Systematic review and meta-analysis: Prevalence of incidentally detected pancreatic cystic lesions in asymptomatic individuals

Zerboni, Giulia; Signoretti, Marianna; Crippa, Stefano; Falconi, Massimo; Arcidiacono, Paolo Giorgio; Capurso, Gabriele

doi:10.1016/j.pan.2018.11.014

Cited by 148 publications

(117 citation statements)

References 42 publications

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“…A recent meta‐analysis reported that the pooled prevalence of incidental PCLs was 8% and four times higher in studies conducted in the USA than in Asia . The prevalence of PCLs in our study group was 1.0%, which is lower than that reported in previous studies (1.9–2.1%) .…”

Section: Discussioncontrasting

confidence: 84%

Progression of pancreatic cystic lesions without any risk features is associated with initial cyst size and obesity

Park

Lee

Park³

et al. 2019

J of Gastro and Hepatol

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Background and Aim:The clinical significance of incidental pancreatic cystic lesions (PCLs) remains unclear in those that are not accompanied by worrisome features or high-risk stigmata. We aimed to investigate the natural course of PCLs without any risk features and examine the clinical factors associated with their progression. Methods: We conducted a retrospective cohort study of 427 patients with PCLs, which were incidentally detected by computed tomography between January 2003 and December 2012. Progression of PCLs without any risk features and the clinical factors associated with their progression were investigated. The length of time to significant growth was also evaluated. Results: Ninety-four (22.0%) of the 427 patients had asymptomatic PCLs that showed significant growth after a median surveillance period of 5.3 years; approximately 27.7% of the patients showed significant size changes in the first 5 years, while the remaining 72.3% showed significant changes after 5 years. The cumulative rate of patients with significant growth was associated with initial cyst size and high body mass index. In the growth group, additional treatments were required for 12 patients, one of whom developed malignancy. Four patients in the stable group underwent additional treatment and showed no malignant change. Conclusions: One-fifth of the asymptomatic PCLs significantly increased in size after a long-term follow-up period, which was associated with initial cyst size and obesity. The size of PCLs mostly increased after 5 years; although the malignancy risk of PCLs was low, it was still a concern.

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Section: Discussioncontrasting

confidence: 84%

Progression of pancreatic cystic lesions without any risk features is associated with initial cyst size and obesity

Park

Lee

Park³

et al. 2019

J of Gastro and Hepatol

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“…Therefore, we have reasons to believe that the prevalence of PCLs varies in different races. The Asian population has a lower prevalence of PCLs than the Caucasian population . However, the Asian population also consists of many races, with the Chinese population being one of them.…”

Section: Discussionmentioning

confidence: 99%

“…The Asian population has a lower prevalence of PCLs than the Caucasian population. 5 However, the Asian population also consists of many races, with the Chinese population being one of them. The prevalence data in the Chinese population are lacking.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, the reported prevalence of PCLs ranged from 0.2 to 13.7% in the Asian population . The pooled rate of PCLs was higher in studies conducted in the USA than in Asia (12.6% vs 3.1%) . Therefore, the prevalence of PCLs may vary between different races.…”

Section: Introductionmentioning

confidence: 99%

“…2,4 The pooled rate of PCLs was higher in studies conducted in the USA than in Asia (12.6% vs 3.1%). 5 Therefore, the prevalence of PCLs may vary between different races. However, data in the Chinese population are lacking.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of pancreatic cystic lesions detected by magnetic resonance imaging in the Chinese population

Sun

Wang

Jiang

et al. 2019

J of Gastro and Hepatol

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Background and Aim Incidental pancreatic cystic lesions (PCLs) are being diagnosed more frequently. However, little is known about the prevalence of PCLs in the Chinese population. The aim of the study was to assess the crude prevalence of PCLs in individuals who underwent magnetic resonance imaging (MRI). Methods Data from consecutive patients who underwent MRI without pancreatic indications were included. MRI images were reviewed for the presence of pancreatic cysts. The prevalence of PCLs and high‐risk PCLs in different gender and age groups was calculated. To assess the crude prevalence, the prevalence and demographic data were standardized on the basis of Chinese national population data in 2017. Results A total of 10 987 individuals were included (7344 men). Incidental PCLs were identified in 212 individual (128 men). The prevalence of PCLs was 1.93%, and PCLs were more often discovered in women (1.74% vs 2.31%, P = 0.043). Prevalence increased with age (r = 0.804, P < 0.001). The prevalence of high‐risk PCLs was 0.12% (n = 13). Gender predominance and age distribution showed no difference between high‐risk PCLs and low‐risk PCLs (P = 0.234 and P = 0.855), but cysts located in the pancreatic head were more likely to develop into high‐risk PCLs (P = 0.001). After data standardization, the crude prevalence of PCLs was 1.31%, and PCLs were more often discovered in women (1.11% vs 1.5%, P < 0.001). The crude prevalence of high‐risk PCLs was 0.07%. Conclusion Pancreatic cystic lesions in the Chinese population are not rare. The prevalence of PCLs increased with age and is higher in the female population. The prevalence of high‐risk PCLs should not be ignored.

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Pancreatic Cysts—An Overview and Summary of Society Guidelines, 2021

Ayoub

Davis

Chapman

2021

JAMA

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Systematic review and meta-analysis: Prevalence of incidentally detected pancreatic cystic lesions in asymptomatic individuals

Cited by 148 publications

References 42 publications

Progression of pancreatic cystic lesions without any risk features is associated with initial cyst size and obesity

Progression of pancreatic cystic lesions without any risk features is associated with initial cyst size and obesity

Prevalence of pancreatic cystic lesions detected by magnetic resonance imaging in the Chinese population

Pancreatic Cysts—An Overview and Summary of Society Guidelines, 2021

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