Systematic coordination chemistry and cytotoxicity of copper(II) complexes with methyl substituted 4-nitropyridine N-oxides

Advances in Copper Complexes as Anticancer Agents

“…Complexes without or with only one methyl group exhibited remarkable cytotoxic activity against SW7-07 and MCF-7 cells. Generally, for all cell lines, complexation increased cytotoxicity. , …”

“…These results prompted the same authors to consider the use of nitrate anion instead of chloride. Hence, nitrato copper­(II) complexes 18a – f of substituted pyridine- N -oxides ( L 18a – f ) were isolated as mononuclear, five-coordinated, trans isomers [Cu­(NO 3 ) 2 (H 2 O)­( L 18a – c ) 2 ] (Figure a) or four-coordinated [Cu­(NO 3 ) 2 ( L 18d ) 2 ], [Cu­(NO 3 ) 2 ( L 18e ) 2 ], and [Cu­(NO 3 ) 2 ( L 18f ) 2 ] (Figure b) species. , The organic ligands and copper complexes were tested in vitro for the cytotoxic activity against MCF-7, SW707, and murine P-388 cancer cells. All complexes were significantly cytotoxic toward P-388 cells.…”

“…123−125 A series of CuCl 2 complexes with methyl derivatives of 4nitropyridine-N-oxide was found to be moderately active cytostatics when studied in vitro. It was also found that the biological action of chloro complexes was affected by spatial and electronic properties of the organic coligand, 126 including the position of the methyl substituent(s). These results prompted the same authors to consider the use of nitrate ) 2 ] (Figure 16b) species.…”