The results of radical prostatectomy at a community hospital during the prostate specific antigen era

Smitt, Melanie C.; Heltzel, Marianne

doi:10.1002/(sici)1097-0142(19960301)77:5<928::aid-cncr19>3.0.co;2-5

Cited by 10 publications

(3 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is conceivable that the harm caused by over‐diagnosis and subsequent over‐treatment may overshadow the benefits of early detection [11,12]. Advocates of early detection have indicated that the survival after aggressive treatment of localized carcinomas is good [13,14], albeit that several observational studies show reasonable results with a watchful‐waiting policy [12,15,16].…”

Section: Introductionmentioning

confidence: 99%

Trends in the curative treatment of localized prostate cancer after the introduction of prostate‐specific antigen: data from the Rotterdam Cancer Registry

Spapen

Damhuis

Kirkels³

2000

BJU International

View full text Add to dashboard Cite

Objective To investigate changes in the incidence and treatment of prostate cancer over the period in which new diagnostic tools were introduced and the attitude towards treatment was changing. Patients and methods Information on the extent of disease and treatment of patients diagnosed with prostate cancer within the Rotterdam region was retrieved from the Rotterdam Cancer Registry. Results In the period 1989±95, 4344 patients were diagnosed with prostate cancer and the age-standardized incidence increased from 62 to 125 per 100 000 men. This increase mainly comprised tumours localized to the prostate, while the incidence of advanced cancers remained stable. The proportion of poorly differentiated tumours decreased from 33% in 1989 to 24% in 1995. In the same period the number of patients receiving radiotherapy increased from 80 to 258, while the annual number of radical prostatectomies rose from 17 to 159. Radiotherapy was the preferred type of treatment in patients over 70 years of age, whereas radical prostatectomy was used more frequently in younger patients with localized tumours. Conclusion While the value of screening for prostate cancer remains in debate, incidence and treatment patterns are changing rapidly. Information on patterns of care is needed to interpret future mortality data and to plan resources for adequate health care.

show abstract

Section: Introductionmentioning

confidence: 99%

Trends in the curative treatment of localized prostate cancer after the introduction of prostate‐specific antigen: data from the Rotterdam Cancer Registry

Spapen

Damhuis

Kirkels³

2000

BJU International

View full text Add to dashboard Cite

show abstract

“…The use of radical prostatectomy in the treatment of localized prostate cancer has increased with the advent of PSA screening (61,62). An elevation of serum PSA levels after radical prostatectomy is a sensitive indicator of persistent disease after surgery, and precedes clinical manifestations of disease progression (63,64).…”

Section: Psa After Radical Prostatectomymentioning

confidence: 99%

Prostate-Specific Antigen and New Related Markers for Prostate Cancer

Daher¹,

Beaini²

1998

CCLM

View full text Add to dashboard Cite

Although prostate-specific antigen (PSA), or human kallikrein 3, is the most valuable tool available for the diagnosis and management of prostate cancer, as currently used it is insufficiently sensitive and specific for early detection or staging of the malignancy. Many new concepts have been introduced in order to optimize the clinical use of PSA measurements, but each one has its own drawbacks. The molecular forms of PSA, especially the free PSA, seem to be useful for the detection of prostate cancer in men with PSA concentrations falling in the 4-10 microg/l range. New molecular techniques, such as reverse transcriptase polymerase chain reaction for the detection of minimal amounts of PSA messenger RNA and prostate-specific membrane antigen, offer new promise for the prognosis and possibly staging of prostate cancer. On the other hand, human kallikrein 2, a serine protease closely related to PSA that is also expressed predominantly in the prostate, may be a new adjuvant marker for prostate cancer. As for its biological functions, PSA can no longer be regarded as a specific prostate molecule associated mainly with semen liquefaction when it has a possible role as a prognostic indicator in female breast cancer. The biological role of PSA in normal tissues and tumors may be much more complex than previously thought and requires further investigation.

show abstract

“…17 Preoperative PSA levels contribute prognostic information, because higher levels of PSA imply greater tumor volume and greater chance of tumor recurrence after surgery. [17][18][19][20][21][22][23][24][25][26][27] Finally, many have reported that the level and dynamics of postoperative PSA relate to subsequent outcome. 1,6,13,18,[28][29][30][31][32][33] The PSA level clearly rises before other signs of recurrent tumor, 6,19 and several have reported that dynamic measures such as the time to first elevation of the PSA level, PSA velocity, PSA doubling time, and PSA level at 1 year relate significantly to adverse outcome.…”

Section: Introductionmentioning

confidence: 99%

The Relative Importance of Anatomic and PSA Factors to Outcomes After Radical Prostatectomy for Prostate Cancer

Vollmer

Humphrey

2001

Am J Clin Pathol

View full text Add to dashboard Cite

We report on how anatomic pathology observations and prostate-specific antigen (PSA) observations made before and just after radical prostatectomy relate to subsequent outcomes in men with prostate cancer. Our study patients consisted of more than 200 men who underwent radical prostatectomy and who had a mean follow-up of more than 6 years. We found that there were 2 categories of failures after surgery--one consisting of an eventual elevated PSA level and the other consisting of an early death from progressive tumor--and that these 2 failures related differently to PSA and anatomic pathology observations made at the time of prostatectomy. Whereas preoperative and postoperative levels of PSA related most closely to PSA failure, Gleason grade 5 and the percentage carcinoma related most closely to early death. Our results suggest how men could be sorted into 3 prognostic categories after surgery: one with high hazard for early death, a second with low hazard for early death but with high probability for eventual elevated PSA level, and a third with overall good prognosis.

show abstract

The results of radical prostatectomy at a community hospital during the prostate specific antigen era

Cited by 10 publications

References 24 publications

Trends in the curative treatment of localized prostate cancer after the introduction of prostate‐specific antigen: data from the Rotterdam Cancer Registry

Trends in the curative treatment of localized prostate cancer after the introduction of prostate‐specific antigen: data from the Rotterdam Cancer Registry

Prostate-Specific Antigen and New Related Markers for Prostate Cancer

The Relative Importance of Anatomic and PSA Factors to Outcomes After Radical Prostatectomy for Prostate Cancer

Contact Info

Product

Resources

About