Systematic review/Meta-analysis Interleukin-1B-31T/C promoter polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis

Xiao, Min; Guo, Lingli; Wang, Tao; Zhu, Tao; Jia, Liting; Chen, Lei; Wen, Funqiang

doi:10.5114/aoms.2014.43737

Cited by 9 publications

(5 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present results suggest that miR-21 was upregulated in DLBCL tissues and its expression in non-GCB tissues was higher when compared with GCB tissues. These findings were consistent with the results from previous studies (24,25).…”

Section: Discussionsupporting

confidence: 83%

MicroRNA‑21 regulates the viability and apoptosis of diffuse large B‑cell lymphoma cells by upregulating B cell lymphoma‑2

Liu

Ruan

2017

Exp Ther Med

View full text Add to dashboard Cite

Abstract. Diffuse large B-cell lymphoma (DLBCL), one of the most frequently diagnosed non-Hodgkin lymphoma (NHL), is partly attributed to hereditary factors. is an oncogenic substance that induces NHL and primarily targets tumor-suppressive molecules, such as B cell lymphoma-2 (Bcl-2). The present study explored whether Bcl-2, targeted by miR-21, would affect the development of NHL. Specimens were harvested from 55 patients with DLBCL who had undergone surgical treatment. Expression levels of miR-21 and Bcl-2 were evaluated through reverse transcription-quantitative polymerase chain reaction, immunohistochemistry and western blotting. Luciferase-reporter assays were performed to investigate the potential association between miR-21 and Bcl-2. MTT assays, flow cytometric analysis and caspase-3 activity assays were used to evaluate cell viability and apoptosis of DLBCL cells, respectively. Furthermore, statistical analysis was conducted using SPSS 19.0 software and the expression levels of miR-21 and Bcl-2 within DLBCL tissues were significantly upregulated when compared to those in normal tissues (P<0.01). As predicted by TargetScan, perfect base pairing was observed between the seed sequence of mature miR-21 and the 3' untranslated region of Bcl-2 mRNA. Dual luciferase reporter gene assays also revealed that miR-21 significantly facilitated the luciferase activity of Bcl-2 wild-type, with 61% upregulation (P<0.01) observed. MTT assays demonstrated that the viability of OCI-LY3 cells was decreased when cells were transfected with miR-21 inhibitor or Bcl-2 small interfering RNA and compared with those of control and negative control groups (all P<0.05). The apoptosis rate and caspase-3 activity level of the miR-21 group were 2.73±0.48 and 0.47±0.05, respectively, which were both significantly different from the groups with lower levels of miR-21 expression levels (all P<0.01). Since miR-21 may contribute to increased viability and decreased apoptosis of DLBCL cells through targeting Bcl-2, both Bcl-2 and miR-21 are likely to serve as effective targets for developing novel DLBCL treatments in the future.

show abstract

Section: Discussionsupporting

confidence: 83%

MicroRNA‑21 regulates the viability and apoptosis of diffuse large B‑cell lymphoma cells by upregulating B cell lymphoma‑2

Liu

Ruan

2017

Exp Ther Med

View full text Add to dashboard Cite

show abstract

“…The interleukin-1 gene cluster has been mapped to the long arm of chromosome 2 and consists of three genes, IL-1α, IL-1β and IL-1 receptor antagonist genes, encoding IL-1α, IL-1β and IL-1 receptor antagonist proteins, respectively [ 42 ]. There are studies suggesting that some kinds of polymorphisms in the IL1B gene are associated with an increased risk of diseases such as chronic obstructive pulmonary disease [ 43 ] or chronic periodontitis [ 44 ]. In the experimental and clinical research, it has been demonstrated that administration of a receptor antagonist or immunoglobulins against IL-1β prevents the increase in IL-6 and TNF-α in inflammation, as well as decreasing the severity of inflammation [ 40 , 45 – 48 ].…”

Section: Discussionmentioning

confidence: 99%

Pretreatment with obestatin inhibits the development of acetic acid-induced colitis in rats

