Probiotics for preventing gestational diabetes mellitus in overweight or obese pregnant women: A systematic review and meta-analysis

Chu, Xiajing; Yan, Peijing; Zhang, Na; Feng, Lijun; Li, Xiuxia; Wang, Yongfeng; Yang, Kehu

doi:10.1016/j.clnesp.2022.05.007

Cited by 9 publications

(9 citation statements)

References 35 publications

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“… Probiotics may enhance the probability of pre-eclampsia, including superimposed. [ 43 ] RCTs: randomized clinical trials, GDM: gestational diabetes mellitus, CFUs: colony-forming units, and BMI: body mass index. …”

Section: Resultsmentioning

confidence: 99%

“…Hence, future high-quality RCTs are supported to be performed [ 42 ]. In another recent meta-analysis including five RCTs with 1048 pregnant women affected by overweight or obesity, the results suggest that probiotics may enhance the probability of pre-eclampsia, including superimposed [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

“…In contrast to the previous studies, this study found a significantly lower prevalence (32.5%) of excessive GWG in pregnant women receiving probiotics compared to the incidence (46%) of women receiving placebo [ 68 ]. In contrast, a recent meta-analysis including five RCTs, which all administrated diverse species of Lactobacillus and Bifidobacterium , did not find any significant difference between the effects of probiotics supplementation and placebo on excessive GWG in participants affected by overweight or obesity during gestation [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

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Probiotics Supplementation during Pregnancy: Can They Exert Potential Beneficial Effects against Adverse Pregnancy Outcomes beyond Gestational Diabetes Mellitus?

Poulios,

Pavlidou,

Papadopoulou

et al. 2024

Biology

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Background: Probiotics, as supplements or food ingredients, are considered to exert promising healthy effects when administered in adequate quantity. Probiotics’ healthy effects are related with the prevention of many diseases, as well as decreasing symptom severity. Currently, the most available data concerning their potential health effects are associated with metabolic disorders, including gestational diabetes mellitus. There is also clinical evidence supporting that they may exert beneficial effects against diverse adverse pregnancy outcomes. The purpose of the current narrative study is to extensively review and analyze the current existing clinical studies concerning the probable positive impacts of probiotics supplementation during pregnancy as a protective agent against adverse pregnancy outcomes beyond gestational diabetes mellitus. Methods: a comprehensive and thorough literature search was conducted in the most precise scientific databases, such as PubMed, Scopus, and Web of Sciences, utilizing efficient, representative, and appropriate keywords. Results: in the last few years, recent research has been conducted concerning the potential beneficial effects against several adverse pregnancy outcomes such as lipid metabolism dysregulation, gestational hypertensive disorders, preterm birth, excessive gestational weight gain, caesarean risk section, vaginal microbiota impairment, mental health disturbances, and others. Conclusion: up to the present day, there is only preliminary clinical data and not conclusive results for probiotics’ healthy effects during pregnancy, and it remains questionable whether they could be used as supplementary treatment against adverse pregnancy outcomes beyond gestational diabetes mellitus.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Probiotics Supplementation during Pregnancy: Can They Exert Potential Beneficial Effects against Adverse Pregnancy Outcomes beyond Gestational Diabetes Mellitus?

Poulios,

Pavlidou,

Papadopoulou

et al. 2024

Biology

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“…The effect of probiotics on preventing GDM in overweight or obese pregnant women has been the subject of debate in current systematic reviews and meta-analysis[ 9 , 10 ]. The study by Chu et al [ 9 ] found that there were no signiﬁcant differences between probiotics and placebo on GDM and suggested that probiotics were not a promising approach to prevent GDM and promote the health of subsequent generations. However, the latest meta-analysis carried out in China reported that probiotics can effectively prevent GDM in overweight and obese pregnant women[ 10 ].…”

Section: Effects Of Probiotics On Glucose Metabolism In Overweight/ob...mentioning

confidence: 99%

“…The administration of probiotics may reduce body weight, although the effect sizes are small[ 31 , 66 , 67 ]. However, the latest systematic reviews and meta-analyses in 2022 showed that there were no significant differences between probiotics and placebo on excess weight gain in overweight/obese pregnant women[ 9 , 10 ].…”

Section: Effects Of Probiotics On Other Maternal and Infant Outcomes ...mentioning

confidence: 99%

Probiotics for preventing gestational diabetes in overweight or obese pregnant women: A review

Deng¹,

Li-ping²,

Liu³

2022

World J Clin Cases

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Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit to the host. Specific probiotics or probiotic foods can be used to reduce the risk of diseases associated with aberrant gut microbiota composition. The incidence of gestational diabetes mellitus (GDM) has increased annually with the proportion of overweight and obese people. Overweight or obese pregnant women are at high risk of GDM and have obvious changes in gut microbiota compared with normal-weight pregnant women. Specific probiotics or probiotic foods may alter gut microbiota in overweight or obese pregnant women and inhibit the expression of inflammatory factors, consequently resulting in weight loss and reduced insulin resistance. This review discusses the mechanism of probiotics on GDM, as well as the dose, method and duration of probiotics use, and summarizes current evidence on probiotics in improving glucose metabolism and other maternal and infant outcomes in overweight/obese pregnant women.

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Shaping Microbiota During the First 1000 Days of Life

Samarra,

Flores,

Bernabeu

et al. 2024

Advances in Experimental Medicine and Biology

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Probiotics for preventing gestational diabetes mellitus in overweight or obese pregnant women: A systematic review and meta-analysis

Cited by 9 publications

References 35 publications

Probiotics Supplementation during Pregnancy: Can They Exert Potential Beneficial Effects against Adverse Pregnancy Outcomes beyond Gestational Diabetes Mellitus?

Probiotics Supplementation during Pregnancy: Can They Exert Potential Beneficial Effects against Adverse Pregnancy Outcomes beyond Gestational Diabetes Mellitus?

Probiotics for preventing gestational diabetes in overweight or obese pregnant women: A review

Shaping Microbiota During the First 1000 Days of Life

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