Systematic nodal dissection in the intrathoracic staging of patients with non–small cell lung cancer

Graham, Alastair; Chan, KM John; Pastorino, Ugo; Goldstraw, Peter

doi:10.1016/s0022-5223(99)70419-8

Cited by 146 publications

(71 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1,2 Significant difference existed between these two groups regarding the surgical method and the scope of lymph node dissection. [2][3][4][5] Sublobar resection could be acceptable for pre-invasive lesion, while the standard surgical treatment for IPA should be lobectomy. [2][3][4][5] Skip metastases involving mediastinal lymph nodes, without hilar lymph nodes appeared mostly in the IPA group, thus the scope of lymph node dissection for the IPA group should be larger than for the pre-invasive lesion group.…”

Section: Introductionmentioning

confidence: 99%

Using the CT features to differentiate invasive pulmonary adenocarcinoma from pre-invasive lesion appearing as pure or mixed ground-glass nodules

Liang¹,

Xu²,

Xu³

et al. 2015

BJR

View full text Add to dashboard Cite

The authors Jing Liang and Xiao-quan Xu contributed equally to this article.Objective: To differentiate pre-invasive lesion from invasive pulmonary adenocarcinoma (IPA) appearing as ground-glass nodules (GGNs) using CT features. Methods: 149 GGNs were enrolled in this study, with 74 pure GGNs (p-GGNs) and 75 mixed GGNs (m-GGNs). Firstly, univariate analysis was used to analyse the difference of CT features between pre-invasive lesion and IPA. Then, multivariate analysis was conducted to identify variables that could independently differentiate pre-invasive lesion from IPA. Receiver operating characteristic curve analysis was performed to evaluate the differentiating value of identified variables. Results: In the p-GGNs, multivariate analysis showed that the amount of blood vessels was an independent risk factor. Using the amount of blood vessels "$1" as the diagnostic criterion, we could diagnose IPA with a sensitivity of 100%. Using the amount of blood vessels "50" as the diagnostic criterion, we could diagnose pre-invasive lesions with a specificity of 100%. In the m-GGNs, multivariate analysis showed that the volume of solid portion (V Solid ) and pleural indentation were two independent risk factors. One further model was constructed using these two variables: model 5 2.508 3 (V Solid 1 1.407) 3 (pleural indentation 2 1.016). Using the new model, improved diagnostic ability was achieved compared with using V Solid or pleural indentation alone. Conclusion: The amount of blood vessels through the p-GGNs would be an important criterion during clinical management, while V Solid and pleural indentation seemed important for m-GGNs. Moreover, the new model could further improve the differentiating value for m-GGNs. Advances in knowledge: CT features are useful in differentiating pre-invasive lesion from IPA appearing as GGNs. INTRODUCTIONAccording to the new pathological classification constituted in 2011, lung adenocarcinoma was divided into the preinvasive lesion group and the invasive pulmonary adenocarcinoma (IPA) group.1,2 Significant difference existed between these two groups regarding the surgical method and the scope of lymph node dissection.2-5 Sublobar resection could be acceptable for pre-invasive lesion, while the standard surgical treatment for IPA should be lobectomy.2-5 Skip metastases involving mediastinal lymph nodes, without hilar lymph nodes appeared mostly in the IPA group, thus the scope of lymph node dissection for the IPA group should be larger than for the pre-invasive lesion group.2-5 Therefore, accurate differentiation between preinvasive and IPA lesions before surgery was crucial, particularly for surgery planning, prognosis assessment and doctor-patient communication.

show abstract

Section: Introductionmentioning

confidence: 99%

Using the CT features to differentiate invasive pulmonary adenocarcinoma from pre-invasive lesion appearing as pure or mixed ground-glass nodules

Liang¹,

Xu²,

Xu³

et al. 2015

BJR

View full text Add to dashboard Cite

show abstract

“…As the localization of the tumor distanced from peripheral, segmental, bronchial, or lobar bronchial to main bronchial, the rate of lymph node metastasis was found to be 27%, 42%, 68% and 73%, respectively, and statistically significant. [9] In this study, it was demonstrated that in central tumors, both N 1 and N 2 metastases were significantly more frequent. [9] In our study, we determined that both N 1 and N 2 metastases were increased in tumors with EBLs.…”

Section: Discussionmentioning

confidence: 54%

“…[9] In this study, it was demonstrated that in central tumors, both N 1 and N 2 metastases were significantly more frequent. [9] In our study, we determined that both N 1 and N 2 metastases were increased in tumors with EBLs. The increase in N 1 metastasis was statistically significant, whereas the increase in N 2 metastasis was not.…”

