Systematic review and meta-analysis on the association between phthalates exposure and insulin resistance

Shoshtari-Yeganeh, Bahareh; Zarean, Maryam; Mansourian, Marjan; Riahi, Roya; Poursafa, Parinaz; Teiri, Hakimeh; Rafiei, Nasim; Dehdashti, Bahare; Kelishadi, Roya

doi:10.1007/s11356-019-04373-1

Cited by 48 publications

(26 citation statements)

References 29 publications

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“…This shows that not only personal habits are important but also the overall living condition. Recently, The Diabetes Remission Clinical Trial (DiRECT) noted that weight loss in TDM patients led to liver fat loss and recovery of the β-cell function [141]. Also, in a recent systematic review and meta-analysis, authors observed that caloric deficient diet and periodic exercise ameliorated hepatic functions [142].…”

Section: Dietary and Lifestylementioning

confidence: 99%

The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)

Tănase

Gosav

Costea

et al. 2020

Journal of Diabetes Research

284

180

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Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa. This complex and intricate association is supported and mediated by insulin resistance (IR). In this review, we discuss the NAFLD immunopathogenesis, connection with IR and T2DM, the role of screening and noninvasive tools, and mostly the impact of the current antidiabetic drugs on steatosis liver and new potential therapeutic targets.

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Section: Dietary and Lifestylementioning

confidence: 99%

The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)

Tănase

Gosav

Costea

et al. 2020

Journal of Diabetes Research

284

180

View full text Add to dashboard Cite

show abstract

“…In our study we observed a positive association between ultra-processed food and urinary concentration of most phthalates and bisphenol, suggesting that contamination by contact materials may be an additional pathway to explain the associations seen between ultra-processed food and various health outcomes, as previously suggested by Srour [ 14 ]. Indeed, BPA exposure has been linked with higher risk of diabetes, general/abdominal obesity and hypertension [ 25 ] and phthalates with diabetes [ 26 ] and insulin resistance [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Ultra-processed foods are frequently packaged in materials that are a source of endocrine disrupting chemicals such as phthalates and bisphenol, associated with adverse health outcomes especially in pregnancy [ 23 , 24 ]. A large body of cross-sectional studies have specifically linked Bisphenol A (BPA) exposure with higher risk of diabetes, general/abdominal obesity, and hypertension [ 25 ] and phthalates with diabetes [ 26 ] and insulin resistance [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Association between dietary contribution of ultra-processed foods and urinary concentrations of phthalates and bisphenol in a nationally representative sample of the US population aged 6 years and older

2020

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Ultra-processed food consumption has been associated with several health outcomes such as obesity, hypertension, cardiovascular disease and cancer. The deleterious nutrient profile of these products, and the presence of food additives, neoformed contaminants and contact materials such as phthalates and bisphenol may be some of the potential pathways through which ultra-processed food influences disease outcomes. The aim of this study was to examine the association between dietary contribution of ultra-processed foods and urinary biomarker concentrations of parent compounds or their metabolites including Di(2-ethylhexyl) phthalate (ΣDEHP), Di-isononyl phthalate (ΣDiNP), Monocarboxynonyl phthalate (mCNP), Mono (3-carboxypropyl) phthalate (mCPP), Monobenzyl phthalate (mBzP), Bisphenol A (BPA), Bisphenol F (BPF) and Bisphenol S (BPS), in the US. Participants from the cross-sectional 2009–2016 National Health and Nutrition Examination Survey, aged 6+ years, with urinary measures and with one 24-hour dietary recall were included in the study. Ultra-processed foods were identified based on the NOVA classification system, a four-group food classification based on the extent and purpose of industrial food processing. Linear regression was used to compare average urinary creatinine-standardized concentrations across quintiles of energy contribution of ultra-processed foods. Models incorporated survey sample weights and were adjusted for different sociodemographic and life-style variables. Adjusted geometric means of ΣDiNP, mCNP, mCPP, mBzP and BPF increased monotonically from the lowest to the highest quintile of ultra-processed food consumption. As both phthalates/bisphenol and ultra-processed foods have been previously associated with insulin resistance, diabetes, general/abdominal obesity and hypertension, our results suggest the possibility of contact materials in ultra-processed foods as one link between ultra-processed food and these health outcomes. Future studies could confirm findings and further explore these mechanisms of action.

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“…2). EDCs linked to diabetes and/or alterations in insulin-glucose dynamics in human studies include arsenic, BPA, dioxins, organochlorine pesticides, PCBs and phthalates, among others [61][62][63][64][65][66][67][68][69][70][71][72]. In animal studies, disruptions in glucose homeostasis have been linked to arsenic, atrazine, BPA, cadmium, dioxins, malathion, particulate matter air pollution, PCBs, phthalates, persistent organic pollutants, tolylfluanid, and TBT .…”

Section: Exposures In Later Life and Metabolic Dysfunctionmentioning

confidence: 99%

Environmental neglect: endocrine disruptors as underappreciated but potentially modifiable diabetes risk factors

2019

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Type 2 diabetes prevalence is increasing dramatically across the globe, imposing a tremendous toll on individuals and healthcare systems. Reversing these trends requires comprehensive approaches to address both classical and emerging diabetes risk factors. Recently, environmental toxicants acting as endocrine-disrupting chemicals (EDCs) have emerged as novel metabolic disease risk factors. EDCs implicated in diabetes pathogenesis include various inorganic and organic molecules of both natural and synthetic origin, including arsenic, bisphenol A, phthalates, polychlorinated biphenyls and organochlorine pesticides. Indeed, evidence implicates EDC exposures across the lifespan in metabolic dysfunction; moreover, specific developmental windows exhibit enhanced sensitivity to EDC-induced metabolic disruption, with potential impacts across generations. Importantly, differential exposures to diabetogenic EDCs likely also contribute to racial/ethnic and economic disparities. Despite these emerging links, clinical practice guidelines fail to address this underappreciated diabetes risk factor. Comprehensive approaches to stem the tide of diabetes must include efforts to address its environmental drivers.

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Systematic review and meta-analysis on the association between phthalates exposure and insulin resistance

Cited by 48 publications

References 29 publications

The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)

The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)

Association between dietary contribution of ultra-processed foods and urinary concentrations of phthalates and bisphenol in a nationally representative sample of the US population aged 6 years and older

Environmental neglect: endocrine disruptors as underappreciated but potentially modifiable diabetes risk factors

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