Matuszyk¹,

Ceranowicz²,

Warzecha³

et al. 2016

aoms

View full text Add to dashboard Cite

IntroductionObestatin is a 23-amino acid peptide derived from proghrelin, a common prohormone for ghrelin and obestatin. Previous studies have shown that obestatin exhibits some protective and therapeutic effects in the pancreas and stomach. The aim of this study was to examine the effect of pretreatment with obestatin on the development of acetic acid-induced colitis.Material and methodsStudies were performed on Wistar rats. Before induction of colitis, rats were treated intraperitoneally with saline or obestatin, administered twice at a dose of 4, 8 or 16 nmol/kg/dose. The first dose of saline or obestatin was administered 8 h before the induction of colitis, the second one 7 h after the first dose. Colitis was induced by enema with 1 ml of 4% acetic acid solution. The severity of colitis was assessed 1 or 24 h after administration of enema.ResultsPretreatment with obestatin administered at a dose of 8 or 16 nmol/kg/dose significantly reduced the area of mucosal damage evoked by enema with acetic acid (p < 0.05). This effect was accompanied by an improvement of mucosal blood flow and DNA synthesis in the colon. Moreover, obestatin administered at a dose of 8 or 16 nmol/kg/dose significantly reduced mucosal concentration of IL-1β and activity of myeloperoxidase (p < 0.05).ConclusionsPretreatment with obestatin exhibited a protective effect in the colon, leading to a reduction of colonic damage in acetic acid-induced colitis. This effect was associated with an improvement of mucosal blood flow, an increase in mucosal cell proliferation, and a decrease in local inflammation.

show abstract

“…Nevertheless, the association between this polymorphism and prostate cancer risk remains conflicting. Meta-analysis is used to combine the previous results to yield the most reliable and comprehensive conclusion because the individual research was too minor to achieve a valid conclusion [ 47 , 48 ]. In this article, novel case-control studies from the last years were enrolled and a meta-analysis containing 9,720 prostate cancer patients and 9,710 controls from 25 independent case-control studies was performed.…”

Section: Discussionmentioning

confidence: 99%

Updated analysis of vitamin D receptor gene FokI polymorphism and prostate cancer susceptibility

Mi¹,

Chen²,

Chen³

et al. 2017

aoms

View full text Add to dashboard Cite

IntroductionPolymorphisms of the vitamin D receptor (VDR) gene have been investigated in various case-control studies to evaluate prostate cancer susceptibility; however, published data on the association between vitamin D receptor gene FokI polymorphism and prostate cancer risk are inconclusive.Material and methodsTo assess the impact of vitamin D receptor gene FokI polymorphism, we performed a meta-analysis of eligible studies including 9,720 patients and 9,710 control subjects.ResultsThe overall results indicated no obvious association of this variant on prostate cancer risk. However, in subgroup analysis by ethnicity, positive associations existed in Caucasian descendents for allelic contrast (OR = 1.03, 95% CI: 1.00–1.06, pheterogeneity = 0.552, p = 0.026) and the dominant genetic model (OR = 1.03, 95% CI: 1.00–1.05, pheterogeneity = 0.856, p = 0.032). In the subgroup analysis by tumor stage, there was a significant association between this variant and advanced prostate cancer under the recessive genetic model (OR = 1.15, 95% CI: 1.01–1.32, pheterogeneity = 0.469, p = 0.032). In the subgroup analysis by source of control, association of the VDR FokI polymorphism and prostate cancer susceptibility was also found in population-based studies under homozygote comparison and the recessive genetic model.ConclusionsThe VDR FokI polymorphism may contribute to the risk of developing prostate cancer in Caucasian and population-based studies. Further large, well-designed studies are warranted to confirm this conclusion in more detail.

show abstract

Systematic review/Meta-analysis Interleukin-1B-31T/C promoter polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis

Cited by 9 publications

References 10 publications

MicroRNA‑21 regulates the viability and apoptosis of diffuse large B‑cell lymphoma cells by upregulating B cell lymphoma‑2

MicroRNA‑21 regulates the viability and apoptosis of diffuse large B‑cell lymphoma cells by upregulating B cell lymphoma‑2

Pretreatment with obestatin inhibits the development of acetic acid-induced colitis in rats

Updated analysis of vitamin D receptor gene FokI polymorphism and prostate cancer susceptibility

Contact Info

Product

Resources

About