time and revealed the presence of bioactive compounds such as choline sulfate, noruron, hydroxyvittatine, aurasperone D, cetrimonium, kurilensoside, heneicosane, nonadecane and eicosane. Similarly, a pharmacological screen of A. ficuum was performed for the first time in in vivo and in vitro models. Interestingly, both the ethyl acetate and n-hexane fractions of A. ficuum were found to be more active against Bacillus subtilis among five tested bacteria with their zone of inhibition (ZOI) values of 21.00 mm ±1.00 and 23.00 mm ±1.00, at a concentration of 150 μgmL-1 respectively. Similarly, a significant decrease (P<0.001) and (P<0.01) in paw edema was observed in A. ficuum-treated animals at doses of 50 and 150 mgkg-1, respectively, reflecting its potent anti-inflammatory effect. Furthermore, the docking results supported the antibacterial and anti-inflammatory effects of A. ficuum. In addition, the crude extract demonstrated no acute toxicity and the highest percent radical scavenging was recorded for both n-hexane and ethyl acetate extracts. Conclusion The metabolic profile of A. ficuum indicated the presence of biological relevant compounds. A. ficuum extract exhibited potent antibacterial and anti-inflammatory effects supported by docking results. Furthermore, A. ficuum extract demonstrated the highest percentage of radical scavenging activity along with no acute toxicity.

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Section: Table 5 Anti-inflammatory Activity Of Ethyl Acetate Extract ...mentioning

confidence: 71%

Insights into metabolic and pharmacological profiling of Aspergillus ficuum through bioinformatics and experimental techniques

et al. 2022

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Phytochemical investigation of Nigrospora zimmermanii isolated from Poincianella pluviosa (Sibipiruna): metabolites characterisation and screening for anti-inflammatory activity

Ferreira,

Katchborian-Neto,

Nicácio

et al. 2024

Natural Product Research

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Endophytic fungi residing symbiotically in plant tissues are promising sources of bioactive natural products. This study explored the anti-inflammatory potential of an endophytic fungus isolated from the Brazilian medicinal plant Poincianella pluviosa (Sibipiruna). The extract from the endophyte FPD13 exhibited potential ex vivo anti-inflammatory effects by inhibiting prostaglandin E2 (PGE2) release by 75.22%. Phytochemical analysis using High-Performance Liquid Chromatography (HPLC), Nuclear Magnetic Resonance (NMR), and Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) enabled the isolation and identification of three compounds, including the macrolide Nigrosporolide, the phenyl-propanol Tyrosol, and the terpene Decarestrictine A. Morphological characteristics and Internal Transcribed Spacers region (ITS) sequencing classified fungus FPD13 as Nigrospora zimmermanii. The results reveal the anti-inflammatory potential and chemical diversity of P. pluviosa endophytes, warranting further investigation into the bioactivity and structure elucidation of their bioactive metabolites.

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Systematic Review of Anti-inflammatory Agents from Aspergillus Species

Cited by 2 publications

References 55 publications

Insights into metabolic and pharmacological profiling of Aspergillus ficuum through bioinformatics and experimental techniques

Insights into metabolic and pharmacological profiling of Aspergillus ficuum through bioinformatics and experimental techniques

Phytochemical investigation of Nigrospora zimmermanii isolated from Poincianella pluviosa (Sibipiruna): metabolites characterisation and screening for anti-inflammatory activity

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