Systematic Review and Meta-Analysis of Randomized Clinical Trials on Chemomechanical Caries Removal

Abstract

It was found that none of the current reviewed trials fulfilled all the ideal requirements of clinical trials. Furthermore, the current scientific evidence shows that the sodium hypochlorite-based (Carisolv) chemomechanical caries removal method was more time consuming when compared to the enzyme-based (Papacarie) chemomechanical and the conventional caries removal methods. Further prospective randomized controlled clinical trials evaluating the long-term follow-up of papain-treated permanent teeth are needed.

Effects of Papacarie on children with dental caries in primary teeth: a systematic review and meta‐analysis

“…In addition, the outcome variables in previous systematic reviews are also limited. Mainly previous studies only compare the treatment time. Therefore, there is a lack of the comparison in reducing the cariogenic microbiota before and after the caries removal and pain perception in caries removal treatment.…”

“…Most children are satisfied with this method, according to research on their preference research of the conventional method and Papacarie. Several investigators, however, have noted the efficacy of Papacarie is questionable, and it may increase the treatment time. This inconclusive evidence is not advantageous for clinical application and the promotion of Papacarie for caries removal in primary teeth among children.…”

Effects of Papain-Based Gel Used For Caries Removal on Macrophages and Dental Pulp Cells

“…This method can minimize the unpleasant perception that occur during caries removal by the conventional method (3). Some methods are becoming more popular and being improved to minimize the number of interventions and to maximize the preservation of dental tissues during removal of carious tissues (4).…”

Deri̇n Denti̇n Çürükleri̇ni̇n Tedavi̇si̇nde Alternati̇f Yeni̇ Yöntemler

“…23 Günümüzde kullanılmakta olan enzim bazlı kemomekanik ajanlar ise; Papacarie (Formula and Acao, Sao Paulo, Brezilya) ve hala deneysel aĢamada olan Biosolv (SFC-V and SFC-VIII, 3M- Kemomekanik yöntemlerin çürüğün uzaklaĢtı-rılmasındaki etkinliği diğer yöntemlerle benzer olsa da dezavantaj olarak uygulama daha uzun sürmekte ve jelin uygulanacağı çürük alanına ulaĢmak veya en son kavite sınırlarını düzeltmek amacıyla frezlerin kullanılması gerekmektedir. 5,17,21,25,[30][31][32][33] 3.Çürük Boyaları: Çürük boyalarının kulanı-mının ilk kez 1970'lerde Fusayama tarafından kulanı-lan bazik fuksin ile gündeme geldiği bildirilmiĢtir. 34 Bazik fuksin, propilen glikol içerisinde %1 asit kırmızı ve povidon iyodür çürük boyası olarak kullanılmıĢtır ancak genotoksisite çalıĢmalarında bazik fuksinin ciddi mutajenik etkileri gözlenmiĢtir.…”