2013
DOI: 10.1021/cr400135x
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Abstract: Copper is a transition metal that can exist in oxidized (Cu(II)) and reduced (Cu(I)) states. This allows it to participate in redox and catalytic chemistry, making it a suitable cofactor for a diverse range of enzymes and molecules. Copper complexes have been investigated for their therapeutic or diagnostic potential showing effectiveness in cancer treatment due to their cytotoxic action on tumour cells. In this review, the most remarkable achievements in the design and development of copper(I, II) complexes a… Show more

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Cited by 1,404 publications
(967 citation statements)
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References 423 publications
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“…Interestingly, Cu(II) alone also exerted a certain degree of cytotoxicity (with 69.2% of cell viability), which was lower than free DOX but higher than free AQ4N. This result was also consistent with previously reported studies regarding the anticancer properties of copper complexes 32. However, the ADMOPs had significantly higher cytotoxicity (with 21.9% of cell viability) than free DOX, free Cu(II), and free AQ4N due to the higher uptake of the nanosized form and the synergistic anticancer effects of DOX, Cu(II), and AQ4N.…”
Section: Resultssupporting
confidence: 92%
“…Interestingly, Cu(II) alone also exerted a certain degree of cytotoxicity (with 69.2% of cell viability), which was lower than free DOX but higher than free AQ4N. This result was also consistent with previously reported studies regarding the anticancer properties of copper complexes 32. However, the ADMOPs had significantly higher cytotoxicity (with 21.9% of cell viability) than free DOX, free Cu(II), and free AQ4N due to the higher uptake of the nanosized form and the synergistic anticancer effects of DOX, Cu(II), and AQ4N.…”
Section: Resultssupporting
confidence: 92%
“…As of today, very few copper complexes have been described that induce apoptosis through the involvement of the Caspase 3 (C3) [16][17]. The mechanism of C3 activation in copper-mediated cell death has not been fully elucidated [18]. It was found that copper-containing molecules and molecular complexes that trigger apoptosis have an impact on the levels of proteins involved in the apoptotic cascade, determining either an increase of pro-apoptotic or a decrease of anti-apoptotic molecules [18][19][20][21].…”
Section: Introductionmentioning
confidence: 99%
“…The mechanism of C3 activation in copper-mediated cell death has not been fully elucidated [18]. It was found that copper-containing molecules and molecular complexes that trigger apoptosis have an impact on the levels of proteins involved in the apoptotic cascade, determining either an increase of pro-apoptotic or a decrease of anti-apoptotic molecules [18][19][20][21]. In view of these contrasting data and considering the similarly contrasting views on whether Hsp60 has a pro-or anti-apoptotic role in tumor cells, we set out to do experiments aiming at clarifying the connections between Hsp60, pC3, C3, and apoptosis.…”
Section: Introductionmentioning
confidence: 99%
“…Its biological importance is also attributed to its ability to complex with medicinal compounds and affect its efficacy 3 . A wealth of literature is available documenting the potential benefits of Cu (II) for binding to biological organic molecules 4 and copper complexes being more effective than the drugs themselves 5 . There are numerous reports of Copper complexes of NSAIDS 6-10 , amino acids 11 , nucleobase 12, antibacterial agents 13 , anti-tubercular drugs 14 and anticancer drugs 15 .…”
Section: Introductionmentioning
confidence: 99%