Systematic Review and Meta-Analysis of the Prognostic Value of Serum High-Density Lipoprotein Cholesterol Levels for Solid Tumors

Hao, Bo; Bi, Baochen; Sang, Chen; Yu, Miaomei; Di, Dongmei; Luo, Guanghua; Zhang, Xiaoying

doi:10.1080/01635581.2019.1577983

Cited by 13 publications

(8 citation statements)

References 73 publications

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“…Two retrospective studies also showed that low HDL-C levels were strongly correlated with severity of epithelial ovarian cancer [20,28]. Although a metaanalysis including 25 studies with a total of 13,140 patients indicated that high serum HDL-C levels were associated with better OS and PFS in most of tumor types [29], the association between HDL-C and ovarian cancer still remains unclear. In our study, we have observed that patients with HDL-C level ≥ 1.19 mmol/L had a better PFS than patients with HDL-C level < 1.19 mmol/L (p = 0.001).…”

Section: Discussionmentioning

confidence: 99%

Associations of preoperative serum high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels with the prognosis of ovarian cancer

Lin

et al. 2021

Arch Gynecol Obstet

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BackgroundThe effect of serum lipids on ovarian cancer is controversial. We conduct this study to evaluate the prognostic value of preoperative plasma lipid pro le in patients with ovarian cancer. MethodsThe medical records of 156 epithelial ovarian cancer patients who underwent surgical resection in our department were retrospectively reviewed and analyzed. Serum lipids pro les, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), apolipoprotein A-(apoA-), apolipoprotein B (apoB) and clinicopathologic data were analyzed. Cox proportional hazards regression analyses and Kaplan-Meier method were performed to evaluate the overall survival (OS) and progression-free survival (PFS). ResultsMultivariable Cox regression analysis found that preoperative higher LDL-C level was signi cantly associated with worse OS (HR 2.088, 95% CI 1.052-4.147, p = 0.035), whereas higher HDL-C level showed signi cant association with better PFS (HR 0.491, 95% CI 0.247-0.975, p = 0.042). Further Kaplan-Meier survival analysis demonstrated that OS was longer for patients with low levels of LDL-C

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Section: Discussionmentioning

confidence: 99%

Associations of preoperative serum high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels with the prognosis of ovarian cancer

Lin

et al. 2021

Arch Gynecol Obstet

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“…Compared with young and early gastric cancer, elderly patients with advanced gastric cancer are heterogeneous and have a worse prognosis. The relationship between peripheral blood serum lipid profile (including total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol) and cancer has been studied by Hao [11], Wettstein, M.S [12] and Liu [13], but the results are inconsistent and there is no consensus. In this study, we analyzed the relationship between serum lipid profile and its clinicopathological features in 98 elderly patients with advanced gastric cancer, providing help for further subsequent studies.…”

Section: Discussionmentioning

confidence: 99%

Changes of Blood Lipid Metabolism in Elderly Patients with Advanced Gastric Cancer and Its Clinical Significance

2022

JCMP

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Objective: To investigate the contents of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) in peripheral blood of elderly patients with advanced gastric cancer, and to analyze their relationship with clinicopathological features. Methods: Ninety-eight patients older than 60 years and pathologically confirmed adenocarcinoma who were hospitalized in Hebei General Hospital from January 2017 to September 2020 were selected as the gastric cancer group; meanwhile, 100 healthy subjects in the same period were selected as controls. Their peripheral blood lipid and lipoprotein concentrations were measured, respectively. Results: The levels of TC, TG, HDL-C and LDL-C in the gastric cancer group were significantly lower than those in the healthy control group (P<0.05); the serum TC level in the gastric cancer group was negatively correlated with age, lymph node metastasis, and TNM stage (P<0.05); the serum TG level was significantly lower in those aged ≥ 70 years and with lymph node metastasis, and the serum TG level was higher in those with positive HER2 expression than in those with negative HER2 expression (P<0.05); the serum HDL-C level was higher in gastric cancer patients with tumor diameter ≥ 5cm than in those with tumor diameter < 5cm (P<0.05); the serum LDL-C level was higher in those without lymph node metastasis and stage III patients than in those with lymph node metastasis and stage IV (P<0.05), and in addition, the family history of gastric cancer was statistically significant with TC, TG, and LDL-C (P<0.05). Conclusion: Determination of serum TC, TG, HDL and LDL levels in patients with gastric cancer is helpful to determine the course and prognosis of patients with gastric cancer.

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“…(TC) and low-density lipoprotein cholesterol (LDL-C) are actuarially a protective factor for overall survival in cancer patients [50]. In another systematic review and meta-analysis, Hao, et al have concluded that high serum HDL-C levels are associated with better overall survival and disease-free survival in patients with solid tumors [51]. LDL, on the other hand, may have opposite functions in breast and other cancers [52].…”

Section: Cells In Attachment Vs In Suspension; 2d Vs 3d Cell Culturementioning

confidence: 99%

“…Cholesterol associate with LDL and HDL, or cholesterol derivatives are likely to have distinct and/or opposing effects [51][52][53][54][55]77]. Overall inhibition of fatty acid and/or cholesterol synthesis may thus induced complex outcomes.…”

Section: The Potential Interpretations For the Discrepancy In The Role Of Lipid Metabolism Reprograming In Cancermentioning

confidence: 99%

Lipid Metabolism Reprograming as a Target for Cancer

Xu¹

2019

Oncol Res Rev

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Targeting metabolic reprograming has emerged as an exciting area in cancer research. Lipids, and fatty acids and cholesterol in particular, have generally been considered to possess tumor promoting activities and have been targeted for cancer treatment in in vitro and in vivo studies, including clinical trials. Low fat diet has been accepted by the public as it is associated with human health. However, large body of evidence indicates the lack of scientific consensus in these areas. Updated contradictory data are presented in this paper with potential interpretations, which may significantly affect public diet selections and clinical practice in this area. Much greater efforts are needed in the area of nutrition research, in metabolic reprograming, and in lipid metabolism pertinent to cancer. These studies are pivotal to provide critical information for cancer prevention, detection, prognosis, and treatment.

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Systematic Review and Meta-Analysis of the Prognostic Value of Serum High-Density Lipoprotein Cholesterol Levels for Solid Tumors

Cited by 13 publications

References 73 publications

Associations of preoperative serum high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels with the prognosis of ovarian cancer

Associations of preoperative serum high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels with the prognosis of ovarian cancer

Changes of Blood Lipid Metabolism in Elderly Patients with Advanced Gastric Cancer and Its Clinical Significance

Lipid Metabolism Reprograming as a Target for Cancer

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