Systematic investigation of ethanolic extract from Leea macrophylla : Implications in wound healing

Joshi, A. C.; Joshi, Vinod Kumar; Pandey, Daya Shankar; Hemalatha, S

doi:10.1016/j.jep.2016.06.034

Cited by 32 publications

(38 citation statements)

References 50 publications

(44 reference statements)

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“…The wounds were then closed with interrupted sutures at a distance of 1 cm. Both topical and oral treatments were continued up to 10 days, where sutures were removed on the 6th day and wound breaking strength (WBS) was determined on the 10th post‐wounding day using standard procedure …”

Section: Methodsmentioning

confidence: 99%

Wound healing potential of Solanum xanthocarpum in streptozotocin-induced diabetic rats

Parmar

Shende

Katare

et al. 2018

Journal of Pharmacy and Pharmacology

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Section: Methodsmentioning

confidence: 99%

Wound healing potential of Solanum xanthocarpum in streptozotocin-induced diabetic rats

Parmar

Shende

Katare

et al. 2018

Journal of Pharmacy and Pharmacology

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“…Reactive oxygen species is one of the endogenous aggressive factors in ulcer and can be excluded by augmenting articulation of antioxidant enzymes such as SOD, CAT and GSH or by eliminating the free radicals like LPO [43,44]. Generation of free radicals including peroxynitrite and hydroxyl radicals are inhibited by an elevated level of superoxide dismutase (SOD) as a result of dismutation of superoxide radicals.…”

Section: Discussionmentioning

confidence: 99%

Anti-Ulcer Study of Standardized Ethanol Root Extract of Aganosma Dichotoma and Isolated Ursolic Acid

Pandey

Joshi

Hemalatha

2017

Int J Pharm Pharm Sci

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Objective: Aganosma dichotoma K. Schum (Apocynaceae) has been traditionally used as an Ayurvedic ulcer treatment and the study scientifically validates the antiulcer effect of A. dichotoma ethanol root extract (EAD). Methods:The studies included the isolation, quantification of ursolic acid through HPTLC. Acute and sub-acute toxicity study of EAD for 28 d and antiulcer effect of ursolic acid (50 mg/kg, p. o.), EAD (100, 200 and 400 mg/kg, p. o.) were also evaluated on both the physical (pyloric ligation, PL; cold restrain stress, CRS;) and chemical (absolute ethanol, aspirin, ASP;) induced ulcer in Charles Foster albino rats for 7 d. The various gastric-ulcer parameters, viz. gastric pH, volume, acid-pepsin output, DNA content, H + K + -ATPase activity, mucus content, microvascular permeability, antioxidant enzyme, and gastric histopathological study were performed. Results:The isolated ursolic acid was characterized by NMR and mass spectrometer and quantified through HPTLC in EAD (4.26% w/w). Acute oral toxicity study indicated that LD50 of extract was ≥ 5 g/kg. EAD at the dose of 200 and 400 mg/kg, p. o. reduced the ulcer score in both physical and chemical-induced ulcer models. In PL model EAD (400 mg/kg, p. o.) and ursolic acid (50 mg/kg, p. o.) showed antisecretory property by inhibiting aggressive factors [increase in gastric pH (35.02%, 26.73%), whereas decreased gastric volume (43.55%, 34.35%) and acid-pepsin output (75.23%, 68.81%), respectively]. EAD at 400 mg/kg p. o. showed significant effect on proton pump inhibition while ursolic acid didn't showed any effect. Conclusion:The effects of EAD were accredited mainly to the offensive mechanism and justify its traditional usage in the treatment of gastric ulcers.

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“…It also decreased the level of myeloperoxidase. Topical application of gel also produced favorable effects on the level of pro-inflammatory cytokines (tumor necrosis factor-α, interleukin-1β, and interleukin -6), and VEGF (Joshi et al, 2016).…”

Section: Leea Macrophyllamentioning

confidence: 98%

“…Anti-oxidant activity of medicinal plants is due to the presence of various phytochemicals (Pawar et al, 2007). It has been reported that topical application of bioadhesive gel of ethanolic extract of L. macrophylla (5% w/v) increased the activity of catalase, superoxide dismutase, and glutathione and decreased MPO activity (Joshi et al, 2016).…”

Section: Wound Healing Mechanisms Of Medicinal Plantsmentioning

confidence: 99%

“…Recently many plant extracts have been reported for wound healing activity and their cellular mechanism of wound healing has been studied extensively. It has been demonstrated that many plant extracts processed wound healing via angiogenesis (Mirmalek et al, 2015;Shen et al, 2017), activation of NF-κB (Nicolaus et al, 2017), favoring proinflammatory cytokines (Joshi et al, 2016), upregulation of iNOS (Pereira et al, 2016) and alpha-1 type-1 collagen (Krishnappa et al, 2016), fibroblast proliferation (Seyed et al, 2016;Öz et al, 2016), and anti-oxidant activity (Joshi et al, 2016). Thus, the aim of this review was to collect information about the cellular mechanisms of wound healing plants recently reported by the investigators and present them in an organized or systematic way.…”

Section: Introductionmentioning

confidence: 99%

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Medicinal plants with wound healing potential

Firdous¹,

Sautya²

2018

Bangladesh J Pharmacol

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Systematic investigation of ethanolic extract from Leea macrophylla : Implications in wound healing

Cited by 32 publications

References 50 publications

Wound healing potential of Solanum xanthocarpum in streptozotocin-induced diabetic rats

Wound healing potential of Solanum xanthocarpum in streptozotocin-induced diabetic rats

Anti-Ulcer Study of Standardized Ethanol Root Extract of Aganosma Dichotoma and Isolated Ursolic Acid

Medicinal plants with wound healing potential

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