Systematic review and meta-analysis of safety and efficacy of high-intensity focused ultrasound (HIFU) for face and neck rejuvenation

Ayatollahi, Azin; Gholami, Jaleh; Saberi, Maryam; Hosseini, Hamed; Firooz, Alireza

doi:10.1007/s10103-020-02957-9

Cited by 17 publications

(25 citation statements)

References 17 publications

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“…The pain score reported to be low to moderate depending on with or without using analgesics/anesthetics in the literature. 14 In a split face comparison of two different MFU device pain was reported to be much more severe after Ulthera than Ultra-Skin treatment. 15 Two devices were found to have similar efficacy in blinded clinician and quantitative assessment, although there were some differences in patient satisfaction in favor of Ulthera.…”

Section: Resultsmentioning

confidence: 99%

“…Although anesthetics or analgesics were not used in our study, subjects experienced only minimal pain during the treatment. The pain score reported to be low to moderate depending on with or without using analgesics/anesthetics in the literature 14 . In a split face comparison of two different MFU device pain was reported to be much more severe after Ulthera than Ultra‐Skin treatment 15 .…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of microfocused ultrasound for improving skin laxity in the lower face: A retrospective study

Yalıcı-Armağan

Elçin

2020

Dermatologic Therapy

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To evaluate the efficacy and safety of a newer microfocused ultrasound (MFU) device on the lower face laxity. Subjects who underwent MFU therapy for skin tightening were enrolled in the study. The primary outcome measure was overall improvement in skin laxity of the lower face that was evaluated by improvement on jawline irregularities, marionette line, and submental laxity. Assessments were obtained from two blinded dermatologists paired pre-and post-treatment photographs with Investigator-Global-Aesthetic-Improvement-Scale (IGAIS) and from subjects with Subject-GAIS (SGAIS). A total of 24 subjects were evaluated on a median of 4.3 months after 1 session MFU application. According to IGAIS, 5 subjects (20.9%) demonstrated improvement and 15 subjects (62.5%) had no change. Four subjects (16.7%) were scored as worsening. According to SGAIS, 11 subjects (45.9%) reported an improvement whereas 9 subjects (37.5%) reported no change. There was a statistically significant difference between the improvement rate assessed by the investigators and the subjects, where investigators scored lower (P = .006). No serious adverse effects were observed. The relatively high improvement rate observed by the subjects' self assessments compared to investigators evaluation from the photographs suggested that we need to find new evaluation methods other than photography which may reflect what subjects feel but we cannot see.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of microfocused ultrasound for improving skin laxity in the lower face: A retrospective study

Yalıcı-Armağan

Elçin

2020

Dermatologic Therapy

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“…Our study is the first to report the use of a 6-mm deep transducer in facial rejuvenation, especially on the hair-bearing region of the temporal area, which is typically used on other body regions. 12 , 14 Kwon et al proved a 6-mm transducer has benefits for tightening and rejuvenation of the area with unwanted fat. 23 Because both the skin and fat of the lateral temporal and cheek regions are relatively thick, 4.5- and 6-mm transducers were employed to target the SMAS or deeper layers.…”

Section: Discussionmentioning

confidence: 99%

“…The application of HIFU transducers to the upper to midface is also limited to only one or two focal depths. 14 Suh et al 11 reported clinical and histologic improvements in a study on 22 Korean participants after treatment with a single HIFU transducer on the forehead (3 mm, 0.3–0.35 J), temples (3 mm, 0.35 J), and malar areas. Park et al 5 recorded a significant tightening of infraorbital laxity in seven patients treated with 1.5-mm (0.2 J) and 3-mm (0.45 J) focal depth transducers (with a total of 30 treatment lines).…”

