Systematic review and meta-analysis of the correlation between intestinal flora and gestational diabetes mellitus

Abstract

Background: A meta-analysis was conducted on the correlation between intestinal flora and gestational diabetes mellitus (GDM) to provide a theoretical basis for the treatment of GDM.Methods: The PubMed, Embase, MEDLINE, Ovid, Springer, and Web of Science databases were searched from the establishment of the databases to December 31, 2020, to retrieve randomized control trials (RCTs) involving GDM patients. The Cochrane Handbook for Systematic Reviews of Intervention 5.0.2 was used to assess the bias risk of the included articles, and Rev Man 5.3 was used for the meta-analysis.Results: A total of 7 studies were included in the meta-analysis, comprising 665 study participants.The meta-analysis results showed that the GDM patients in the experimental group had a lower level of Bifidobacterium [MD (mean difference) =-2.49; 95% confidence interval (CI) -3.54 to -1.45; Z=4.66;

Probiotics for preventing gestational diabetes mellitus in overweight or obese pregnant women: A systematic review and meta-analysis

“…The correlation between intestinal probiotics and diabetes has been confirmed [30]. Ding, et, al found that the levels of intestinal bacteria, other strains, and inflammatory factors increased when the level of probiotics was decreased [31]. For pregnant women, probiotics demonstrated great ability in GDM management [32,33].…”

Association of dietary inflammatory index with risk of gestational diabetes mellitus and preeclampsia: a systematic review and meta-analysis

“…Gut microbiota are essential modulators of immune homoeostasis, and diet can directly or indirectly affect the composition of gut microbiota, which is associated with gut barrier function (45,46) . For example, a long-term high-fat diet decreases the expression of tight junction proteins in gut epithelial cells and increases the permeability of the gut mucosa, which fails to act as an integral barrier to migrating pathogens; thus, a large amount of bacterial lipopolysaccharide is released into the blood, activating the low-grade chronic inflammation of islets, and inflammation can lead to the structural damage and dysfunction of pancreatic islet B cells, promote B cell apoptosis and cause insufficient insulin secretion, which in turn triggers GDM (46) . However, several limitations of this study should be considered when interpreting the findings of this study.…”

Oral probiotics increased the proportion of Treg, Tfr, and Breg cells to inhibit the inflammatory response and impede gestational diabetes mellitus

“…Another study also showed that the abundance of gut microbiota in GDM patients was abnormal at both the phylum and genus levels compared to healthy controls (Chen et al 2021a , b ). In addition, probiotics play an important role in regulating the gut microbiota composition in patients with GDM (Ding et al 2021 ).…”