Systematic review and meta-analysis of combination therapy for smoking cessation

Shah, Sangeeta; Wilken, Lori; Winkler, Susan R.; Lin, Shio Jean

doi:10.1331/japha.2008.07063

Cited by 54 publications

(42 citation statements)

References 16 publications

(48 reference statements)

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“…Although this strategy is intuitive, its outcomes have not been studied in controlled trials. Pharmacological therapy with two controller agents to aid smoking cessation is recommended by some guidelines due to improved efficacy compared with single agents [103][104][105][106], but the optimal combination of agents and duration of therapy remains unknown.…”

Section: Managementmentioning

confidence: 99%

An official American Thoracic Society/European Respiratory Society statement: research questions in COPD

et al. 2015

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Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality, and resource use worldwide. The goal of this official American Thoracic Society (ATS)/European Respiratory Society (ERS) research statement is to describe evidence related to diagnosis, assessment and management; identify gaps in knowledge; and make recommendations for future research. It is not intended to provide clinical practice recommendations on COPD diagnosis and management.Clinicians, researchers, and patient advocates with expertise in COPD were invited to participate. A literature search of Medline was performed, and studies deemed relevant were selected. The search was not a systematic review of the evidence. Existing evidence was appraised and summarised, and then salient knowledge gaps were identified.Recommendations for research that addresses important gaps in the evidence in all areas of COPD were formulated via discussion and consensus.Great strides have been made in the diagnosis, assessment and management of COPD, as well as understanding its pathogenesis. Despite this, many important questions remain unanswered. This ATS/ ERS research statement highlights the types of research that leading clinicians, researchers, and patient advocates believe will have the greatest impact on patient-centred outcomes. @ERSpublications ATS/ERS statement: which types of research will have the greatest future impact on patientcentred outcomes in COPD? http://ow.ly/I54Hb

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Section: Managementmentioning

confidence: 99%

An official American Thoracic Society/European Respiratory Society statement: research questions in COPD

et al. 2015

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“…A systematic review of combination therapy for smoking cessation that included nicotine patch plus one other agent such as nicotine gum or bupropion SR found combination therapy to be more effective than monotherapy for tobacco cessation. 43 A recent study of triple-combination pharmacotherapy for smoking in medically ill patients found the combination of medications to be more effective than standard-duration nicotine patch treatment. 44 Other strategies include combining medication and behavioral counseling.…”

mentioning

confidence: 99%

Smoking behavior and delivery of evidence-based care for veterans with spinal cord injuries and disorders

Weaver

Smith

LaVela

et al. 2011

The Journal of Spinal Cord Medicine

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Objective: Little is known about those veterans with spinal cord injuries and disorders (SCI/D) who smoke cigarettes. This study identified the factors associated with smoking in this population, motivations for smoking, and the readiness for smoking cessation. Current practices for the delivery of evidence-based tobacco cessation were also examined. Design: Methods included surveys of veterans with SCI/D, medical record reviews of current smokers, and telephone interviews with SCI/D providers. Setting: Six Veterans Health Administration facilities with SCI centers and one SCI clinic. Participants: Survey data were analyzed for 1210 veterans, 256 medical records were reviewed, and 15 providers served as key informants. Interventions: Observational study. Outcome measures: Veterans self-reported smoking status, quit attempts, methods and care received, motivation for smoking, and health care conditions. Medical record review and informant interviews examined the tobacco cessation care provided. Results: Whereas 22% of the respondents were current smokers; 51% were past smokers. Current smokers more often reported respiratory illnesses and/or symptoms, alcohol use, pain, and depression than past or never smokers, and approximately half made quit attempts in the past year. Smokers received referral to counseling (57%) and/or prescription for medication/nicotine replacement (23%). Key informants identified difficulty of providing follow-up and patients' unwillingness to consider quitting as barriers. Conclusion: Veterans with SCI/D who smoke also had other health problems. Providers offer counseling and medication, but often have difficulty following patients to arrange/provide support. Identifying other support methods such as telehealth, considering the use of combination cessation therapies, and addressing other health concerns (e.g. depression) may affect tobacco cessation in this population.

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“…Combining pharmacological and/or nonpharmacological interventions appears to improve SC in comparison to no intervention [117,118,119] or to monotherapy (RR = 1.54, CI = 1.19-2.00) [118]. …”

Section: Resultsmentioning

confidence: 99%

Environmental and Genomic Factors as well as Interventions Influencing Smoking Cessation: A Systematic Review of Reviews and a Proposed Working Model

Viron¹,

Malats²,

Heyden³

et al. 2013

Public Health Genomics

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Background: Smoking behaviour is a major public health problem worldwide. Several sources have confirmed the implication of genomic factors in smoking behaviour. These factors interact both with environmental factors and interventions to develop a certain behaviour. Objectives: Describing the environmental and genomic factors as well as the interventions influencing smoking cessation (SC) and developing a working model incorporating the different factors influencing SC were our main objectives. Methods: Two systematic reviews were conducted using articles in English from the Cochrane library, PubMed and HuGENet from January 2000 to September 2012: (1) a systematic review of systematic reviews and meta-analyses and (2) a systematic review of original research for genomic factors. The proposed working model was developed by making use of previous models of SC and applying an iterative process of discussion and re-examination by the authors. Results: We confirmed the importance of the 4 main factors influencing SC: (1) environmental factors, (2) genomic factors, (3) gene-environment interactions, and (4) evidence-based interventions. The model demonstrates the complex network of factors influencing SC. Conclusion: The working model of SC proposed a global view of factors influencing SC, warranting future research in this area. Future testing of the model will consolidate the understanding of the different factors affecting SC and will help to improve interventions in this field.

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Systematic review and meta-analysis of combination therapy for smoking cessation

Cited by 54 publications

References 16 publications

An official American Thoracic Society/European Respiratory Society statement: research questions in COPD

An official American Thoracic Society/European Respiratory Society statement: research questions in COPD

Smoking behavior and delivery of evidence-based care for veterans with spinal cord injuries and disorders

Environmental and Genomic Factors as well as Interventions Influencing Smoking Cessation: A Systematic Review of Reviews and a Proposed Working Model

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