Section: Discussionmentioning

confidence: 99%

“…Thus far, no consensus has been reached on the ideal objective measurements for aesthetics. Traditional assessment tools, such as the Global Aesthetic Improvement Scale (GAIS) and wrinkle severity rating scale (WSRS), completed by both patients and physicians before and after treatment, are commonly used to assess HIFU treatment, 14 but these 5-point scales cannot accurately represent treatment efficacy. 14 , 15 Alam et al 19 also evaluated the outcomes of HIFU treatment in eyebrow lifting by using fixed landmarks but measuring only linear changes and not employing anatomical landmarks on the lower face.…”

Section: Discussionmentioning

confidence: 99%

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Quantified Facial Rejuvenation Utilizing High Intense Focus Ultrasound with Multiple Penetrative Depths

Lio

Chang

Chuang

et al. 2022

CCID

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Background Multiple penetration depths of high-intensity focused ultrasound (HIFU) treatment for facial rejuvenation have not been quantified. Methods We enrolled 12 participants (n=24) to undergo one session of HIFU rejuvenation between January 1, 2019, and January 10, 2020. We used a 2-, 4.5-, and 6-mm focal depth transducer on the upper and middle face. We evaluated efficacy on days 60 and 90 by using our specific assessment system. Results The average eyebrow peak and pupil–eyebrow peak angles significantly increased by 2° (p < 0.0005) and decreased by 1° (p < 0.0001), respectively, at day 90. The shortened eyebrow–iris length indicated that the forehead tissues had lifted and moved medially to the central face. Supraorbital tissues were also vertically elevated, marked by the eyebrow–orbital (p = 0.0016) and vertical palpebral fissure lengths (p = 0.0052), which both exhibited a 0.8-cm elevation. For the midface, the increased canthus–oral–nasal angle (p = 0.5881) and decreased tragus–oral length (p = 0.5881) indicated that laxity had been corrected through lifted oral commissure, though the data were not statistically significant. No serious side effects were observed. Conclusion HIFU treatment with multiple depths quantitatively improved both upper-facial rejuvenation and midface rejuvenation after a single session.

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Water‐Responsive Self‐Contractive Silk‐Based Skin Anti‐Aging Tensioners with Customizable Biofunctions

Xie,

Geng,

et al. 2024

Adv Healthcare Materials

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Skin anti‐aging treatments have become increasingly popular. Currently, the prevalent treatment method involves implanting skin tension regulation threads (skin lifting threads) under the skin, and radiofrequency treatments. In this study, inspired by the natural supercontraction of spider silk, we have modulated the molecular structure of silk fibroin fibers into an oriented configuration. This modification endows silk proteins with water‐responsive self‐contraction capabilities, leading to the development of innovative self‐contracting silk‐based skin tensioners (SSSTs). To align with clinical requirements, skin tension regulation materials were functionalized by testing for their self‐contraction, near‐infrared laser heating function, and bacteriostatic properties. The SSSTs exhibited remarkable self‐contraction properties, drug‐loading and sustained‐release capabilities, notable antibacterial effects, controllable degradation, and good biocompatibility. Moreover, the near‐infrared light heating function effectively increased subcutaneous temperature, demonstrating its potential for enhancing and prolonging skin lifting effects. Therefore, SSSTs can be applied for skin tension regulation to improve and delay skin aging. Our results might pave the way for novel strategies in skin rejuvenation, with broad implications for the field of skin anti‐aging.This article is protected by copyright. All rights reserved

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Systematic review and meta-analysis of safety and efficacy of high-intensity focused ultrasound (HIFU) for face and neck rejuvenation

Cited by 17 publications

References 17 publications

Evaluation of microfocused ultrasound for improving skin laxity in the lower face: A retrospective study

Evaluation of microfocused ultrasound for improving skin laxity in the lower face: A retrospective study

Quantified Facial Rejuvenation Utilizing High Intense Focus Ultrasound with Multiple Penetrative Depths

Water‐Responsive Self‐Contractive Silk‐Based Skin Anti‐Aging Tensioners with Customizable Biofunctions

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