Section: Discussionmentioning

confidence: 54%

“…[7,8] However, to our knowledge, there is no study concerning the relationship between the presence of EBL and lymph node metastasis and its effect on survival, which is our hypothesis subject; we detected in the literature only a few studies that are close to our perspective indirectly. [9,10] Ito et al [10] evaluated a tumor that was related to the extrapulmonary bronchus or localized in the extrapulmonary bronchus as central type and other tumors that did not meet these criteria as peripheral type. Ketchedjian et al [7] performed bronchoscopy preoperatively rather than thorax computed tomography to determine the tumor localization as central or peripheral as we also did in our study.…”

Section: Discussionmentioning

confidence: 99%

“…These findings support our study. Moreover, Graham et al [9] showed that lymph node metastasis rate increased as the tumors moved from peripheral to central areas. As the localization of the tumor distanced from peripheral, segmental, bronchial, or lobar bronchial to main bronchial, the rate of lymph node metastasis was found to be 27%, 42%, 68% and 73%, respectively, and statistically significant.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Does endobronchial lesion affect the lymph node status in non-small cell lung cancer?

Akçay¹

2017

Turk Gogus Kalp Dama

View full text Add to dashboard Cite

ÖZAmaç: Bu çalışmada küçük hücreli dışı akciğer kanserinde endobronşiyal lezyon ile hiler veya mediastinal lenf nodu metastazı arasında ilişki olup olmadığı değerlendirildi. Bul gu lar: Endobronşiyal lezyonu olan (n=174) ve olmayan hasta gruplarında (n=513) ki-kare analizi ile yapılan değerlendirmede endobronşiyal lezyon varlığı ve hiler lenf nodu metastazı durumu arasında anlamlı bir ilişki saptanır iken (p= 0.014) endobronşiyal lezyon varlığı ve aynı taraf mediastinal lenf nodu metastazı durumu arasında anlamlı bir ilişki saptanmadı (p= 0.383). Endobronşiyal lezyonu olan ve olmayan hastalarda beş yıllık sağkalım sırası ile %58.6 ve %40.2 olup aralarında istatistiksel olarak anlamlı farklılık vardı (p<0.001).So nuç: Endobronşiyal lezyonu olan küçük hücreli dışı akciğer kanseri olgularında hiler lenf nodu metastazı anlamlı olarak daha sık görülmektedir. Bu durum peribronşiyal lenfatikler aracılığı ile metastaz gelişebileceği yönünde şüphe uyandırmaktadır.Anah tar söz cük ler: Endobronşiyal lezyon; akciğer kanseri; lenf nodu metastazı. ABSTRACTBackground: This study aims to evaluate whether or not there is a relationship between endobronchial lesion and hilar and/or mediastinal lymph node metastasis in non-small cell lung cancer.

show abstract

Serum vascular endothelial growth factor‐C level in patients with primary nonsmall cell lung carcinoma

Tamura

Ohta

2003

Cancer

View full text Add to dashboard Cite

For pressure‐sensitive adhesives (PSAs) composed of poly(co‐ethyl acrylate‐2‐ethylhexyl acrylate‐2‐hydroxyethyl methacrylate) as a base resin and polyisocyanate as a crosslinker, the relationship between the crosslinking reaction and peel strength was investigated. A 90° peel test of cured PSA films under various storage conditions was carried out. At the same time, the isocyanate (NCO) consumption in these PSA films was monitored by attenuated total reflectance/Fourier transform infrared spectroscopy. The peel strength of the PSA compounded with the crosslinker decreased as the NCO groups were consumed. The elevation of the aging temperature promoted the crosslinking reaction and increased the decrement in the peel strength. The peel strength of noncrosslinked and crosslinked PSA films increased with the contact time. A high storage temperature made the increment in the peel strength increase. The addition of the crosslinker to the PSA films reduced the increment in the peel strength. Furthermore, PSA films with residual NCO groups possessed stronger peel strengths than fully cured films. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 87: 1493–1499, 2003

show abstract

Systematic nodal dissection in the intrathoracic staging of patients with non–small cell lung cancer

Abstract: Because no clinical or pathologic subset of patients with a negligible incidence of N2 disease could be discriminated, systematic nodal dissection must be routinely employed for accurate intrathoracic staging of non-small cell lung cancer.

Cited by 146 publications

References 24 publications

Using the CT features to differentiate invasive pulmonary adenocarcinoma from pre-invasive lesion appearing as pure or mixed ground-glass nodules

Using the CT features to differentiate invasive pulmonary adenocarcinoma from pre-invasive lesion appearing as pure or mixed ground-glass nodules

Does endobronchial lesion affect the lymph node status in non-small cell lung cancer?

Serum vascular endothelial growth factor‐C level in patients with primary nonsmall cell lung carcinoma

Contact Info

Product

Resources

About