Systematic biopsies accurately predict extracapsular extension of prostate cancer and persistent/recurrent detectable psa after radical prostatectomy

Ravery, Vincent; Dauge-Geffroy, M.-C.; Billebaud, T; Delmas, V.; Meulemans, A.; Toublanc, M.; Boccon‐Gibod, Liliane

doi:10.1016/s0090-4295(94)80095-2

Cited by 155 publications

(81 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…No study reported on all data items: the proportion of missing or incomplete items ranged from 18% 32 to 61% 24 with a median of 39%. The 21 studies came from 14 institutions (Tables 2 and 3), with only 5 institutions contributing to the radiotherapy literature.…”

Section: Resultsmentioning

confidence: 99%

“…Also excluded were articles reporting on the frequency of perineural invasion in patients with local recurrence 14 or on the outcomes of patients selected for small tumors and no perineural invasion, 15 as neither study had a control arm. The 10 surgical [16][17][18][19][20][21][22][23][24][25] and 11 radiotherapy [26][27][28][29][30][31][32][33][34][35][36] articles on perineural invasion in diagnostic biopsies form the basis of this report.…”

Section: Methodsmentioning

confidence: 99%

“…In 5 studies, 23,26,27,29,35 the slides were not reviewed but the diagnosis taken from the original report. In 3 articles, 22,24,31 this information was not provided.…”

Section: Test Methodsmentioning

confidence: 99%

“…20,21,23,27,29,35,36 No information was given in the remaining 5 articles. 18,22,24,26,31 No data were provided on intraobserver or interobserver variations in assessment of perineural invasion.…”

Section: Test Methodsmentioning

confidence: 99%

“…Individual patient data that allowed reanalysis could be extracted from 5 articles, 19,20,22,24,29 and data on specific subgroups of patients in a further 2 articles. 16,28 The proportion of patients with perineural invasion varied between 7 and 12% (median, 9%) when the diagnosis was taken from the original reports and between 7 and 42.5% (median, 23%) when slides were reviewed to identify perineural invasion.…”

Section: Outcome Evaluation (Tables 5 and 6)mentioning

confidence: 99%

See 4 more Smart Citations

The prognostic significance of perineural invasion in prostatic cancer biopsies

Harnden

Shelley

Clements

et al. 2006

Cancer

154

View full text Add to dashboard Cite

Men with clinically localized prostate cancer are faced with a wide range of treatment options, and only Gleason grading is universally used as a histopathological prognostic factor for this disease. The significance of perineural invasion in diagnostic biopsies is controversial. Opinion about whether or not it should influence treatment decisions is currently almost equally divided. To address this, the authors performed a systematic review of studies that examine the association between perineural invasion and prostate cancer recurrence. MEDLINE, Embase, and the Web of Knowledge were searched from January 1990 to December 2005.Outcomes analyzed were the development of biochemical or clinical recurrence. Twenty-one articles on the association of perineural invasion in biopsies and prostate cancer recurrence after radical prostatectomy (n ¼ 10) or radiotherapy (n ¼ 11) were found but none on its significance in the context of watchful waiting. Structured data extraction was performed to allow comparisons between articlesand to identify sources of heterogeneity to explain discrepancies in results. The considerable variation in study design, execution, and reporting precluded metaanalysis and quantitative risk estimation, but the weight of evidence suggested that perineural invasion in biopsies was a significant prognostic indicator, particularly in specific patient groups defined by presenting serum prostate-specific antigen levels and biopsy Gleason scores. Immediate treatment rather than watchful waiting may be more appropriate for patients with localized prostatic cancer and perineural invasion. However, the data are limited, and well-designed studies that use predefined stringent protocols are required to provide robust estimates of risk to aid in treatment planning.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…In 5 studies, 23,26,27,29,35 the slides were not reviewed but the diagnosis taken from the original report. In 3 articles, 22,24,31 this information was not provided.…”

Section: Test Methodsmentioning

confidence: 99%